INT12484
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
The results suggest that some hydroxy derivatives of aminotetralin have significant interaction with both central alpha 2-adrenoceptor and D2-dopamine receptor systems. | |||||||||||||||
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On the basis of preliminary experiments, 30 nM spiperone was included in the assay medium in the frontal cortex (to block binding to D2 dopamine and S2 serotonin sites), but not in the hippocampus or cerebellum; the specific binding was defined by inhibition by 30 or 100 microM (+)3-(3-hydroxy)-N-(1-propyl)piperidine. | |||||||||||||||
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Agonist binding was then studied by examining DA displaceable 3H-spiroperidol (75 pM) binding to the D-2 DA receptor. | |||||||||||||||
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Within patients, the average and maximum daily methadone dose during the first year of treatment and the time when that maximum dose was reached were analyzed for an association with DRD2/ANKK1 genetics. | |||||||||||||||
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We investigated interactions between the opioid analgesic morphine and the anti-emetic metoclopramide, a dopamine D2 receptor antagonist, on nociception and gross motor function. 2. | |||||||||||||||
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A marginal depression in dopamine D-2 binding in the striatum was noted. | |||||||||||||||
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Because positive association between DRD2 alleles and alcohol and/or drug dependence has been reported only in populations of European ancestry, we limited the present study to European Americans (EAs). | |||||||||||||||
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Phenotypic differences have been associated with DRD2 variants. | |||||||||||||||
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Synergistic interaction between dopamine D-1 and D-2 receptor agonists: circling behaviour of rats with hemitransection. | |||||||||||||||
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Together, these studies suggest that the conflicting findings from case-control studies of the association between alleles of DRD2 and substance dependence may be attributable to population stratification in some samples. | |||||||||||||||
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Phenotypic differences have been associated with DRD2 variants. | |||||||||||||||
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Neurochem. 78 (2001) 1094] and associates found increases in the dopamine D2 receptors (DRD2) via adenoviral vector delivery of the DRD2 gene into the nucleus accumbens, significantly reduced both ethanol preference (43%) and alcohol intake (64%) of ethanol preferring rats, which recovered as the DRD2, returned to baseline levels. | |||||||||||||||
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The DRD2 A1 allele has also been shown to associate with heroin addicts in a number of studies. | |||||||||||||||
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Since 1990, many studies have addressed possible association of DRD2 polymorphism with alcoholism. | |||||||||||||||
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The dopamine D2 receptor (DRD2) gene on chromosome 11 (q22-q23) has been found to be associated with increased alcohol consumption through mechanisms involving incentive salience attributions and craving in alcoholic patients. | |||||||||||||||
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Antidepressant drugs given repeatedly change the binding of the dopamine D2 receptor agonist, [3H]N-0437, to dopamine D2 receptors in the rat brain. | |||||||||||||||
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A possible hyper-reactivity of the dopaminergic receptors DRD2 reinforced the evidence regarding this. | |||||||||||||||
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RESULTS: Compared with the control group, drug users carried more frequently the minor allele of DRD2 SNP rs1076560G>T SNP (P=0.022, odds ratio 2.343) or the ATCT haplotype of DRD2 rs1799978A>G, rs1076560G>T, rs6277C>T, ANKK1 rs1800497C>T (P=0.048, odds ratio 2.23), with similar tendencies for ANKK1 rs1800497C>T (P=0.056, odds ratio 2.12) and the TCCTCTT haplotype of DRD2 rs12364283T>C, rs1799732C del, rs4648317C>T, rs1076560G>T, rs6275C>T, rs6277C>T, and ANKK1 rs1800497C>T (P=0.059, odds ratio 2.31). | |||||||||||||||
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The average and maximum daily methadone doses were significantly associated with the DRD2 rs6275C>T SNP (P=0.016 and 0.005 for average and maximum dose, respectively). | |||||||||||||||
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Here, we comprehensively analyzed the DRD2 gene locus, and in addition, the ANKK1 rs1800497C>T single nucleotide polymorphism (SNP), formerly known as 'dopamine D2 receptor Taq1A C>T polymorphism', for associations with the risk of opiate addiction and the methadone dosage requirements. | |||||||||||||||
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