INT124826

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Context Info
Confidence 0.68
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.33
Pain Relevance 2.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Plat) extracellular space (Plat) extracellular region (Plat)
cytoplasm (Plat)
Anatomy Link Frequency
NAc 6
Plat (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 20 99.78 Very High Very High Very High
narcan 1 99.76 Very High Very High Very High
Nucleus accumbens 15 99.68 Very High Very High Very High
Nicotine 4 98.80 Very High Very High Very High
addiction 5 96.52 Very High Very High Very High
midbrain 1 87.72 High High
Ventral tegmentum 1 87.08 High High
Dopamine 10 83.04 Quite High
Antinociceptive 1 77.52 Quite High
Disease Link Frequency Relevance Heat
Drug Dependence 5 96.52 Very High Very High Very High
Targeted Disruption 1 73.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A single morphine treatment induced tPA mRNA and protein expression in a naloxone-sensitive manner, which was associated with an increase in the enzyme activity in the nucleus accumbens (NAc).
Positive_regulation (induced) of Transcription (expression) of tPA in NAc associated with nucleus accumbens, narcan and morphine
1) Confidence 0.68 Published 2006 Journal Nihon Arukoru Yakubutsu Igakkai Zasshi Section Abstract Doc Link 16619846 Disease Relevance 0.07 Pain Relevance 0.84
A single morphine treatment induces tPA mRNA and protein expression in the NAc.
Positive_regulation (induces) of Transcription (expression) of tPA in NAc associated with nucleus accumbens and morphine
2) Confidence 0.51 Published 2008 Journal Nihon Shinkei Seishin Yakurigaku Zasshi Section Abstract Doc Link 18411702 Disease Relevance 0 Pain Relevance 0.83
Single and repeated morphine treatment as well as repeated methamphetamine treatment induced tPA mRNA expression in the nucleus accumbens, which was associated with an increase in the enzyme activity.
Positive_regulation (induced) of Transcription (expression) of tPA in nucleus accumbens associated with nucleus accumbens and morphine
3) Confidence 0.47 Published 2005 Journal J. Pharmacol. Sci. Section Abstract Doc Link 15684570 Disease Relevance 0.25 Pain Relevance 0.71

General Comments

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