INT124705

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Context Info
Confidence 0.47
First Reported 2004
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 29
Total Number 32
Disease Relevance 19.02
Pain Relevance 5.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il18) extracellular region (Il18) cytoplasm (Il18)
Anatomy Link Frequency
macrophages 2
brain 2
spinal cord 1
salivary glands 1
heart 1
Il18 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 710 100.00 Very High Very High Very High
rheumatoid arthritis 138 99.84 Very High Very High Very High
anesthesia 12 99.76 Very High Very High Very High
Spinal cord 105 99.68 Very High Very High Very High
Inflammatory response 48 99.20 Very High Very High Very High
Inflammation 495 98.08 Very High Very High Very High
Brush evoked pain 15 97.40 Very High Very High Very High
intrathecal 23 97.08 Very High Very High Very High
Central nervous system 356 95.28 Very High Very High Very High
ischemia 59 95.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Syndrome 7 100.00 Very High Very High Very High
Salivary Gland Disease 2 100.00 Very High Very High Very High
Rheumatoid Arthritis 138 99.84 Very High Very High Very High
Obesity 45 99.56 Very High Very High Very High
Nervous System Injury 45 99.54 Very High Very High Very High
Disease 566 99.30 Very High Very High Very High
INFLAMMATION 558 99.20 Very High Very High Very High
Stroke 67 99.04 Very High Very High Very High
Systemic Inflammatory Response Syndrome 1 98.72 Very High Very High Very High
Asthma 416 98.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the extra cellular domain IL-18 is antagonised by IL-18 binding protein and in part by soluble IL-18R?
IL-18 Binding (binding) of
1) Confidence 0.47 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064903 Disease Relevance 0.51 Pain Relevance 0.25
The foregoing discussion clearly indicates that IL-18 offers potential as a therapeutic target in RA.
IL-18 Binding (target) of associated with rheumatoid arthritis
2) Confidence 0.47 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064903 Disease Relevance 0.98 Pain Relevance 0.48
Thus, it is perhaps not surprising that IL-18 was found to be associated with or demonstrated to contribute to numerous inflammatory-associated disorders.
IL-18 Binding (associated) of associated with inflammation
3) Confidence 0.46 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2830964 Disease Relevance 0.78 Pain Relevance 0.25
Of these, IL-1F7b (also known as IL-1H, IL-1H4 and IL-1RP1) matured by caspase-1 is capable of binding IL-18R?
IL-18R Binding (binding) of
4) Confidence 0.46 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2830964 Disease Relevance 0.14 Pain Relevance 0.03
, IL-18 seems to be associated with the mid-stage inflammatory response to ischemic brain lesions.
IL-18 Binding (associated) of in brain associated with inflammatory response
5) Confidence 0.37 Published 2010 Journal Exp Transl Stroke Med Section Body Doc Link PMC2820471 Disease Relevance 0.80 Pain Relevance 0.12
IL-18 is a proinflammatory cytokine of the IL-1 family, recognized for its ability to promote IFN-gamma secretion.
IL-18 Binding (recognized) of associated with cytokine
6) Confidence 0.36 Published 2005 Journal Int. J. Cardiol. Section Abstract Doc Link 15676165 Disease Relevance 0.86 Pain Relevance 0.58
High affinity binding by IL-18 binding protein a and c isoforms renders these obvious neutralising agents, and early clinical studies to establish the safety of this approach are in progress.
IL-18 Binding (affinity) of
7) Confidence 0.36 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064903 Disease Relevance 0.12 Pain Relevance 0.12
High affinity binding by IL-18 binding protein a and c isoforms renders these obvious neutralising agents, and early clinical studies to establish the safety of this approach are in progress.
IL-18 Binding (binding) of
8) Confidence 0.36 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064903 Disease Relevance 0.12 Pain Relevance 0.12
However, two recent nested case-control studies have not confirmed an association of IL-18 with increased risk of stroke in older people [21] or with recurrent stroke [22].
IL-18 Neg (not) Binding (association) of associated with stroke
9) Confidence 0.36 Published 2010 Journal Exp Transl Stroke Med Section Body Doc Link PMC2820471 Disease Relevance 0.51 Pain Relevance 0
Elevated IL-18 has been associated with neurological dysfunction, systemic inflammatory response syndrome (SIRS), and multiple organ dysfunction syndrome (MODS) post open-heart surgery.
IL-18 Binding (associated) of in heart associated with multiple organ failure, inflammatory response, anesthesia and systemic inflammatory response syndrome
10) Confidence 0.36 Published 2008 Journal Perfusion Section Abstract Doc Link 19181757 Disease Relevance 0.29 Pain Relevance 0.20
Initially IL-18 was investigated for its similarities with IL-1?
IL-18 Binding (investigated) of
11) Confidence 0.36 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2830964 Disease Relevance 0.69 Pain Relevance 0.15
Isolated as cytokine-binding molecules, this 38-kDa soluble protein displays some sequence homology with IL-18R?
IL-18R Binding (homology) of associated with cytokine
12) Confidence 0.36 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2830964 Disease Relevance 0 Pain Relevance 0.08
The first being the recognition that Il-18 and Il-1?
Il-18 Binding (recognition) of
13) Confidence 0.36 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2830964 Disease Relevance 0.67 Pain Relevance 0.19
IL-18BP binds selectively and with high affinity to mature IL-18, but not to pro-IL-18, preventing its interaction with IL-18R?.
IL-18 Binding (interaction) of
14) Confidence 0.36 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2830964 Disease Relevance 0 Pain Relevance 0.08
Indeed, in another Italian population a lack of association between IL-18 gene promoter polymorphisms and onset of AD was reported, indicating that the association of IL-18 promoter polymorphisms with AD is not so strong, AD being a multifactorial disease [115].
IL-18 Binding (association) of associated with disease
15) Confidence 0.36 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2830964 Disease Relevance 1.62 Pain Relevance 0.08
The lethargic effects of IL-18 were also observed following intraperitoneal injection of IL-18, whereas, unlike IL-1?
IL-18 Binding (injection) of
16) Confidence 0.36 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2830964 Disease Relevance 0.75 Pain Relevance 0.22
IL-18BP binds selectively and with high affinity to mature IL-18, but not to pro-IL-18, preventing its interaction with IL-18R?.
IL-18R Binding (interaction) of
17) Confidence 0.36 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2830964 Disease Relevance 0 Pain Relevance 0.08
IL-1F7 is able to bind IL-18BP and the IL-18BP/IL-1F7 complex can interact with the IL-18R?
IL-18R Binding (interact) of
18) Confidence 0.36 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2830964 Disease Relevance 0 Pain Relevance 0.04
Indeed, in another Italian population a lack of association between IL-18 gene promoter polymorphisms and onset of AD was reported, indicating that the association of IL-18 promoter polymorphisms with AD is not so strong, AD being a multifactorial disease [115].
IL-18 Binding (association) of associated with disease
19) Confidence 0.34 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2830964 Disease Relevance 1.69 Pain Relevance 0.13
chain preventing the formation of the funtional IL-18R complex [34].
IL-18R Binding (formation) of
20) Confidence 0.34 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2830964 Disease Relevance 0.10 Pain Relevance 0.04

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