INT124813

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Context Info
Confidence 0.37
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 0.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (ADCY6) signal transduction (ADCY6) small molecule metabolic process (ADCY6)
plasma membrane (ADCY6) cilium (ADCY6) GTPase activity (ADCY6)
ADCY6 (Homo sapiens)
Pain Link Frequency Relevance Heat
dopamine receptor 4 99.80 Very High Very High Very High
Kinase C 10 99.18 Very High Very High Very High
Opioid 2 85.40 High High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activation of a novel PKC isoform synergistically enhances D2L dopamine receptor-mediated sensitization of adenylate cyclase type 6.
Negative_regulation (sensitization) of adenylate cyclase type 6 associated with dopamine receptor
1) Confidence 0.37 Published 2005 Journal Cell. Signal. Section Title Doc Link 15683739 Disease Relevance 0 Pain Relevance 0.33
Inhibition of Raf1 modestly inhibited the magnitude of D2L receptor-induced sensitization of AC6; however, activation of PKC robustly enhanced D2L receptor-mediated AC6 sensitization in a Raf1-dependent manner.
Negative_regulation (sensitization) of AC6 associated with kinase c
2) Confidence 0.32 Published 2005 Journal Cell. Signal. Section Abstract Doc Link 15683739 Disease Relevance 0 Pain Relevance 0.40

General Comments

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