INT12485

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Context Info
Confidence 0.48
First Reported 1987
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 17
Total Number 18
Disease Relevance 4.24
Pain Relevance 2.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

ATPase activity (DNAH8) cytoskeleton (DNAH8) cilium (DNAH8)
cytoplasm (DNAH8)
Anatomy Link Frequency
blood 1
bile 1
DNAH8 (Homo sapiens)
Pain Link Frequency Relevance Heat
adenocard 10 100.00 Very High Very High Very High
addiction 3 99.66 Very High Very High Very High
Enkephalin 4 99.54 Very High Very High Very High
Migraine 15 98.96 Very High Very High Very High
Bile 2 98.72 Very High Very High Very High
tetrodotoxin 7 91.16 High High
Calcium channel 12 90.40 High High
ischemia 2 88.72 High High
Pyramidal cell 1 84.88 Quite High
agonist 35 82.84 Quite High
Disease Link Frequency Relevance Heat
Migraine With Aura 11 99.76 Very High Very High Very High
Disease 71 99.12 Very High Very High Very High
Cancer 16 98.76 Very High Very High Very High
Convulsion 11 97.40 Very High Very High Very High
Hypoxia 28 96.16 Very High Very High Very High
Adhesions 1 92.12 High High
Cv Unclassified Under Development 3 88.72 High High
Death 11 88.24 High High
Sleep Disorders 1 86.60 High High
Epilepsy 4 86.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Bafilomycin A1 and concanamycin A had no effect on guinea pig tracheal spontaneous tone, suggesting that relaxation induced by H+-K+ ATPase inhibitors is not due to an interaction with a vacuolar H+ ATPase.
ATPase Binding (interaction) of
1) Confidence 0.48 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8786567 Disease Relevance 0 Pain Relevance 0.09
Novel mutations in the Na+, K+-ATPase pump gene ATP1A2 associated with familial hemiplegic migraine and benign familial infantile convulsions.
ATPase Binding (associated) of associated with convulsion, migraine with aura and migraine
2) Confidence 0.36 Published 2003 Journal Ann. Neurol. Section Title Doc Link 12953268 Disease Relevance 1.11 Pain Relevance 0.96
Temperature dependence of the Na+/K(+)-ATPase activity and of a spin label paramagnetic maleimide derivative (MSL,2,2,6,6-tetramethylpiperidin-1-oxyl-4-maleimide), which shows a selective binding to the reduced sulfhydryl groups of proteins were investigated.
ATPase Binding (binding) of associated with addiction
3) Confidence 0.36 Published 1990 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 2176486 Disease Relevance 0 Pain Relevance 0.13
Thus, the interaction of local anaesthetics with the Ca2+ -ATPase may be moderately specific or non-specific depending on the mechanism of interaction.
ATPase Binding (interaction) of
4) Confidence 0.35 Published 2000 Journal Int J Hyperthermia Section Abstract Doc Link 10669313 Disease Relevance 0 Pain Relevance 0.13
The peptides that show high-affinity interaction with the MDR1-ATPase also interfere strongly with fluorescent dye extrusion catalyzed by the multidrug transporter in intact cells and some have been shown to reverse drug resistance in cultured cells.
ATPase Binding (interaction) of
5) Confidence 0.34 Published 1994 Journal FASEB J. Section Abstract Doc Link 7914178 Disease Relevance 0 Pain Relevance 0.09
Various other suspected effects, for which there are isolated indications, e.g., inhibition of thromboxane synthesis, preload reduction, interaction with the transport of adenosine, and normalization of the sarcolemmal Na+, K(+)-ATPase activity, are probably of subordinate importance.
ATPase Binding (interaction) of associated with adenocard
6) Confidence 0.32 Published 1987 Journal Cardiovasc Drugs Ther Section Abstract Doc Link 3154674 Disease Relevance 0.24 Pain Relevance 0.15
In purified basolateral membranes, 11-fold enriched in Na(+)-K+ ATPase. [3H]idazoxan and [3H]rauwolscine binding was twofold higher than in homogenates ([3H]idazoxan: 87 +/- 19 vs. 45 +/- 23.3 fmol/mg protein, P less than 0.05; [3H]rauwolscine: 56.4 +/- 21.4 vs. 25.2 +/- 7.3 fmol/mg protein, P less than 0.01).
ATPase Binding (binding) of
7) Confidence 0.25 Published 1991 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1648494 Disease Relevance 0 Pain Relevance 0
It is only slowly hydrolyzed by endogenous ATPase and does not inhibit the hydrolysis of ATP indicating that it probably does not bind to the active sites of endogenous ATP hydrolyzing enzymes.
ATPase Binding (hydrolyzed) of
8) Confidence 0.20 Published 1990 Journal J. Urol. Section Abstract Doc Link 2141655 Disease Relevance 0.06 Pain Relevance 0.16
We tested several compounds, including hormonal steroids, bile salts, lipids, and methionine-enkephalin, for their ability to cross-react with two commercially available 125I digoxin RIAs, to inhibit porcine Na+K+ATPase, and to see whether they present the same incubation temperature dependence as human cord serum.
ATPase Spec (whether) Binding (cross-react) of in bile associated with addiction, bile and enkephalin
9) Confidence 0.18 Published 1991 Journal Clin. Chem. Section Abstract Doc Link 1718632 Disease Relevance 0 Pain Relevance 0.32
The interaction of cardiac glycosides with the Na+/K+ ATPase and the consequential effects appear to be highly dependent on the specific CG compound and the subunit makeup of the receiving ATPase [6,26,27].
ATPase Binding (interaction) of
10) Confidence 0.18 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2656898 Disease Relevance 0.45 Pain Relevance 0.04
Some experiments led to the discovery of digoxin-like factor in blood which could bind to a specific receptor on Na+, K(+)-ATPase subunit, showing also the affinity for cardiac glucosides.
ATPase Binding (bind) of in blood
11) Confidence 0.11 Published 1998 Journal Pol J Pharmacol Section Abstract Doc Link 10385921 Disease Relevance 0.27 Pain Relevance 0.13
However disruption of energy status was not essential since similar events were triggered by impairment of the Na+/K+ ATPase (10?
ATPase Neg (impairment) Binding (impairment) of
12) Confidence 0.06 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2137934 Disease Relevance 0.50 Pain Relevance 0.14
Rubidium flux studies measure the activity of the Na/K ATPase.
ATPase Binding (activity) of
13) Confidence 0.03 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1562419 Disease Relevance 0.17 Pain Relevance 0.03
Under these experimental conditions, ouabain-inhibitable basolateral Isc shall associate with Na+/K+-ATPase, tightly coupling with K+ channels.
ATPase Binding (coupling) of
14) Confidence 0.02 Published 2010 Journal Respir Res Section Body Doc Link PMC2889873 Disease Relevance 0 Pain Relevance 0.06
The calcium is released slowly back into the extracellular space through recycling via the Ca2+-ATPase.
ATPase Binding (recycling) of
15) Confidence 0.02 Published 2010 Journal Biochim Biophys Acta Section Body Doc Link PMC2795853 Disease Relevance 0.74 Pain Relevance 0
However, in studies on the Na,K-ATPase where 2-azido was used in a similar way following peptide sequencing it was shown to cross-link to a single residue within the ATP binding site (Tran et al., 1994) suggesting that diffusion of the reactive compound away from the binding site is not a major contaminating factor.


ATPase Binding (link) of
16) Confidence 0.02 Published 2009 Journal Neuropharmacology Section Body Doc Link PMC2613953 Disease Relevance 0 Pain Relevance 0.11
PTX selectively binds to the Na+, K+-ATPase with a Kd of 20 pM [109] and transforms the pump into a channel permeable to monovalent cations with a single-channel conductance of 10 pS [110–113].
ATPase Binding (binds) of
17) Confidence 0.01 Published 2008 Journal Marine Drugs Section Body Doc Link PMC2525493 Disease Relevance 0.40 Pain Relevance 0
Coumarins are a class of LR5 drugs that competitively bind to the ATPase domain of DNA gyrases and are used in the treatment of human cancer (http://www.embl-ebi.ac.uk/interpro/DisplayIproEntry?
ATPase Binding (bind) of associated with cancer
18) Confidence 0.01 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1475714 Disease Relevance 0.29 Pain Relevance 0

General Comments

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