INT124771

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Context Info
Confidence 0.39
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.98
Pain Relevance 0.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Act1 (Mus musculus)
Pain Link Frequency Relevance Heat
Abeta 3 100.00 Very High Very High Very High
Inflammatory marker 1 98.60 Very High Very High Very High
cINOD 10 98.00 Very High Very High Very High
Inflammation 7 62.60 Quite High
cytokine 1 26.00 Quite Low
isoflurane 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 14 99.40 Very High Very High Very High
Death 4 99.16 Very High Very High Very High
Infection 94 98.30 Very High Very High Very High
INFLAMMATION 8 98.28 Very High Very High Very High
Disease 19 97.56 Very High Very High Very High
Alzheimer's Dementia 3 95.32 Very High Very High Very High
Respiratory Syncytial Virus 112 93.92 High High
Aging 1 85.32 High High
Sprains And Strains 91 71.20 Quite High
Hypoxia 73 57.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For each sample, values obtained were normalized to the levels of actin (ACT1).
Gene_expression (levels) of ACT1
1) Confidence 0.39 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1803011 Disease Relevance 0.13 Pain Relevance 0
A decrease in measured negative and positive RNA was observed in MOI 1 × 10-1 and 1 infections after day 5 (Figure 4C and 4D) which correlated with a progressive decrease in beta actin gene expression, indicative of cell death (Figure 4E).
Gene_expression (expression) of actin gene associated with death and infection
2) Confidence 0.02 Published 2010 Journal Virol J Section Body Doc Link PMC2954858 Disease Relevance 1.61 Pain Relevance 0
Both Ab production (APP, beta- and gamma-secretases) and post-production pathways (those affecting Abeta aggregation or clearance: e.g., IL-1 or alpha1ACT) are potentially involved in ibuprofen and other NSAID anti-AD activities.
Gene_expression (production) of alpha1ACT associated with cinod, disease and abeta
3) Confidence 0.01 Published 2004 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 15681801 Disease Relevance 1.24 Pain Relevance 0.97
Changes (n-fold) in gene expression relative to that of DSY562 (azole-susceptible control isolate) were determined from CgACT1-normalized expression levels.
Spec (determined) Gene_expression (expression) of CgACT1
4) Confidence 0.01 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2607542 Disease Relevance 0 Pain Relevance 0

General Comments

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