INT124824

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Context Info
Confidence 0.43
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.48
Pain Relevance 1.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Plat) extracellular space (Plat) extracellular region (Plat)
cytoplasm (Plat)
Plat (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 10 99.72 Very High Very High Very High
Dopamine 2 97.64 Very High Very High Very High
Nucleus accumbens 6 94.96 High High
addiction 8 89.40 High High
Disease Link Frequency Relevance Heat
Drug Dependence 8 89.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Conditioned place preference induced by morphine was markedly reduced in mice with a targeted deletion of the tPA gene (tPA-/- mice), being accompanied by a loss of morphine-induced dopamine release.
Negative_regulation (reduced) of Transcription (deletion) of tPA associated with dopamine and morphine
1) Confidence 0.43 Published 2005 Journal J. Pharmacol. Sci. Section Abstract Doc Link 15684570 Disease Relevance 0.24 Pain Relevance 0.77
Conditioned place preference induced by morphine was markedly reduced in mice with a targeted deletion of the tPA gene (tPA-/- mice), being accompanied by a loss of morphine-induced dopamine release.
Negative_regulation (reduced) of Transcription (deletion) of tPA associated with dopamine and morphine
2) Confidence 0.43 Published 2005 Journal J. Pharmacol. Sci. Section Abstract Doc Link 15684570 Disease Relevance 0.24 Pain Relevance 0.77

General Comments

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