INT124774

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Context Info
Confidence 0.44
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.40
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Vcp) cytosol (Vcp) transport (Vcp)
endoplasmic reticulum (Vcp) ATPase activity (Vcp) nucleus (Vcp)
Anatomy Link Frequency
osteoblast 1
Vcp (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 6 100.00 Very High Very High Very High
Spinal cord 6 91.56 High High
Pain 4 88.80 High High
rheumatoid arthritis 4 72.28 Quite High
addiction 2 51.76 Quite High
Nerve growth factor 8 41.88 Quite Low
cytokine 8 5.00 Very Low Very Low Very Low
Eae 5 5.00 Very Low Very Low Very Low
Hippocampus 4 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 4 100.00 Very High Very High Very High
Osteoporosis 11 99.30 Very High Very High Very High
Osteogenic Sarcomas 6 99.06 Very High Very High Very High
Pox Virus Infection 2 98.36 Very High Very High Very High
Injury 7 97.12 Very High Very High Very High
Frontotemporal Dementia 12 97.04 Very High Very High Very High
Contusions 1 96.40 Very High Very High Very High
Bone Disease 114 95.92 Very High Very High Very High
Frailty 7 95.60 Very High Very High Very High
Muscle Disease 14 95.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
B signalling in an osteosarcoma (osteoblast-derived) cell line [19], and that VCP binding to ubiquitylated I-?
VCP Binding (binding) of in osteoblast associated with osteoporosis and osteogenic sarcomas
1) Confidence 0.44 Published 2007 Journal BMC Biochem Section Body Doc Link PMC2106369 Disease Relevance 0.53 Pain Relevance 0.03
VCP is a multifunctional anti-inflammatory protein that can inhibit both pathways of complement activation and bind heparin.
VCP Binding (bind) of associated with inflammation
2) Confidence 0.42 Published 2004 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 15681807 Disease Relevance 1.23 Pain Relevance 0.42
B; RANK-L, RANK-ligand; OPG, osteoprotogerin; VCP, valosin-containing protein; UPS, ubiquitin proteasome system; IKKß, I-?
VCP Binding (ligand) of
3) Confidence 0.34 Published 2007 Journal BMC Biochem Section Body Doc Link PMC2106369 Disease Relevance 1.12 Pain Relevance 0.08
These findings suggest that these residues bind to several different adapter proteins enabling VCP to target specific substrates for proteasomal degradation [27], [28].
VCP Binding (bind) of
4) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2950155 Disease Relevance 0.52 Pain Relevance 0

General Comments

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