INT124736

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Context Info
Confidence 0.31
First Reported 2002
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 6
Total Number 12
Disease Relevance 7.55
Pain Relevance 3.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Insr) endosome (Insr) plasma membrane (Insr)
nucleus (Insr) kinase activity (Insr)
Anatomy Link Frequency
macrophages 4
liver 4
striatum 4
neck 3
adipose tissue 2
Insr (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 224 100.00 Very High Very High Very High
chemokine 28 99.60 Very High Very High Very High
cytokine 85 99.00 Very High Very High Very High
Opioid 23 98.32 Very High Very High Very High
Inflammation 238 97.36 Very High Very High Very High
antagonist 20 97.24 Very High Very High Very High
adenocard 8 92.64 High High
opioid receptor 12 49.28 Quite Low
Inflammatory response 21 47.52 Quite Low
Enkephalin 6 25.00 Low Low
Disease Link Frequency Relevance Heat
Obesity 882 100.00 Very High Very High Very High
Apoptosis 145 100.00 Very High Very High Very High
Head & Neck Cancer 2 98.64 Very High Very High Very High
INFLAMMATION 266 97.36 Very High Very High Very High
Glioma 13 96.72 Very High Very High Very High
Breast Cancer 12 90.00 High High
Hyperinsulinism 28 87.32 High High
Insulin Resistance 238 85.28 High High
Malignant Neoplastic Disease 2 84.32 Quite High
Metastasis 38 79.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Insulin receptor–deficient macrophages exhibit increased susceptibility to lipid-induced apoptosis and reduced expression of matrix metalloproteinase 9
Positive_regulation (induced) of Gene_expression (expression) of Insulin receptor in macrophages associated with metalloproteinase and apoptosis
1) Confidence 0.31 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 1.24 Pain Relevance 0.23
Insulin receptor–deficient macrophages exhibit increased susceptibility to lipid-induced apoptosis and reduced expression of matrix metalloproteinase 9
Positive_regulation (increased) of Gene_expression (expression) of Insulin receptor in macrophages associated with metalloproteinase and apoptosis
2) Confidence 0.31 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 1.24 Pain Relevance 0.23
While HFD induced a highly significant increase of circulating MMP-9 in control animals, this increase was less profound in IR?
Positive_regulation (increase) of Gene_expression (profound) of IR associated with metalloproteinase
3) Confidence 0.27 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 0.43 Pain Relevance 0.56
While HFD induced a highly significant increase of circulating MMP-9 in control animals, this increase was less profound in IR?
Positive_regulation (induced) of Gene_expression (profound) of IR associated with metalloproteinase
4) Confidence 0.27 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 0.43 Pain Relevance 0.58
Nonetheless, this in vitro observation did neither translate into increased numbers of apoptotic macrophages in adipose tissue nor into reduced numbers of circulating monocytes in obese IR?
Neg (nor) Positive_regulation (increased) of Gene_expression (obese) of IR in adipose tissue associated with obesity and apoptosis
5) Confidence 0.27 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 0.75 Pain Relevance 0.15
and IL-6 was reduced in skeletal muscle, but not liver of obese IR?
Neg (not) Positive_regulation (liver) of Neg (not) Gene_expression (liver) of IR in liver associated with obesity
6) Confidence 0.27 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 0.89 Pain Relevance 0.24
This analysis revealed, that basal JNK activity, as assessed by phosphorylation of c-Jun, was significantly reduced in skeletal muscle and exhibited a trend towards reduction in liver of obese IR?
Positive_regulation (liver) of Gene_expression (liver) of IR in liver associated with obesity
7) Confidence 0.27 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 0.78 Pain Relevance 0.25
We previously demonstrated an association between an IR-resistant phenotype and overexpression of IFN/STAT1 pathway in head and neck cancer cell lines [17].
Positive_regulation (overexpression) of Gene_expression (overexpression) of IR in neck associated with head & neck cancer
8) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.77 Pain Relevance 0
Our results suggest that the stimulation of A2A receptors by ginsenosides attenuates the changes in behavior and the increases in AP-1 DNA binding activity, FRA-IR, and proenkephalin gene expression in mouse striatum that are induced by MA.
Positive_regulation (increases) of Gene_expression (expression) of FRA-IR in striatum
9) Confidence 0.10 Published 2005 Journal Behav. Brain Res. Section Abstract Doc Link 15680202 Disease Relevance 0 Pain Relevance 0.25
Potential of endogenously expressed insulin receptors (IR) and PDGFR to act as surrogate protein scaffolds during ERK activation by ?
Positive_regulation (during) of Gene_expression (expressed) of IR
10) Confidence 0.08 Published 2002 Journal BMC Pharmacol Section Body Doc Link PMC88976 Disease Relevance 0.24 Pain Relevance 0.33
MA-induced increases in activator protein (AP)-1 DNA binding activity, Fos-related antigen immunoreactivity (FRA-IR), proenkephalin mRNA expression, and proenkephalin-like immunoreactivity were reduced consistently in the striatum of animals that were pretreated with ginsenosides.
Positive_regulation (increases) of Gene_expression (expression) of FRA-IR in striatum
11) Confidence 0.08 Published 2005 Journal Behav. Brain Res. Section Abstract Doc Link 15680202 Disease Relevance 0 Pain Relevance 0.30
We previously demonstrated an association between an IR-resistant phenotype and overexpression of IFN/STAT1 pathway in head and neck cancer cell lines [17].
Positive_regulation (overexpression) of in head Gene_expression (overexpression) of IR in neck associated with head & neck cancer
12) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.77 Pain Relevance 0

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