INT124825

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Context Info
Confidence 0.70
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 3.15
Pain Relevance 5.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Plat) extracellular space (Plat) extracellular region (Plat)
cytoplasm (Plat)
Anatomy Link Frequency
NAc 4
astrocytes 1
Plat (Mus musculus)
Pain Link Frequency Relevance Heat
narcan 1 99.76 Very High Very High Very High
Nucleus accumbens 26 99.68 Very High Very High Very High
Morphine 34 99.62 Very High Very High Very High
ischemia 46 99.44 Very High Very High Very High
Nicotine 8 98.48 Very High Very High Very High
Dopamine 16 97.68 Very High Very High Very High
addiction 16 96.20 Very High Very High Very High
cytokine 11 96.16 Very High Very High Very High
Inflammation 18 95.80 Very High Very High Very High
cva 22 92.88 High High
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 45 99.44 Very High Very High Very High
Reperfusion Injury 5 99.04 Very High Very High Very High
Stroke 37 98.32 Very High Very High Very High
Drug Dependence 14 96.20 Very High Very High Very High
INFLAMMATION 18 95.80 Very High Very High Very High
Cv General 3 Under Development 13 92.88 High High
Middle Cerebral Artery Infarction 18 91.12 High High
Encephalitis 1 83.60 Quite High
Injury 5 78.48 Quite High
Targeted Disruption 7 73.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A single morphine treatment induced tPA mRNA and protein expression in a naloxone-sensitive manner, which was associated with an increase in the enzyme activity in the nucleus accumbens (NAc).
Transcription (expression) of tPA in NAc associated with nucleus accumbens, narcan and morphine
1) Confidence 0.70 Published 2006 Journal Nihon Arukoru Yakubutsu Igakkai Zasshi Section Abstract Doc Link 16619846 Disease Relevance 0.07 Pain Relevance 0.84
Conditioned place preference induced by morphine was markedly reduced in mice with a targeted deletion of the tPA gene (tPA-/- mice), being accompanied by a loss of morphine-induced dopamine release.
Transcription (deletion) of tPA associated with dopamine and morphine
2) Confidence 0.69 Published 2005 Journal J. Pharmacol. Sci. Section Abstract Doc Link 15684570 Disease Relevance 0.24 Pain Relevance 0.76
Conditioned place preference induced by morphine was markedly reduced in mice with a targeted deletion of the tPA gene (tPA-/- mice), being accompanied by a loss of morphine-induced dopamine release.
Transcription (deletion) of tPA associated with dopamine and morphine
3) Confidence 0.69 Published 2005 Journal J. Pharmacol. Sci. Section Abstract Doc Link 15684570 Disease Relevance 0.24 Pain Relevance 0.77
Single and repeated morphine treatment as well as repeated methamphetamine treatment induced tPA mRNA expression in the nucleus accumbens, which was associated with an increase in the enzyme activity.
Transcription (expression) of tPA in nucleus accumbens associated with nucleus accumbens and morphine
4) Confidence 0.53 Published 2005 Journal J. Pharmacol. Sci. Section Abstract Doc Link 15684570 Disease Relevance 0.25 Pain Relevance 0.71
A single morphine treatment induces tPA mRNA and protein expression in the NAc.
Transcription (expression) of tPA in NAc associated with nucleus accumbens and morphine
5) Confidence 0.53 Published 2008 Journal Nihon Shinkei Seishin Yakurigaku Zasshi Section Abstract Doc Link 18411702 Disease Relevance 0 Pain Relevance 0.83
We employed laser capture microdissection (LCM) combined with RT-PCR to measure tPA and PAI-1 mRNA levels in astrocytes in the IBZ (Fig. 5a) after stroke with or without MSC treatment.
Transcription (levels) of tPA in astrocytes associated with stroke
6) Confidence 0.51 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2815778 Disease Relevance 0.78 Pain Relevance 0
Repeated METH treatment also induces tPA mRNA expression in the NAc.
Transcription (expression) of tPA in NAc associated with nucleus accumbens
7) Confidence 0.39 Published 2008 Journal Nihon Shinkei Seishin Yakurigaku Zasshi Section Abstract Doc Link 18411702 Disease Relevance 0 Pain Relevance 0.96
As described above, upon treatment with t-PA at 3 h after ischemia, reperfusion damage was observed.
Transcription (described) of t-PA associated with reperfusion injury and ischemia
8) Confidence 0.24 Published 2010 Journal Naunyn Schmiedebergs Arch Pharmacol Section Body Doc Link PMC2926440 Disease Relevance 1.57 Pain Relevance 0.82

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