INT12475

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Context Info
Confidence 0.77
First Reported 1991
Last Reported 2009
Negated 0
Speculated 3
Reported most in Abstract
Documents 35
Total Number 39
Disease Relevance 3.63
Pain Relevance 23.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (OPRL1) signal transducer activity (OPRL1)
Anatomy Link Frequency
CHO 6
brain 4
amygdala 3
C cells 3
neurons 2
OPRL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
orphanin 171 100.00 Very High Very High Very High
opioid receptor 95 100.00 Very High Very High Very High
Opioid 30 100.00 Very High Very High Very High
Kappa opioid receptor 29 100.00 Very High Very High Very High
opiate 20 100.00 Very High Very High Very High
amygdala 16 100.00 Very High Very High Very High
Spinal cord 14 99.92 Very High Very High Very High
Central nervous system 12 99.68 Very High Very High Very High
Hippocampus 8 99.68 Very High Very High Very High
medulla 12 99.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Schizophrenia 3 99.68 Very High Very High Very High
Neuroblastoma 9 99.58 Very High Very High Very High
Pain 15 97.40 Very High Very High Very High
INFLAMMATION 6 96.56 Very High Very High Very High
Stress 21 94.04 High High
Hyperalgesia 2 93.72 High High
Cognitive Disorder 5 83.20 Quite High
Nociception 2 77.32 Quite High
Recurrence 6 77.04 Quite High
Bordatella Infection 1 64.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The potential interactions of natively expressed mu-opioid and opioid receptor-like (ORL1) receptors were studied by exposing intact BE(2)-C cells to agonists or antagonists for 1 h.
Gene_expression (expressed) of ORL1 in C cells associated with antagonist, agonist, opioid receptor and opioid
1) Confidence 0.77 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10940375 Disease Relevance 0.07 Pain Relevance 0.73
To test this hypothesis, myc-tagged ORL1 and HA-tagged muR are co-expressed in human embryonic kidney (HEK) 293 cells.
Gene_expression (co-expressed) of ORL1 in embryonic kidney
2) Confidence 0.76 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15748148 Disease Relevance 0.09 Pain Relevance 0.54
ORL1 and mu-opioid receptor (muR) are co-expressed in several subpopulations of CNS neurons involved in regulating pain transmission.
Gene_expression (co-expressed) of ORL1 in neurons associated with pain and opioid receptor
3) Confidence 0.76 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15748148 Disease Relevance 0.10 Pain Relevance 0.49
While GAIP is expressed in both NT2 precursor cells and differentiated NT2 neuronal cells, ORL1 is only expressed in differentiated NT2 neurons.
Gene_expression (expressed) of ORL1 in neurons
4) Confidence 0.76 Published 2000 Journal J. Mol. Biol. Section Abstract Doc Link 11090272 Disease Relevance 0 Pain Relevance 0.07
Endogenous expression of opioid receptor-like receptor (ORL1), in human neuroblastoma SK-N-SH cells was demonstrated by binding with nociceptin/ orphanin FQ (N/OFQ).
Gene_expression (expression) of ORL1 in SK-N-SH associated with neuroblastoma, orphanin and opioid receptor
5) Confidence 0.76 Published 1997 Journal Neuroreport Section Abstract Doc Link 9223076 Disease Relevance 0.24 Pain Relevance 0.28
A 60-min activation of mu-or opioid receptor-like 1 (ORL1) opioid receptors natively expressed in BE(2)-C human neuroblastoma cells desensitized both mu- and ORL1 receptor-mediated inhibition of cAMP accumulation.
Gene_expression (expressed) of ORL1 associated with neuroblastoma and opioid receptor
6) Confidence 0.76 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12750434 Disease Relevance 0.19 Pain Relevance 0.82
Following incubation with nociceptin mitogen-activated protein kinase activity was increased by 2-fold in cells expressing the ORL1 receptor.
Gene_expression (expressing) of ORL1 associated with orphanin
7) Confidence 0.76 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9384238 Disease Relevance 0 Pain Relevance 0.55
Human ORL1 receptors expressed in CHO cells selectively bound [125I][Tyr14]nociceptin with a Kd of 2.1 pM and a Bmax of 2.6 pmol/mg protein.
Gene_expression (expressed) of ORL1 in CHO associated with orphanin
8) Confidence 0.76 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9384238 Disease Relevance 0 Pain Relevance 0.70
Nociceptin activation of the human ORL1 receptor expressed in Chinese hamster ovary cells: functional homology with opioid receptors.
Gene_expression (expressed) of ORL1 in ovary associated with orphanin and opioid receptor
9) Confidence 0.76 Published 1997 Journal Eur. J. Pharmacol. Section Title Doc Link 9384238 Disease Relevance 0 Pain Relevance 0.46
Stimulation by nociceptin caused a 2-fold increase in the rate of [35S]GTPgammaS binding to membranes derived from CHO cells expressing the ORL1 receptor.
Gene_expression (expressing) of ORL1 in CHO associated with orphanin
10) Confidence 0.76 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9384238 Disease Relevance 0 Pain Relevance 0.50
To probe the functional homology amongst these receptors, a Chinese hamster ovary (CHO) cell line expressing the human ORL1 receptor has been characterized.
Gene_expression (expressing) of ORL1 in CHO
11) Confidence 0.76 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9384238 Disease Relevance 0 Pain Relevance 0.37
The receptor designated Opioid Receptor-Like 1 (ORL1) is abundantly expressed in the central nervous system (CNS) as well as by cells of the immune system.
Gene_expression (expressed) of ORL1 in immune system associated with central nervous system and opioid
12) Confidence 0.75 Published 2008 Journal J Neuroimmune Pharmacol Section Abstract Doc Link 18247127 Disease Relevance 0.13 Pain Relevance 0.44
This is the first report describing the expression and characterization of an amphibian ORL1 receptor, and contributes to our understanding of the evolution of the opioid system.
Gene_expression (expression) of ORL1 receptor associated with opioid
13) Confidence 0.69 Published 2005 Journal J. Mol. Endocrinol. Section Abstract Doc Link 15691892 Disease Relevance 0 Pain Relevance 0.68
Saturation binding assays on membranes from COS-7 cells transiently expressing the newt ORL1 (nORL) receptor revealed a single, high-affinity (estimated Kd, 0.1974 nM) binding site for the ORL1-specific agonist [3H]orphanin FQ analog ([3H]oFQ).
Gene_expression (expressing) of ORL1 associated with orphanin and agonist
14) Confidence 0.69 Published 2005 Journal J. Mol. Endocrinol. Section Abstract Doc Link 15691892 Disease Relevance 0 Pain Relevance 0.60
Expression for both ORL1 and OFQ is strongest during the early postnatal period, remaining strong in the spinal cord, brainstem, ventral forebrain, and neocortex into the adult.
Gene_expression (Expression) of ORL1 in neocortex associated with medulla and spinal cord
15) Confidence 0.68 Published 2001 Journal J. Chem. Neuroanat. Section Abstract Doc Link 11719021 Disease Relevance 0.22 Pain Relevance 0.77
Expression of orphanin FQ and the opioid receptor-like (ORL1) receptor in the developing human and rat brain.
Gene_expression (Expression) of ORL1 in brain associated with orphanin and opioid receptor
16) Confidence 0.68 Published 2001 Journal J. Chem. Neuroanat. Section Title Doc Link 11719021 Disease Relevance 0.23 Pain Relevance 0.63
Human ORL1 and OFQ expression is observed at 16 weeks gestation, remaining relatively unchanged up to 36 weeks.
Gene_expression (expression) of ORL1
17) Confidence 0.68 Published 2001 Journal J. Chem. Neuroanat. Section Abstract Doc Link 11719021 Disease Relevance 0.19 Pain Relevance 0.67
To help define the relationship between kappa(3) and ORL1 receptors, we utilized BE(2)-C human neuroblastoma cells that natively express functional ORL1 and kappa(3) opioid receptors. (125)I-[Tyr(14)]OFQ/N binds to a single population of receptors in BE(2)-C cells.
Gene_expression (express) of ORL1 in C cells associated with neuroblastoma and opioid receptor
18) Confidence 0.67 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11165763 Disease Relevance 0.17 Pain Relevance 0.54
To test this hypothesis, myc-tagged ORL1 and HA-tagged muR are co-expressed in human embryonic kidney (HEK) 293 cells.
Gene_expression (co-expressed) of ORL1 in embryonic kidney
19) Confidence 0.66 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15748148 Disease Relevance 0.09 Pain Relevance 0.54
DNA sequencing and a database search reveal that the human GAIP gene is located upstream of ORL1 and is oriented in the opposite direction.
Gene_expression (located) of ORL1
20) Confidence 0.66 Published 2000 Journal J. Mol. Biol. Section Abstract Doc Link 11090272 Disease Relevance 0 Pain Relevance 0.14

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