INT124737

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Context Info
Confidence 0.20
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.61
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Fosl1) nucleus (Fosl1) DNA binding (Fosl1)
Anatomy Link Frequency
striatum 1
nucleus 1
Fosl1 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 3 97.24 Very High Very High Very High
adenocard 4 92.64 High High
Inflammation 14 59.52 Quite High
Enkephalin 2 25.00 Low Low
cytokine 1 5.00 Very Low Very Low Very Low
Analgesic 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Antiepileptic agent 1 5.00 Very Low Very Low Very Low
Kinase C 1 5.00 Very Low Very Low Very Low
Glutamate 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 38 74.16 Quite High
Hyperplasia 2 69.60 Quite High
INFLAMMATION 14 59.52 Quite High
Skin Cancer 7 52.40 Quite High
Toxicity 3 33.92 Quite Low
Body Weight 2 28.12 Quite Low
Stress 9 5.00 Very Low Very Low Very Low
Bacterial Respiratory Disease 2 5.00 Very Low Very Low Very Low
Reprotox - General 1 1 5.00 Very Low Very Low Very Low
Mycoplasma Infection 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MA-induced increases in activator protein (AP)-1 DNA binding activity, Fos-related antigen immunoreactivity (FRA-IR), proenkephalin mRNA expression, and proenkephalin-like immunoreactivity were reduced consistently in the striatum of animals that were pretreated with ginsenosides.
Positive_regulation (increases) of Fos-related antigen immunoreactivity in striatum
1) Confidence 0.20 Published 2005 Journal Behav. Brain Res. Section Abstract Doc Link 15680202 Disease Relevance 0 Pain Relevance 0.30
As summarized in Figure 1B, in the samples from the basal diet group, TPA treatment induced a 2.8-fold increase in Jun D expression and a 2.5-fold increase in Fra-1 expression in the nucleus, compared to a 1.7-fold increase in Jun D and a 1.6-fold increase in Fra-1 in the Protandim diet group.
Positive_regulation (increase) of Fra-1 in nucleus
2) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2668769 Disease Relevance 0.61 Pain Relevance 0.06

General Comments

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