INT124772

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Context Info
Confidence 0.45
First Reported 2004
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 8
Disease Relevance 4.92
Pain Relevance 2.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (App) Golgi apparatus (App) plasma membrane (App)
extracellular matrix organization (App) DNA binding (App) cytoplasm (App)
App (Mus musculus)
Pain Link Frequency Relevance Heat
Abeta 7 100.00 Very High Very High Very High
Inflammatory mediators 1 99.24 Very High Very High Very High
cINOD 28 98.50 Very High Very High Very High
Inflammatory marker 1 95.36 Very High Very High Very High
Inflammation 73 88.72 High High
cytokine 11 85.56 High High
Neuronal excitability 3 83.64 Quite High
Inflammatory response 1 80.44 Quite High
long-term potentiation 19 68.96 Quite High
Hippocampus 47 64.32 Quite High
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 357 100.00 Very High Very High Very High
INFLAMMATION 87 99.24 Very High Very High Very High
Targeted Disruption 377 99.04 Very High Very High Very High
Disease 178 96.04 Very High Very High Very High
Amyloid Plaque 92 94.96 High High
Apoptosis 10 91.04 High High
Death 40 88.92 High High
Congenital Anomalies 16 82.80 Quite High
Aging 3 82.08 Quite High
Cytomegalovirus Infection 2 73.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It allows the internalization of several ligands such as ApoE, APP (with the Kunitz inhibitor) and ?
Regulation (internalization) of APP Binding (ligands) of
1) Confidence 0.45 Published 2007 Journal Acta Neuropathol Section Body Doc Link PMC2100431 Disease Relevance 0.83 Pain Relevance 0.09
This strongly suggests a different composition of the vascular deposits in APP and TGF-?
Regulation (different) of APP Binding (composition) of
2) Confidence 0.44 Published 2004 Journal J Neuroinflammation Section Body Doc Link PMC500868 Disease Relevance 0.34 Pain Relevance 0.16
A YAC containing the hAPP gene encoding APP harboring the Swedish mutation, the London mutation or a combination of the two increased the A?
Regulation (containing) of hAPP Binding (gene) of
3) Confidence 0.39 Published 2007 Journal Acta Neuropathol Section Body Doc Link PMC2100431 Disease Relevance 0.60 Pain Relevance 0.06
Alterations in APP intracellular trafficking and localization directly impact A?
Regulation (Alterations) of APP Binding (trafficking) of
4) Confidence 0.39 Published 2011 Journal Mol Brain Section Body Doc Link PMC3022812 Disease Relevance 0.16 Pain Relevance 0.08
However, as the intracellular domain of APP, one important function of AICD is to facilitate the interaction of APP with various cytosolic factors that regulate APP's intracellular trafficking and/or signal transduction function.
Regulation (regulate) of APP Binding (trafficking) of
5) Confidence 0.39 Published 2011 Journal Mol Brain Section Body Doc Link PMC3022812 Disease Relevance 0.23 Pain Relevance 0
Both Ab production (APP, beta- and gamma-secretases) and post-production pathways (those affecting Abeta aggregation or clearance: e.g., IL-1 or alpha1ACT) are potentially involved in ibuprofen and other NSAID anti-AD activities.
Regulation (affecting) of Abeta Binding (aggregation) of associated with cinod, disease and abeta
6) Confidence 0.39 Published 2004 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 15681801 Disease Relevance 1.20 Pain Relevance 0.93
Interestingly, it seems that AICD-mediated APP interaction with different factors is controlled by the phosphorylation state of AICD [135].


Regulation (controlled) of APP Binding (interaction) of
7) Confidence 0.24 Published 2011 Journal Mol Brain Section Body Doc Link PMC3022812 Disease Relevance 0.28 Pain Relevance 0
The mechanism behind these NSAIDs is still controversial and several hypotheses have been raised, including changes in the amyloid precursor protein (APP) metabolism, in Abeta aggregation and a decrease in inflammatory mediators.
Regulation (changes) of Abeta Binding (aggregation) of associated with inflammatory mediators, alzheimer's dementia, cinod and abeta
8) Confidence 0.04 Published 2006 Journal Int. J. Dev. Neurosci. Section Abstract Doc Link 16472958 Disease Relevance 1.30 Pain Relevance 0.77

General Comments

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