INT124720

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Context Info
Confidence 0.39
First Reported 2005
Last Reported 2009
Negated 2
Speculated 2
Reported most in Body
Documents 2
Total Number 7
Disease Relevance 3.10
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IGFBP3) extracellular region (IGFBP3) nucleus (IGFBP3)
Anatomy Link Frequency
blood 6
IGFBP3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dynorphin 6 89.64 High High
medulla 12 74.92 Quite High
Clonidine 4 66.96 Quite High
Hippocampus 6 51.92 Quite High
cocaine 6 26.48 Quite Low
Neuropeptide 18 10.48 Low Low
nMDA receptor 6 8.72 Low Low
Locus ceruleus 48 5.00 Very Low Very Low Very Low
Dopamine 12 5.00 Very Low Very Low Very Low
Analgesic 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sleep Disorders 414 99.60 Very High Very High Very High
Growth Problems 4 96.52 Very High Very High Very High
Targeted Disruption 258 94.76 High High
Death 60 92.04 High High
Hyperglycemia 6 58.40 Quite High
Congenital Anomalies 6 56.64 Quite High
Sprains And Strains 30 24.12 Low Low
Injury 6 9.36 Low Low
Shock 6 6.64 Low Low
Disease 24 5.56 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore we studied Hcrt KO mice and found that Igfbp3 expression was similar to that of WT mice (Fig. 1) indicating that loss of HCRT peptide itself did not induce changes in Igfbp3 expression.
Neg (not) Regulation (changes) of Gene_expression (expression) of Igfbp3
1) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 0.21 Pain Relevance 0.03
Evaluation of IGFBP3 levels, genotype, and IGFBP3 antibodies in blood and CSF of narcoleptic patients
Regulation (Evaluation) of Gene_expression (levels) of IGFBP3 in blood
2) Confidence 0.28 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 0.50 Pain Relevance 0.04
We investigated whether human narcolepsy is associated with dysregulated IGFBP3 levels in the blood and CSF.
Spec (whether) Regulation (dysregulated) of Gene_expression (levels) of IGFBP3 in blood associated with sleep disorders
3) Confidence 0.28 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 0.49 Pain Relevance 0.04
Evaluation of IGFBP3 levels, genotype, and IGFBP3 antibodies in blood and CSF of narcoleptic patients
Regulation (Evaluation) of Gene_expression (antibodies) of IGFBP3 in blood
4) Confidence 0.28 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 0.51 Pain Relevance 0.04
As hypocretin release is highest at this time of the day (equivalent to the evening in humans), higher IGFBP3 levels may affect hypocretin transmission only at times of highest demand, through the reduction of releasable peptide stores in terminals.
Spec (may) Regulation (affect) of Gene_expression (levels) of IGFBP3
5) Confidence 0.28 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 0.37 Pain Relevance 0.04
Hypocretin cell counts were carried out at 8 weeks of age, and no effect of the hIGFBP3 transgene was noted (595±36 in double HZ (hemizygous) versus 610±67 in Hcrt-ataxin-3/hIGFBP3 HZ/WT, n?
Neg (no) Regulation (effect) of Gene_expression (transgene) of hIGFBP3
6) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 0.80 Pain Relevance 0
Effect of zinc supplementation on growth hormone secretion, IGF-I, IGFBP-3, somatomedin generation, alkaline phosphatase, osteocalcin and growth in prepubertal children with idiopathic short stature.
Regulation (Effect) of Gene_expression (generation) of IGFBP-3 associated with growth problems
7) Confidence 0.10 Published 2005 Journal J. Pediatr. Endocrinol. Metab. Section Title Doc Link 15679071 Disease Relevance 0.23 Pain Relevance 0.07

General Comments

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