INT124738

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Context Info
Confidence 0.23
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.73
Pain Relevance 1.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Insr) endosome (Insr) plasma membrane (Insr)
nucleus (Insr) kinase activity (Insr)
Anatomy Link Frequency
macrophages 4
striatum 2
Insr (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 17 99.98 Very High Very High Very High
antagonist 14 99.96 Very High Very High Very High
amygdala 46 99.68 Very High Very High Very High
adenocard 4 92.64 High High
Inflammation 78 88.92 High High
Dynorphin 49 81.52 Quite High
Kappa opioid receptor 50 74.40 Quite High
Nerve growth factor 1 64.32 Quite High
Root ganglion neuron 1 61.76 Quite High
Opioid 3 50.00 Quite Low
Disease Link Frequency Relevance Heat
Obesity 252 100.00 Very High Very High Very High
Stress 58 98.76 Very High Very High Very High
Insulin Resistance 70 96.04 Very High Very High Very High
Disease 53 94.60 High High
Anxiety Disorder 46 94.60 High High
Diabetes Mellitus 22 89.36 High High
INFLAMMATION 86 88.92 High High
Injury 3 81.16 Quite High
Targeted Disruption 27 76.72 Quite High
Apoptosis 32 68.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Another question is why reduced macrophage accumulation in obese IR?
Negative_regulation (reduced) of Positive_regulation (accumulation) of IR in macrophage associated with obesity
1) Confidence 0.23 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 1.26 Pain Relevance 0.04
However, in line with the reduced mRNA expression of macrophage marker genes, immunohistochemical analysis of infiltrating, activated macrophages demonstrated a striking reduction of Mac-2-positive cells in WAT of diet-induced obese IR?
Negative_regulation (reduction) of Positive_regulation (induced) of IR in macrophages associated with obesity
2) Confidence 0.23 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 1.14 Pain Relevance 0
MA-induced increases in activator protein (AP)-1 DNA binding activity, Fos-related antigen immunoreactivity (FRA-IR), proenkephalin mRNA expression, and proenkephalin-like immunoreactivity were reduced consistently in the striatum of animals that were pretreated with ginsenosides.
Negative_regulation (reduced) of Positive_regulation (increases) of FRA-IR in striatum
3) Confidence 0.06 Published 2005 Journal Behav. Brain Res. Section Abstract Doc Link 15680202 Disease Relevance 0 Pain Relevance 0.30
agonists reversed these pathological alterations by increasing insulin receptor binding, countering oxidative stress and ?
Negative_regulation (reversed) of Positive_regulation (increasing) of insulin receptor associated with stress and agonist
4) Confidence 0.05 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2912024 Disease Relevance 0.95 Pain Relevance 0.11
We previously showed that ASV-30 (R2 antagonist) blocked the increase in KORp-ir in the BLA [1], thus we were surprised to see a lack CRF-induced KORp-ir in the BLA of CRF1-R (?
Negative_regulation (blocked) of Positive_regulation (increase) of KORp-ir associated with antagonist and amygdala
5) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2795205 Disease Relevance 0.38 Pain Relevance 0.78

General Comments

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