INT124815

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Context Info
Confidence 0.37
First Reported 2002
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 10.27
Pain Relevance 3.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Col2a1) extracellular region (Col2a1) cytoplasm (Col2a1)
Anatomy Link Frequency
CII 3
Col2a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Arthritis 489 99.52 Very High Very High Very High
Osteoarthritis 51 98.00 Very High Very High Very High
Inflammation 143 97.92 Very High Very High Very High
rheumatoid arthritis 90 97.92 Very High Very High Very High
Eae 6 95.80 Very High Very High Very High
backache 1 89.56 High High
methotrexate 5 89.20 High High
addiction 1 87.48 High High
Hyperalgesia 4 74.00 Quite High
cytokine 77 63.20 Quite High
Disease Link Frequency Relevance Heat
Immunization 28 100.00 Very High Very High Very High
Arthritis 527 99.52 Very High Very High Very High
Relapsing Polychondritis 62 99.40 Very High Very High Very High
Osteoarthritis 53 98.00 Very High Very High Very High
INFLAMMATION 139 97.92 Very High Very High Very High
Rheumatoid Arthritis 135 97.92 Very High Very High Very High
Pressure And Volume Under Development 55 96.48 Very High Very High Very High
Experimental Arthritis 2 96.40 Very High Very High Very High
Disease 106 95.20 Very High Very High Very High
Arthropathy 20 91.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CIA was induced in 7- to 8-week-old female Lewis rats by immunization with bovine type II collagen.
type II collagen Binding (immunization) of associated with immunization and arthritis
1) Confidence 0.37 Published 2005 Journal Int. Immunopharmacol. Section Abstract Doc Link 15683847 Disease Relevance 1.46 Pain Relevance 0.99
CIA was induced in Dark Agouti rats by means of immunization with collagen type II (CII) emulsified in incomplete Freund's adjuvant.
collagen type II Binding (immunization) of in CII associated with immunization and arthritis
2) Confidence 0.32 Published 2005 Journal Scand. J. Immunol. Section Abstract Doc Link 15787740 Disease Relevance 1.20 Pain Relevance 0.44
Briefly, arthritis in rats was induced by immunization with collagen type II that was dissolved in 0.1 M acetic acid (2 mg/ml) at 4°C overnight and emulsified with an equal volume of CFA.
collagen type II Binding (immunization) of associated with immunization and arthritis
3) Confidence 0.12 Published 2010 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2816374 Disease Relevance 1.02 Pain Relevance 0.35
Arthritis was induced in Lewis rats by immunization with bovine type II collagen.
type II collagen Binding (immunization) of associated with immunization and arthritis
4) Confidence 0.10 Published 2010 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Abstract Doc Link PMC2816374 Disease Relevance 1.29 Pain Relevance 0.39
A major function of the sensitized autoimmune cells is recognition of type II collagen as a substrate [113].
type II collagen Binding (recognition) of
5) Confidence 0.04 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3022224 Disease Relevance 1.36 Pain Relevance 0.66
Our group wanted to test the potential capacity of native COLLII, partially hydrolyzed, in association with GC, to lessen the damage and progression of OA, based on the above.
COLLII Binding (association) of associated with osteoarthritis
6) Confidence 0.03 Published 2008 Journal J Orthop Traumatol Section Body Doc Link PMC2656961 Disease Relevance 0.72 Pain Relevance 0.31
In these studies, mice were first immunized with type II collagen and followed for induction of arthritis.
type II collagen Binding (immunized) of associated with arthritis
7) Confidence 0.03 Published 2007 Journal BMC Complement Altern Med Section Body Doc Link PMC1899520 Disease Relevance 0.76 Pain Relevance 0.25
Further, the animal in group A and B received 2 immunizations with bovine collagen type II (CII), and rats of group C served as controls.
collagen type II Binding (immunizations) of in CII
8) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2811745 Disease Relevance 0.91 Pain Relevance 0.32
Animal models for RP have been described as those immunized with either collagen type II (CII) or matrilin-1 and as models that appear spontaneously [1-3].
collagen type II Binding (immunized) of in CII associated with relapsing polychondritis
9) Confidence 0.02 Published 2002 Journal Arthritis Res Section Body Doc Link PMC128937 Disease Relevance 1.56 Pain Relevance 0.21

General Comments

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