INT124767

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Context Info
Confidence 0.45
First Reported 2005
Last Reported 2005
Negated 1
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 1.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oprm1) mitochondrion (Creb1) plasma membrane (Oprm1)
nucleus (Creb1) DNA binding (Creb1) transcription factor binding (Creb1)
Anatomy Link Frequency
nucleus accumbens 1
Creb1 (Mus musculus)
Oprm1 (Mus musculus)
Pain Link Frequency Relevance Heat
mu opioid receptor 3 100.00 Very High Very High Very High
Morphine 11 97.74 Very High Very High Very High
Ventral tegmentum 1 97.04 Very High Very High Very High
Nucleus accumbens 1 95.84 Very High Very High Very High
Eae 4 87.92 High High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The behavioral differences in response to morphine seen in CREB(alphaDelta) mutant mice are not due to changes in mu opioid receptor (MOR) mRNA expression, as the CREB deletion has no effect on baseline MOR mRNA in three of the brain regions involved in mediating these behaviors: the ventral tegmental area (VTA), nucleus accumbens (NAc), and hypothalamus.
CREB Neg (no) Regulation (effect) of MOR mRNA in nucleus accumbens associated with nucleus accumbens, ventral tegmentum, mu opioid receptor and morphine
1) Confidence 0.45 Published 2005 Journal Brain Res. Section Abstract Doc Link 15680959 Disease Relevance 0 Pain Relevance 1.26

General Comments

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