INT124739

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Context Info
Confidence 0.40
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.45
Pain Relevance 0.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Jun) nucleus (Jun) DNA binding (Jun)
transcription factor binding (Jun)
Jun (Mus musculus)
Pain Link Frequency Relevance Heat
adenocard 4 98.92 Very High Very High Very High
Hippocampus 4 98.32 Very High Very High Very High
Enkephalin 4 96.80 Very High Very High Very High
Inflammatory response 5 91.64 High High
antagonist 3 71.60 Quite High
Opioid 1 68.16 Quite High
Inflammation 13 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Burns 111 99.00 Very High Very High Very High
INFLAMMATION 18 91.24 High High
Injury 63 88.48 High High
Convulsion 1 62.28 Quite High
Epilepsy 1 51.60 Quite High
Urological Neuroanatomy 16 5.00 Very Low Very Low Very Low
Sepsis 4 5.00 Very Low Very Low Very Low
Infection 3 5.00 Very Low Very Low Very Low
Ileus 2 5.00 Very Low Very Low Very Low
Toxicity 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, we have also found that KD diminished KA-induced AP-1 DNA-binding activity, Fos and Jun expression, and phoshorylated form of the three types of JNKs.
Negative_regulation (diminished) of AP-1 Binding (activity) of
1) Confidence 0.40 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16300887 Disease Relevance 0.11 Pain Relevance 0.24
Ginsenosides attenuate methamphetamine-induced behavioral side effects in mice via activation of adenosine A2A receptors: possible involvements of the striatal reduction in AP-1 DNA binding activity and proenkephalin gene expression.
Spec (possible) Negative_regulation (reduction) of AP-1 Binding (binding) of associated with adenocard and enkephalin
2) Confidence 0.17 Published 2005 Journal Behav. Brain Res. Section Title Doc Link 15680202 Disease Relevance 0 Pain Relevance 0.46
B but decreased AP-1 DNA-binding activity of intestinal mucosa in burn mice compared with those of commensal depletion + burn group (Figure 4D).


Negative_regulation (decreased) of AP-1 Binding (activity) of associated with burns
3) Confidence 0.07 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2901327 Disease Relevance 1.33 Pain Relevance 0.05

General Comments

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