INT124670

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Context Info
Confidence 0.77
First Reported 2005
Last Reported 2010
Negated 5
Speculated 1
Reported most in Body
Documents 53
Total Number 55
Disease Relevance 4.83
Pain Relevance 19.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Grik1) plasma membrane (Grik1)
Anatomy Link Frequency
neurons 12
nociceptors 5
dorsal horn 4
spinal cord 3
spinal 3
Grik1 (Mus musculus)
Pain Link Frequency Relevance Heat
nociceptor 644 100.00 Very High Very High Very High
Glutamate receptor 68 100.00 Very High Very High Very High
substantia gelatinosa 1090 99.98 Very High Very High Very High
Inflammation 49 99.90 Very High Very High Very High
GABAergic 332 99.84 Very High Very High Very High
gABA 403 99.74 Very High Very High Very High
amygdala 620 99.68 Very High Very High Very High
Dorsal horn 236 99.68 Very High Very High Very High
Root ganglion neuron 5 99.56 Very High Very High Very High
Pyramidal cell 125 99.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 74 99.90 Very High Very High Very High
Ganglion Cysts 59 99.36 Very High Very High Very High
Nociception 350 99.30 Very High Very High Very High
Inflammatory Pain 59 99.28 Very High Very High Very High
Anxiety Disorder 275 97.04 Very High Very High Very High
Pain 240 95.40 Very High Very High Very High
Targeted Disruption 162 83.60 Quite High
Cancer 2 63.76 Quite High
Panic Disorder 5 63.72 Quite High
Epilepsy 19 43.52 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of GluR5 in the dorsal horn is still a matter of debate.
Gene_expression (expression) of GluR5 in dorsal horn associated with dorsal horn
1) Confidence 0.77 Published 2006 Journal Mol Pain Section Body Doc Link PMC1570342 Disease Relevance 0 Pain Relevance 0.40
Accordingly, intrathecal injection of a selective GluR5 antagonist reduced nociceptive responses to CFA inflammation and GluR5 expression was increased in the spinal cords of CFA treated animals [50].
Gene_expression (expression) of GluR5 in spinal cords associated with nociception, inflammation, antagonist and intrathecal
2) Confidence 0.77 Published 2006 Journal Mol Pain Section Body Doc Link PMC1570342 Disease Relevance 0.72 Pain Relevance 0.73
While one study reported a large number of primary afferents expressing GluR5-7 in the dorsal horn [42], another study showed low levels of GluR5 expression [43].
Gene_expression (expressing) of GluR5 in dorsal horn associated with dorsal horn
3) Confidence 0.77 Published 2006 Journal Mol Pain Section Body Doc Link PMC1570342 Disease Relevance 0 Pain Relevance 0.40
While one study reported a large number of primary afferents expressing GluR5-7 in the dorsal horn [42], another study showed low levels of GluR5 expression [43].
Gene_expression (expression) of GluR5 in dorsal horn associated with dorsal horn
4) Confidence 0.77 Published 2006 Journal Mol Pain Section Body Doc Link PMC1570342 Disease Relevance 0 Pain Relevance 0.40
These results show that the GluR5 KAR subunits are expressed functionally on the SG neurons of the Vc in mice, and the expression levels of the GluR5 subunits decrease with postnatal development.
Gene_expression (expression) of GluR5 in neurons associated with substantia gelatinosa
5) Confidence 0.75 Published 2010 Journal Brain Res. Section Abstract Doc Link 20513362 Disease Relevance 0.06 Pain Relevance 0.48
Previous reports show that GluR5 is expressed in the BLA where it participates in synaptic transmission, modulation and plasticity in young rats [22], [25].
Gene_expression (expressed) of GluR5 associated with amygdala
6) Confidence 0.71 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1766473 Disease Relevance 0.41 Pain Relevance 0.45
KA receptors are widely distributed in the peripheral and central nervous systems and, in particular, the GluR5 subunit is highly expressed in dorsal root ganglion neurons, piriform and cingulate cortices, hippocampal interneurons, as well as in the BLA [22]–[24].
Gene_expression (expressed) of GluR5 in neurons associated with ganglion cysts, root ganglion neuron and amygdala
7) Confidence 0.71 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1766473 Disease Relevance 0.57 Pain Relevance 0.50
In previous studies, using in situ hybridization, the expression of Grik1/GluR5 was detected in mouse DRG from E12 onward, using a rat probe on mouse tissue [30], and by RT-PCR in E16 rat DRG tissue [29].
Gene_expression (expression) of GluR5
8) Confidence 0.68 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2241628 Disease Relevance 0.08 Pain Relevance 0.21
Thus Grik1/GluR5 expression seems to coincide with the appearance of the population of nociceptors that down-regulate TrkA and express c-Ret and bind isolectin B4 [8].
Gene_expression (expression) of Grik1 in nociceptors associated with nociceptor
9) Confidence 0.68 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2241628 Disease Relevance 0 Pain Relevance 0.29
However, Grik1/GluR5 was expressed in a sub-population (73 % +/- 0.8) of neurons of small cell body diameter labelled by c-Ret (Figure 4L).
Gene_expression (expressed) of Grik1 in neurons
10) Confidence 0.68 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2241628 Disease Relevance 0 Pain Relevance 0.23
Grik1/GluR5 expression was absent from each of the TrkA, TrkB and TrkC expressing populations (Figure 4C, F, I).
Neg (absent) Gene_expression (expression) of GluR5
11) Confidence 0.68 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2241628 Disease Relevance 0 Pain Relevance 0.23
In previous studies, using in situ hybridization, the expression of Grik1/GluR5 was detected in mouse DRG from E12 onward, using a rat probe on mouse tissue [30], and by RT-PCR in E16 rat DRG tissue [29].
Gene_expression (expression) of Grik1
12) Confidence 0.68 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2241628 Disease Relevance 0.08 Pain Relevance 0.21
Virtually all Grik1/GluR5-expressing neurons were IB4-positive.
Gene_expression (expressing) of GluR5 in neurons
13) Confidence 0.68 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2241628 Disease Relevance 0 Pain Relevance 0.21
A body of evidence shows that Grik1/Glur5 receptors are expressed in sensory neurons of the DRG and are transported to the spinal cord where they are an essential component of presynaptic kainate receptors thought to play a role in the modulation of pain sensation [28].
Gene_expression (expressed) of Grik1 in body associated with pain and spinal cord
14) Confidence 0.68 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2241628 Disease Relevance 0.09 Pain Relevance 0.17
Grik1/GluR5 expression persisted in a sub-population of cells (37% +/- 1.3 of all neurons) in the adult (Figure 3R).


Gene_expression (expression) of Grik1 in neurons
15) Confidence 0.68 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2241628 Disease Relevance 0.05 Pain Relevance 0.18
Thus Grik1/GluR5 expression seems to coincide with the appearance of the population of nociceptors that down-regulate TrkA and express c-Ret and bind isolectin B4 [8].
Gene_expression (expression) of GluR5 in nociceptors associated with nociceptor
16) Confidence 0.68 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2241628 Disease Relevance 0 Pain Relevance 0.29
Nevertheless, our in situ hybridization and QRT-PCR results suggest that high Grik1/GluR5 expression appears at the late embryonic phase.
Gene_expression (expression) of Grik1
17) Confidence 0.68 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2241628 Disease Relevance 0.05 Pain Relevance 0.25
However, Grik1/GluR5 was expressed in a sub-population (73 % +/- 0.8) of neurons of small cell body diameter labelled by c-Ret (Figure 4L).
Gene_expression (expressed) of GluR5 in neurons
18) Confidence 0.68 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2241628 Disease Relevance 0 Pain Relevance 0.23
The kainate receptor Grik1/GluR5 was expressed in a sub-population of cells of neuronal morphology in wild-type DRG and was completely absent in TrkA mutant DRG, strongly suggesting nociceptor specific expression (Figure 3P, Q, R).
Neg (absent) Gene_expression (expressed) of GluR5 in nociceptor associated with nociceptor
19) Confidence 0.68 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2241628 Disease Relevance 0.12 Pain Relevance 0.24
The kainate receptor Grik1/GluR5 was expressed in a sub-population of cells of neuronal morphology in wild-type DRG and was completely absent in TrkA mutant DRG, strongly suggesting nociceptor specific expression (Figure 3P, Q, R).
Neg (absent) Gene_expression (expressed) of Grik1 in nociceptor associated with nociceptor
20) Confidence 0.68 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2241628 Disease Relevance 0.12 Pain Relevance 0.24

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