INT124702

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Context Info
Confidence 0.69
First Reported 2005
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 21
Total Number 44
Disease Relevance 7.14
Pain Relevance 8.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Trpv4) cilium (Trpv4) transmembrane transport (Trpv4)
Anatomy Link Frequency
growth cone 4
neurite 3
sensory nerves 2
neurons 1
dorsal root ganglion 1
Trpv4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Taxol 660 99.98 Very High Very High Very High
agonist 158 99.98 Very High Very High Very High
nociceptor 30 99.88 Very High Very High Very High
qutenza 85 99.84 Very High Very High Very High
TRP channel 56 99.66 Very High Very High Very High
Pain 314 99.56 Very High Very High Very High
imagery 274 99.40 Very High Very High Very High
peripheral neuropathy 22 99.24 Very High Very High Very High
dorsal root ganglion 360 99.04 Very High Very High Very High
Kinase C 24 98.70 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pressure Volume 2 Under Development 8 99.76 Very High Very High Very High
Stress 35 99.50 Very High Very High Very High
Peripheral Neuropathy 22 99.24 Very High Very High Very High
Ganglion Cysts 384 98.56 Very High Very High Very High
INFLAMMATION 50 98.36 Very High Very High Very High
Pressure And Volume Under Development 2 97.92 Very High Very High Very High
Nociception 341 97.44 Very High Very High Very High
Pain 286 95.64 Very High Very High Very High
Inflammatory Pain 37 90.00 High High
Myelodysplastic Syndromes 1 89.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Specimens of the experimental IDLE demonstrated a significant increase of TRPV4 activity in particular in stratum basale of conical papillae (p < 0.01). pERK-IR positive neurons were significantly increased in the RMg (p < 0.05), Sp5C (p < 0.05) and Md (p < 0.01); TRPV4-IR neurons were found to show a similar distribution with pERK-IR cells in the peripheral Sp5C (p < 0.05).
Positive_regulation (increase) of TRPV4 in neurons
1) Confidence 0.69 Published 2009 Journal Okajimas Folia Anat Jpn Section Abstract Doc Link 19877445 Disease Relevance 0.44 Pain Relevance 0.40
The mechanism of activation of the transient receptor potential vanilloid 4 (TRPV4) channel by 4alpha-phorbol esters was investigated by combining information from chemical modification of 4alpha-phorbol-didecanoate (4alpha-PDD, 2a), site-directed mutagenesis, Ca(2+) imaging, and electrophysiology.
Positive_regulation (activation) of TRPV4 associated with imagery
2) Confidence 0.69 Published 2009 Journal J. Med. Chem. Section Abstract Doc Link 19361196 Disease Relevance 0 Pain Relevance 0.12
All these results confirm that activation of TRPV4 results in microtubules disassembly and this effect is independent of TRPV4 expression level in whatever cellular context chosen.


Positive_regulation (activation) of TRPV4
3) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2906515 Disease Relevance 0 Pain Relevance 0
As activation of TRPV4 results in high Ca2+-influx, we tested if higher concentration of Ca2+ could modulate these interactions.
Positive_regulation (activation) of TRPV4
4) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2906515 Disease Relevance 0.47 Pain Relevance 0.25
Stabilization of microtubules by Taxol reduces Ca2+-influx through TRPV4 activation
Positive_regulation (activation) of TRPV4 associated with taxol
5) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2906515 Disease Relevance 0 Pain Relevance 0.12
Activation of TRPV4 results in fast retraction of growth cones in F11 cell
Positive_regulation (Activation) of TRPV4 in growth cones
6) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2906515 Disease Relevance 0.18 Pain Relevance 0.07
So we tested if TRPV4 activation can alter the morphology and movement of growth cones.
Positive_regulation (activation) of TRPV4 in growth cones
7) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2906515 Disease Relevance 0.18 Pain Relevance 0.08
In agreement with this concept, it is important to note that activation of single TRPV4 ion channel in response to heat is possible in whole cell recordings but not in a cell-free inside-out patch clamp experiments, suggesting that in the latter some cellular factor is missing [83].
Positive_regulation (activation) of TRPV4
8) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2906515 Disease Relevance 0.12 Pain Relevance 0.19
We observed that activation of TRPV4 by 4?
Positive_regulation (activation) of TRPV4
9) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2906515 Disease Relevance 0 Pain Relevance 0.03
In experiments aiming to activated TRPV4, its agonist 4 ?
Positive_regulation (activated) of TRPV4 associated with agonist
10) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2906515 Disease Relevance 0 Pain Relevance 0.18
The mechanism of activation of the transient receptor potential vanilloid 4 (TRPV4) channel by 4alpha-phorbol esters was investigated by combining information from chemical modification of 4alpha-phorbol-didecanoate (4alpha-PDD, 2a), site-directed mutagenesis, Ca(2+) imaging, and electrophysiology.
Positive_regulation (activation) of transient receptor potential vanilloid 4 associated with imagery
11) Confidence 0.60 Published 2009 Journal J. Med. Chem. Section Abstract Doc Link 19361196 Disease Relevance 0 Pain Relevance 0.12
TRPV1 and TRPV4, two calcium-permeable channels of the vanilloid subfamily of TRP proteins, are activated by various physical and chemical stimuli, including noxious heat and mechanical stress, respectively.
Positive_regulation (activated) of TRPV4 associated with stress
12) Confidence 0.56 Published 2010 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 20043876 Disease Relevance 0.32 Pain Relevance 0.42
Exercise-induced Trpv4 up-regulation, not significantly different from that achieved with shunt, returned to control values when evaluated 6h post exercise.
Positive_regulation (induced) of Trpv4
13) Confidence 0.50 Published 2010 Journal Eur J Vasc Endovasc Surg Section Body Doc Link 20304685 Disease Relevance 0 Pain Relevance 0
Cell culture and in vivo studies demonstrate that an FSS- or a 4alphaPDD-induced activation of Trpv4 leads to an active proliferation of vascular cells and finally triggers collateral growth.
Positive_regulation (activation) of Trpv4 associated with stress
14) Confidence 0.50 Published 2009 Journal J. Cell. Mol. Med. Section Abstract Doc Link 19017361 Disease Relevance 0.38 Pain Relevance 0
To detect the roles of various vasodilating factors released by vascular endothelium in the hypotensive effect induced by TRPV4 activation, the corresponding inhibitors/blockers, including indomethacin (a cyclooxygenase inhibitor, 10 mg/kg, i.v.), Nomega-nitro-L-arginine (L-NA, a nitric oxide synthase inhibitor, 20 mg/kg, i.v.), apamin [a blocker of small conductance Ca2+-activated K+ (MaxiK) channels, 50 microg/kg, i.v.] combined with charybdotoxin (a blocker of intermediate and large conductance MaxiK channels, 50 microg/kg, i.v.), were used at various time before 4alpha-PDD injection.
Positive_regulation (activation) of TRPV4 in vascular endothelium
15) Confidence 0.49 Published 2010 Journal J. Hypertens. Section Body Doc Link 19996988 Disease Relevance 0.06 Pain Relevance 0
CONCLUSION: Our data show that the hypotensive effect induced by TRPV4 activation attributes to, at least in part, activation of MaxiK channels and CGRP receptors upon CGRP release from sensory nerves.


Positive_regulation (activation) of TRPV4 in sensory nerves
16) Confidence 0.49 Published 2010 Journal J. Hypertens. Section Body Doc Link 19996988 Disease Relevance 0 Pain Relevance 0
OBJECTIVE: To examine the mechanisms involved in hypotension induced by transient receptor potential vanilloid 4 (TRPV4) activation.
Spec (examine) Positive_regulation (induced) of TRPV4 associated with pressure volume 2 under development
17) Confidence 0.49 Published 2010 Journal J. Hypertens. Section Abstract Doc Link 19996988 Disease Relevance 0.17 Pain Relevance 0
We observed that the normalized average Ca2+-influx due to TRPV4 activation was strongly diminished (but not abolished) if the cells were treated with Taxol (Fig. 6a).
Positive_regulation (activation) of TRPV4 associated with taxol
18) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2906515 Disease Relevance 0 Pain Relevance 0.24
Thus we tested if long-term exposure to a TRPV4 agonist but a low-level activation of TRPV4 can regulate the neurites.
Positive_regulation (activation) of TRPV4 in neurites associated with agonist
19) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2906515 Disease Relevance 0.52 Pain Relevance 0.39
The interplay of TRPV4 with microtubule cytoskeleton also appears on a behavioural level, where alteration of microtubule dynamics by Taxol induces a TRPV4-dependent painful peripheral neuropathy [30].
Positive_regulation (induces) of TRPV4 associated with pain, peripheral neuropathy and taxol
20) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2906515 Disease Relevance 0.46 Pain Relevance 0.45

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