INT12476

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Context Info
Confidence 0.59
First Reported 1991
Last Reported 2010
Negated 3
Speculated 3
Reported most in Abstract
Documents 124
Total Number 130
Disease Relevance 47.95
Pain Relevance 77.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TRPV1) transport (TRPV1) plasma membrane (TRPV1)
lipid metabolic process (TRPV1)
Anatomy Link Frequency
nerve 4
neurons 4
skin 3
DRG 3
basal cell 2
TRPV1 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 734 100.00 Very High Very High Very High
dorsal root ganglion 307 100.00 Very High Very High Very High
antagonist 172 100.00 Very High Very High Very High
Nerve growth factor 122 100.00 Very High Very High Very High
Morphine 70 100.00 Very High Very High Very High
substance P 66 100.00 Very High Very High Very High
potassium channel 48 100.00 Very High Very High Very High
mu opioid receptor 7 100.00 Very High Very High Very High
vanilloid receptor subtype 1 3 100.00 Very High Very High Very High
agonist 201 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 335 100.00 Very High Very High Very High
Targeted Disruption 50 99.96 Very High Very High Very High
Hyperalgesia 116 99.92 Very High Very High Very High
Diabetic Neuropathy 62 99.86 Very High Very High Very High
INFLAMMATION 415 99.84 Very High Very High Very High
Dyspepsia 9 99.84 Very High Very High Very High
Acidosis 4 99.84 Very High Very High Very High
Diabetes Mellitus 180 99.68 Very High Very High Very High
Cough 7 99.64 Very High Very High Very High
Frailty 111 99.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Compound H-Arg-15-15C preferentially inhibits TRPV1, showing marginal block of other neuronal receptors.
Negative_regulation (inhibits) of TRPV1 in neuronal
1) Confidence 0.59 Published 2006 Journal J Pain Section Abstract Doc Link 17018334 Disease Relevance 0.36 Pain Relevance 0.92
Thimerosal decreases TRPV1 activity by oxidation of extracellular sulfhydryl residues.
Negative_regulation (decreases) of TRPV1 associated with qutenza
2) Confidence 0.58 Published 2004 Journal Neurosci. Lett. Section Title Doc Link 15464274 Disease Relevance 0.09 Pain Relevance 0.37
Vanilloids induce lasting, but fully reversible, changes in gene expression, including downregulation of the vanilloid receptor subtype 1.
Negative_regulation (downregulation) of vanilloid receptor subtype 1 associated with vanilloid receptor subtype 1
3) Confidence 0.58 Published 2002 Journal Lancet Neurol Section Abstract Doc Link 12849485 Disease Relevance 0.23 Pain Relevance 0.31
The goal of this study was to determine the effect of inhibition of TRPV1 receptors by capsazepine on the antinociceptive potency of anandamide after intrathecal administration.
Negative_regulation (inhibition) of TRPV1 associated with antinociceptive, intrathecal and potency
4) Confidence 0.57 Published 2008 Journal Pain Section Abstract Doc Link 17533116 Disease Relevance 0.23 Pain Relevance 0.54
The effects of capsaicin and of PMA were absent after pharmacological or genetic inactivation of TRPV1 channels.
Negative_regulation (inactivation) of TRPV1 associated with qutenza
5) Confidence 0.56 Published 2009 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 18930149 Disease Relevance 0 Pain Relevance 0.54
These results support a prominent contribution of PIP2 depletion to the desensitization of TRPV1 and suggest the adaptation as a possible physiological function for the Ca(2+) influx through the channel.
Negative_regulation (desensitization) of TRPV1
6) Confidence 0.56 Published 2009 Journal PLoS Biol. Section Abstract Doc Link 19243225 Disease Relevance 0.19 Pain Relevance 0.31
The inhibitory effect of morphine on TRPV1 was abolished by forskolin and 8-bromo-cAMP.
Negative_regulation (effect) of TRPV1 associated with morphine
7) Confidence 0.54 Published 2007 Journal Mol. Pharmacol. Section Abstract Doc Link 17005903 Disease Relevance 1.34 Pain Relevance 1.56
These data show that at low capsaicin concentrations and other moderate stimuli, PtdIns(4,5)P2 partially inhibits TRPV1 in a cellular context, but this effect is likely to be indirect, because it is not detectable in excised patches.
Negative_regulation (inhibits) of TRPV1 associated with qutenza
8) Confidence 0.52 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17596456 Disease Relevance 0 Pain Relevance 0.47
The PLC inhibitor U73122 and dialysis of PtdIns(4,5)P2 or PtdIns(4)P through the patch pipette inhibited desensitization of TRPV1, indicating that Ca2+-induced activation of PLC contributes to desensitization of TRPV1 by depletion of PtdIns(4,5)P2 and PtdIns(4)P.
Negative_regulation (desensitization) of TRPV1
9) Confidence 0.52 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17596456 Disease Relevance 0 Pain Relevance 0.44
Intravesical RTX decreases both TRPV1 in urothelial cells [3] and the number of suburothelial P2X3 expressing fibers in the human bladder [15].
Negative_regulation (decreases) of TRPV1 in bladder
10) Confidence 0.50 Published 2007 Journal BMC Urol Section Body Doc Link PMC1903357 Disease Relevance 0.23 Pain Relevance 0.28
A recent study shows that piperine, the irritant principle in black pepper, is more efficient than capsaicin in the desensitization of human TRPV1, which suggests that this pharmacological aspect of vanilloids can be dissociated from its potency.
Negative_regulation (desensitization) of TRPV1 associated with qutenza and potency
11) Confidence 0.43 Published 2005 Journal Trends Pharmacol. Sci. Section Abstract Doc Link 16043235 Disease Relevance 0.18 Pain Relevance 0.40
The human TRPV1 splice variant, TRPV1b, lacking exon 7, was cloned from human dorsal root ganglia (DRG) RNA.
Negative_regulation (lacking) of TRPV1b in DRG
12) Confidence 0.43 Published 2006 Journal J. Neurochem. Section Abstract Doc Link 17018028 Disease Relevance 0 Pain Relevance 0.29
We show that RA highly up-regulated the total and cell surface TRPV1 protein expression but the TRPV1 mRNA level was unaffected.
Neg (unaffected) Negative_regulation (unaffected) of TRPV1 associated with rheumatoid arthritis
13) Confidence 0.43 Published 2009 Journal Neurochem. Int. Section Abstract Doc Link 19651168 Disease Relevance 0.70 Pain Relevance 0.17
Here, we report that [L-arginyl]-[N-[2,4-dichlorophenethyl]glycyl]-N-(2,4-dichlorophenethyl) glycinamide (H-Arg-15-15C) is a channel blocker that abrogates capsaicin and pH-evoked TRPV1 channel activity with submicromolar activity.
Negative_regulation (abrogates) of TRPV1 associated with qutenza
14) Confidence 0.43 Published 2006 Journal J Pain Section Abstract Doc Link 17018334 Disease Relevance 0.31 Pain Relevance 0.88
The introduction of an iodine atom on the vanillyl moiety of nonivamide causes a switch in the vanilloid activity (TRPV1 antagonism versus TRPV1 desensitization) and nullifies the aversive properties of capsaicinoids.
Negative_regulation (desensitization) of TRPV1
15) Confidence 0.43 Published 2009 Journal Chem. Biol. Interact. Section Abstract Doc Link 19497416 Disease Relevance 0 Pain Relevance 0
Calcium-dependent desensitization of vanilloid receptor TRPV1: a mechanism possibly involved in analgesia induced by topical application of capsaicin.
Negative_regulation (desensitization) of TRPV1 associated with qutenza, analgesic and analgesia
16) Confidence 0.43 Published 2008 Journal Physiol Res Section Title Doc Link 18481914 Disease Relevance 0.18 Pain Relevance 1.07
This review summarizes the current state of knowledge concerning the mechanisms that underlie the acute capsaicin-induced Ca2+-dependent desensitization of TRPV1 channels and explores to what extent they may contribute to capsaicin-induced analgesia.
Negative_regulation (desensitization) of TRPV1 associated with qutenza and analgesia
17) Confidence 0.43 Published 2008 Journal Physiol Res Section Abstract Doc Link 18481914 Disease Relevance 0.15 Pain Relevance 0.91
The UV-induced MMP-1 expression in HaCaT was also decreased by TRPV1 inhibitors and was facilitated by capsaicin.
Negative_regulation (inhibitors) of TRPV1 associated with qutenza and metalloproteinase
18) Confidence 0.43 Published 2009 Journal J. Cell. Physiol. Section Abstract Doc Link 19206161 Disease Relevance 0.10 Pain Relevance 0.67
This study provides evidence for a role of PKC in reversing capsaicin-induced calcium-dependent desensitization of TRPV1 ion channels.
Negative_regulation (desensitization) of TRPV1 associated with kinase c and qutenza
19) Confidence 0.43 Published 2004 Journal Cell Calcium Section Abstract Doc Link 15003856 Disease Relevance 0.06 Pain Relevance 1.03
Activation of protein kinase C reverses capsaicin-induced calcium-dependent desensitization of TRPV1 ion channels.
Negative_regulation (desensitization) of TRPV1 associated with kinase c and qutenza
20) Confidence 0.43 Published 2004 Journal Cell Calcium Section Title Doc Link 15003856 Disease Relevance 0.10 Pain Relevance 1.11

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