INT12471

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Context Info
Confidence 0.35
First Reported 1987
Last Reported 2010
Negated 8
Speculated 8
Reported most in Abstract
Documents 52
Total Number 60
Disease Relevance 17.80
Pain Relevance 48.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

kinase activity (Insrr)
Anatomy Link Frequency
brain 6
embryonic kidney 2
cartilage 1
vas deferens 1
spinal 1
Insrr (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 207 100.00 Very High Very High Very High
Morphine 189 100.00 Very High Very High Very High
opioid receptor 155 100.00 Very High Very High Very High
Pain 125 100.00 Very High Very High Very High
antagonist 94 100.00 Very High Very High Very High
Opioid 75 100.00 Very High Very High Very High
nMDA receptor 45 100.00 Very High Very High Very High
Eae 34 100.00 Very High Very High Very High
gABA 32 100.00 Very High Very High Very High
Kappa opioid receptor 30 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 125 100.00 Very High Very High Very High
Pancreatic Cancer 42 99.84 Very High Very High Very High
Neuropathic Pain 123 99.80 Very High Very High Very High
Sprains And Strains 26 99.44 Very High Very High Very High
Hyperalgesia 126 99.32 Very High Very High Very High
Injury 47 99.20 Very High Very High Very High
Drug Dependence 9 99.20 Very High Very High Very High
Ganglion Cysts 24 99.16 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 7 99.08 Very High Very High Very High
Inflammatory Pain 44 99.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We investigated the effects of 1-amino-5-bromouracil on the benzodiazepine-gamma-aminobutyric acid (GABA)A receptor complex to elucidate its central action. 1-Amino-5-bromouracil neither displaced nor enhanced [3H]muscimol, [35S]t-butylbicyclophosphorothionate (TBPS), or [3H]dehydroepiandrosterone sulfate binding to the rat brain synaptosomal membranes.
Spec (investigated) Regulation (effects) of receptor in brain associated with gaba
1) Confidence 0.35 Published 1994 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7698200 Disease Relevance 0.18 Pain Relevance 0.13
In the present study, we investigated the effect of ET(A) receptor antagonists, BQ123 and BMS182874, on morphine antinociception and tolerance in mice.
Spec (investigated) Regulation (effect) of ) receptor associated with antinociception, antagonist, tolerance and morphine
2) Confidence 0.34 Published 2005 Journal Brain Res. Section Abstract Doc Link 16289404 Disease Relevance 0 Pain Relevance 1.42
Dopamine receptor antagonists or agonists alone or in combination with melatonin did not affect locomotor activity.
Neg (not) Regulation (affect) of receptor associated with eae, antagonist, dopamine receptor and agonist
3) Confidence 0.23 Published 2010 Journal Eur. J. Pharmacol. Section Abstract Doc Link 20406627 Disease Relevance 0.07 Pain Relevance 1.11
The present study was designed to study the effects of NMDA and group I mGlu receptor agents on delta- and mu-opioid receptor agonist-induced antinociception in the mouse brain.
Regulation (effects) of receptor in brain associated with antinociception, agonist and opioid receptor
4) Confidence 0.20 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10822049 Disease Relevance 0.10 Pain Relevance 0.94
The present study evaluated the effects of different histamine receptor agonists and antagonists on the nociceptive response in the mouse formalin test.
Regulation (effects) of receptor associated with nociception, antagonist and agonist
5) Confidence 0.20 Published 2007 Journal Eur Neuropsychopharmacol Section Abstract Doc Link 16631358 Disease Relevance 0.31 Pain Relevance 0.50
RATIONALE: Neuroactive steroids represent a novel class of potential therapeutic agents (epilepsy, anxiety, migraine, drug dependence) thought to act through positive allosteric modulation of the GABA(A) receptor.
Regulation (modulation) of ) receptor associated with drug dependence, epilepsy, addiction, gaba, migraine and anxiety disorder
6) Confidence 0.18 Published 2000 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 10928304 Disease Relevance 0.56 Pain Relevance 0.24
Multiple muscarinic acetylcholine receptor subtypes modulate striatal dopamine release, as studied with M1-M5 muscarinic receptor knock-out mice.
Regulation (modulate) of receptor associated with targeted disruption and dopamine
7) Confidence 0.15 Published 2002 Journal J. Neurosci. Section Title Doc Link 12151512 Disease Relevance 0.18 Pain Relevance 0.28
The histamine receptor agonist and antagonists, at the doses used in the present study, did not affect the response of unrestrained animals to the hot plate test.
Neg (not) Regulation (affect) of receptor associated with antagonist and agonist
8) Confidence 0.13 Published 1995 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7556390 Disease Relevance 0 Pain Relevance 0.75
Both toluene and TCE decreased benzodiazepine receptor binding levels in discrete brain areas, but had no effect on NMDA receptor levels.
Neg (no) Regulation (effect) of receptor in brain associated with nmda receptor
9) Confidence 0.12 Published 2008 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 18991886 Disease Relevance 0.26 Pain Relevance 1.38
These results suggest that the hyperactivity, reverse tolerance and postsynaptic dopamine receptor supersensitivity induced by morphine may be modulated via the activation of the GABA(A) receptor induced by diazepam.
Regulation (modulated) of receptor associated with gaba, dopamine receptor, tolerance, attention deficit hyperactivity disorder and morphine
10) Confidence 0.11 Published 2001 Journal Pharmacol. Res. Section Abstract Doc Link 11735352 Disease Relevance 0.50 Pain Relevance 1.39
Importance of CCK-A receptor for gallbladder contraction and pancreatic secretion: a study in CCK-A receptor knockout mice.
Regulation (Importance) of receptor associated with targeted disruption
11) Confidence 0.09 Published 2001 Journal Jpn. J. Physiol. Section Title Doc Link 11734079 Disease Relevance 0.10 Pain Relevance 0.32
Moreover, while the antidepressant-like effect of zinc (5 mg/kg) in the FST was significantly blocked by pretreatment with inhibitor of serotonin synthesis, p-chlorophenylalanine (pCPA, 3x200 mg/kg), 5HT-2(A/C) receptor antagonist, ritanserin (4 mg/kg) or 5HT-1A receptor antagonist, WAY 1006335 (0.1 mg/kg), the zinc-induced reduction in the locomotor activity was not affected by these serotonin modulator agents.
Neg (not) Regulation (affected) of receptor associated with antidepressant, antagonist, eae, 5ht and serotonin
12) Confidence 0.08 Published 2009 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Abstract Doc Link 19150479 Disease Relevance 0.07 Pain Relevance 1.03
Tiagabine antinociception in rodents depends on GABA(B) receptor activation: parallel antinociception testing and medial thalamus GABA microdialysis.
Regulation (depends) of receptor in thalamus associated with antinociception, gaba, narcan and thalamus
13) Confidence 0.06 Published 1999 Journal Eur. J. Pharmacol. Section Title Doc Link 10193656 Disease Relevance 0.15 Pain Relevance 1.03
We studied the effects of peripherally administered (s.c.) mu, delta and kappa opioid receptor selective agonists on the rate of gastrointestinal transit in mice.
Regulation (effects) of receptor associated with agonist and kappa opioid receptor
14) Confidence 0.06 Published 1987 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2824748 Disease Relevance 0.19 Pain Relevance 0.76
A novel signaling pathway of nitric oxide on transcriptional regulation of mouse kappa opioid receptor gene.
Regulation (regulation) of receptor associated with kappa opioid receptor
15) Confidence 0.04 Published 2002 Journal J. Neurosci. Section Title Doc Link 12223547 Disease Relevance 0.09 Pain Relevance 0.29
Chronic in vivo treatment with opioid antagonists increases opioid receptor density and the potency of opioid agonists without altering receptor mRNA levels.
Neg (without) Regulation (altering) of receptor associated with mu agonist, antagonist, opioid receptor, opioid and potency
16) Confidence 0.04 Published 1999 Journal Life Sci. Section Abstract Doc Link 10416817 Disease Relevance 0.08 Pain Relevance 0.71
Using mouse L(-tk) cells, we stably expressed the native GABA(A) receptor subunit combinations alpha(3)beta(3)gamma(2,) alpha(4)beta(3)gamma(2), and, for the first time, alpha(4)beta(3)delta and characterized their properties using a novel fluorescence resonance energy transfer assay of GABA-evoked depolarizations.
Regulation (native) of ) receptor associated with gaba
17) Confidence 0.04 Published 2001 Journal J. Biol. Chem. Section Abstract Doc Link 11495904 Disease Relevance 0.19 Pain Relevance 0.39
The present study was designed to investigate the possible change in spinal micro -opioid receptor function after repeated administration of a selective kappa-opioid receptor agonist (1S-trans)-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl) cyclohexyl]-benzeneacetamide hydrochloride [(-)U-50,488H] in the ICR mouse.
Spec (possible) Regulation (change) of receptor in spinal associated with agonist, kappa opioid receptor and opioid receptor
18) Confidence 0.03 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 14622150 Disease Relevance 0 Pain Relevance 0.43
We studied the dopamine (DA) D1 receptor gene and one of its downstream targets, the transcription factor c-Fos.
Regulation (targets) of receptor associated with dopamine
19) Confidence 0.03 Published 2002 Journal J. Chem. Neuroanat. Section Abstract Doc Link 12048106 Disease Relevance 0.11 Pain Relevance 0.44
Effects of selective endothelin ET(A) receptor antagonists on endothelin-1-induced potentiation of cancer pain.
Regulation (Effects) of ) receptor associated with pain, cancer pain and antagonist
20) Confidence 0.03 Published 2004 Journal Eur. J. Pharmacol. Section Title Doc Link 15178362 Disease Relevance 1.17 Pain Relevance 0.85

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