INT12484

Context Info Confidence 0.48 First Reported 1983 Last Reported 2010 Negated 2 Speculated 1 Reported most in Abstract Documents 45 Total Number 46 Disease Relevance 15.17 Pain Relevance 24.72

pigmentation (Drd2) plasma membrane (Drd2) signal transducer activity (Drd2)

Anatomy Link Frequency brain 4 nucleus accumbens 1 DA-1 1 striatum 1 anterior pituitary 1 Drd2 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Dopamine 333 100.00 cocaine 191 100.00 addiction 188 100.00 Serotonin 90 100.00 dopamine receptor 62 100.00 Morphine 36 100.00 Opioid 27 100.00 opiate 26 100.00 Analgesic 9 100.00 narcan 9 100.00

Disease Link Frequency Relevance Heat Anxiety Disorder 67 100.00 Opiate Addiction 24 100.00 Vomiting 5 100.00 Depression 39 99.92 Drug Dependence 27 99.80 Urological Neuroanatomy 7 99.78 Alcohol Addiction 187 99.76 Syndrome 72 99.76 Migraine Without Aura 2 99.48 Nociception 3 99.36

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The results suggest that some hydroxy derivatives of aminotetralin have significant interaction with both central alpha 2-adrenoceptor and D2-dopamine receptor systems.

D2-dopamine Binding (interaction) of associated with dopamine receptor

1) Confidence 0.48 Published 1984 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6714312 Disease Relevance 0 Pain Relevance 0.43

On the basis of preliminary experiments, 30 nM spiperone was included in the assay medium in the frontal cortex (to block binding to D2 dopamine and S2 serotonin sites), but not in the hippocampus or cerebellum; the specific binding was defined by inhibition by 30 or 100 microM (+)3-(3-hydroxy)-N-(1-propyl)piperidine.

D2 dopamine Binding (binding) of in hippocampus associated with dopamine, urological neuroanatomy, hippocampus and serotonin

2) Confidence 0.43 Published 1991 Journal Yakubutsu Seishin Kodo Section Abstract Doc Link 1656649 Disease Relevance 0.16 Pain Relevance 0.31

Agonist binding was then studied by examining DA displaceable 3H-spiroperidol (75 pM) binding to the D-2 DA receptor.

D-2 DA receptor Binding (binding) of associated with dopamine and agonist

3) Confidence 0.42 Published 1987 Journal Alcohol Drug Res Section Abstract Doc Link 2431697 Disease Relevance 0 Pain Relevance 1.38

Within patients, the average and maximum daily methadone dose during the first year of treatment and the time when that maximum dose was reached were analyzed for an association with DRD2/ANKK1 genetics.

DRD2 Spec (analyzed) Binding (association) of

4) Confidence 0.39 Published 2009 Journal Pharmacogenet. Genomics Section Body Doc Link 19373123 Disease Relevance 0.08 Pain Relevance 0

We investigated interactions between the opioid analgesic morphine and the anti-emetic metoclopramide, a dopamine D2 receptor antagonist, on nociception and gross motor function. 2.

dopamine D2 receptor Binding (interactions) of associated with nociception, dopamine, antagonist, analgesic, vomiting, opioid and morphine

5) Confidence 0.37 Published 2007 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 17201744 Disease Relevance 0.91 Pain Relevance 1.10

A marginal depression in dopamine D-2 binding in the striatum was noted.

dopamine D-2 Binding (binding) of in striatum associated with dopamine and depression

6) Confidence 0.36 Published 1989 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2542043 Disease Relevance 0.10 Pain Relevance 0.41

Because positive association between DRD2 alleles and alcohol and/or drug dependence has been reported only in populations of European ancestry, we limited the present study to European Americans (EAs).

DRD2 Binding (association) of associated with drug dependence, addiction and alcohol

7) Confidence 0.36 Published 2000 Journal Am. J. Med. Genet. Section Abstract Doc Link 11054774 Disease Relevance 0.78 Pain Relevance 0.92

Phenotypic differences have been associated with DRD2 variants.

DRD2 Binding (associated) of associated with dopamine receptor

8) Confidence 0.35 Published 2000 Journal Pharmacogenomics Section Abstract Doc Link 11256581 Disease Relevance 1.08 Pain Relevance 0.67

Synergistic interaction between dopamine D-1 and D-2 receptor agonists: circling behaviour of rats with hemitransection.

D-2 receptor Binding (interaction) of associated with dopamine and agonist

9) Confidence 0.35 Published 1987 Journal Eur. J. Pharmacol. Section Title Doc Link 3500865 Disease Relevance 0 Pain Relevance 0.37

Together, these studies suggest that the conflicting findings from case-control studies of the association between alleles of DRD2 and substance dependence may be attributable to population stratification in some samples.

DRD2 Binding (association) of associated with drug dependence and addiction

10) Confidence 0.34 Published 2000 Journal Am. J. Med. Genet. Section Abstract Doc Link 11054774 Disease Relevance 0.87 Pain Relevance 0.84

Phenotypic differences have been associated with DRD2 variants.

DRD2 Binding (associated) of associated with dopamine receptor

11) Confidence 0.34 Published 2003 Journal Am. J. Med. Genet. B Neuropsychiatr. Genet. Section Abstract Doc Link 12497624 Disease Relevance 0.80 Pain Relevance 0.87

Neurochem. 78 (2001) 1094] and associates found increases in the dopamine D2 receptors (DRD2) via adenoviral vector delivery of the DRD2 gene into the nucleus accumbens, significantly reduced both ethanol preference (43%) and alcohol intake (64%) of ethanol preferring rats, which recovered as the DRD2, returned to baseline levels.

DRD2 Binding (associates) of in nucleus accumbens associated with nucleus accumbens, dopamine and alcohol

12) Confidence 0.33 Published 2004 Journal Med. Hypotheses Section Abstract Doc Link 15288384 Disease Relevance 0.14 Pain Relevance 0.60

The DRD2 A1 allele has also been shown to associate with heroin addicts in a number of studies.

DRD2 Binding (associate) of

13) Confidence 0.33 Published 2004 Journal Med. Hypotheses Section Abstract Doc Link 15288384 Disease Relevance 0.26 Pain Relevance 0.75

Since 1990, many studies have addressed possible association of DRD2 polymorphism with alcoholism.

DRD2 Binding (association) of associated with alcohol addiction

14) Confidence 0.32 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2829542 Disease Relevance 0.70 Pain Relevance 0.34

The dopamine D2 receptor (DRD2) gene on chromosome 11 (q22-q23) has been found to be associated with increased alcohol consumption through mechanisms involving incentive salience attributions and craving in alcoholic patients.

DRD2 Binding (associated) of associated with dopamine and alcohol

15) Confidence 0.32 Published 2010 Journal BMC Med Genet Section Abstract Doc Link PMC2829542 Disease Relevance 0.48 Pain Relevance 0.62

Antidepressant drugs given repeatedly change the binding of the dopamine D2 receptor agonist, [3H]N-0437, to dopamine D2 receptors in the rat brain.

D2 receptor Binding (binding) of in brain associated with dopamine, antidepressant and agonist

16) Confidence 0.31 Published 1996 Journal Eur. J. Pharmacol. Section Title Doc Link 8813583 Disease Relevance 0 Pain Relevance 0.77

A possible hyper-reactivity of the dopaminergic receptors DRD2 reinforced the evidence regarding this.

DRD2 Binding (reactivity) of

17) Confidence 0.31 Published 2000 Journal Arq Neuropsiquiatr Section Abstract Doc Link 10920424 Disease Relevance 0.65 Pain Relevance 0.40

RESULTS: Compared with the control group, drug users carried more frequently the minor allele of DRD2 SNP rs1076560G>T SNP (P=0.022, odds ratio 2.343) or the ATCT haplotype of DRD2 rs1799978A>G, rs1076560G>T, rs6277C>T, ANKK1 rs1800497C>T (P=0.048, odds ratio 2.23), with similar tendencies for ANKK1 rs1800497C>T (P=0.056, odds ratio 2.12) and the TCCTCTT haplotype of DRD2 rs12364283T>C, rs1799732C del, rs4648317C>T, rs1076560G>T, rs6275C>T, rs6277C>T, and ANKK1 rs1800497C>T (P=0.059, odds ratio 2.31).

DRD2 Binding (rs6277C>T) of

18) Confidence 0.30 Published 2009 Journal Pharmacogenet. Genomics Section Body Doc Link 19373123 Disease Relevance 0.08 Pain Relevance 0

The average and maximum daily methadone doses were significantly associated with the DRD2 rs6275C>T SNP (P=0.016 and 0.005 for average and maximum dose, respectively).

DRD2 Binding (associated) of

19) Confidence 0.30 Published 2009 Journal Pharmacogenet. Genomics Section Body Doc Link 19373123 Disease Relevance 0.06 Pain Relevance 0

Here, we comprehensively analyzed the DRD2 gene locus, and in addition, the ANKK1 rs1800497C>T single nucleotide polymorphism (SNP), formerly known as 'dopamine D2 receptor Taq1A C>T polymorphism', for associations with the risk of opiate addiction and the methadone dosage requirements.

DRD2 Binding (associations) of associated with addiction, dopamine, methadone and opiate

20) Confidence 0.30 Published 2009 Journal Pharmacogenet. Genomics Section Abstract Doc Link 19373123 Disease Relevance 0.17 Pain Relevance 0.52

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