INT124757

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Context Info
Confidence 0.70
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 10
Disease Relevance 2.60
Pain Relevance 2.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
nervous system 2
microglia 2
neurons 1
spinal cord 1
brain 1
Kcnn2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 14 99.52 Very High Very High Very High
Action potential 14 99.40 Very High Very High Very High
monoamine 2 99.28 Very High Very High Very High
Eae 2 98.92 Very High Very High Very High
cva 66 98.80 Very High Very High Very High
Serotonin 2 97.52 Very High Very High Very High
Arthritis 2 96.84 Very High Very High Very High
Raphe 4 96.24 Very High Very High Very High
Inflammation 56 95.08 Very High Very High Very High
Neuronal excitability 6 91.28 High High
Disease Link Frequency Relevance Heat
Injury 20 98.92 Very High Very High Very High
Hemorrhage 6 98.80 Very High Very High Very High
Nervous System Injury 2 97.76 Very High Very High Very High
Arthritis 2 96.84 Very High Very High Very High
INFLAMMATION 62 95.08 Very High Very High Very High
Stroke 126 92.12 High High
Nociception 4 86.60 High High
Apoptosis 36 82.24 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 6 67.64 Quite High
Drug Induced Neurotoxicity 30 57.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We show that SK1, SK2, SK3 and IK1 are all expressed in DRG and spinal cord.
Gene_expression (expressed) of SK2 in spinal cord associated with spinal cord
1) Confidence 0.70 Published 2005 Journal Neuroscience Section Abstract Doc Link 15680700 Disease Relevance 0.55 Pain Relevance 0.59
In rats, the SK2 and SK3 channels are expressed in the ascending monoaminergic systems, in particular in the serotonin (5-HT) neurons of the raphe dorsalis nucleus (RDN).
Gene_expression (expressed) of SK2 in RDN associated with raphe, serotonin and monoamine
2) Confidence 0.69 Published 2009 Journal Brain Res. Section Abstract Doc Link 19446538 Disease Relevance 0 Pain Relevance 0.35
The family of calcium-activated slow-potassium (SK) channels comprises 3 members, the SK1, SK2 and SK3 channels, all expressed in neurons, known to mediate the slow-afterhyperpolarization occurring after action potentials.
Gene_expression (expressed) of SK2 in neurons associated with action potential
3) Confidence 0.69 Published 2009 Journal Brain Res. Section Abstract Doc Link 19446538 Disease Relevance 0 Pain Relevance 0.32
First, we compared transcript expression of KCNN1, KCNN2 and KCNN3 in microglia isolated from rat brain.
Gene_expression (expression) of KCNN2 in brain
4) Confidence 0.68 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819255 Disease Relevance 0.13 Pain Relevance 0.18
KCNN2 expression in activated microglia was especially low; near the limits of detection.
Gene_expression (expression) of KCNN2 in microglia
5) Confidence 0.68 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819255 Disease Relevance 0.28 Pain Relevance 0.10
(iv) SK3 channels (but not SK1 or SK2) contributed to microglial activation, which up-regulated iNOS and NO production, and involved a functional link to signaling through p38 MAP kinase.
Gene_expression (channels) of SK2
6) Confidence 0.59 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819255 Disease Relevance 0.47 Pain Relevance 0.12
(i) Transcripts for all three cloned SK channels (KCNN1, KCNN2, KCNN3) are expressed in microglia, but KCNN3 predominates and is the only channel up-regulated in LPS-activated microglia.
Gene_expression (expressed) of KCNN2 in microglia
7) Confidence 0.59 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819255 Disease Relevance 0.25 Pain Relevance 0.12
There are three mammalian SK channels (KCNN1/SK1, KCNN2/SK2, KCNN3/SK3), which are predominantly expressed in the nervous system.
Gene_expression (expressed) of SK2 in nervous system
8) Confidence 0.53 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819255 Disease Relevance 0.18 Pain Relevance 0.27
There are three mammalian SK channels (KCNN1/SK1, KCNN2/SK2, KCNN3/SK3), which are predominantly expressed in the nervous system.
Gene_expression (expressed) of KCNN2 in nervous system
9) Confidence 0.53 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819255 Disease Relevance 0.18 Pain Relevance 0.27
We show that SK1, SK2, SK3 and IK1 are all expressed in DRG and spinal cord.
Gene_expression (expressed) of SK2 in DRG associated with spinal cord
10) Confidence 0.24 Published 2005 Journal Neuroscience Section Abstract Doc Link 15680700 Disease Relevance 0.55 Pain Relevance 0.59

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