INT124850

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Context Info
Confidence 0.77
First Reported 2001
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 42
Total Number 42
Disease Relevance 14.51
Pain Relevance 0.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Tpt1) extracellular space (Tpt1) transcription factor binding (Tpt1)
cytoplasm (Tpt1)
Anatomy Link Frequency
endothelial cells 3
lungs 3
muscle 1
MCF-7 1
fibroblast 1
Tpt1 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 65 99.76 Very High Very High Very High
Central nervous system 56 99.62 Very High Very High Very High
antagonist 12 96.76 Very High Very High Very High
cINOD 43 95.28 Very High Very High Very High
Inflammation 140 90.72 High High
sodium channel 39 77.76 Quite High
cytokine 63 44.72 Quite Low
agonist 24 44.24 Quite Low
aspirin 2 34.88 Quite Low
cva 3 15.80 Low Low
Disease Link Frequency Relevance Heat
Retinoblastoma 12 99.86 Very High Very High Very High
Apoptosis 432 99.78 Very High Very High Very High
Rheumatoid Arthritis 65 99.76 Very High Very High Very High
Aging 160 99.58 Very High Very High Very High
Acute Erythroblastic Leukemia 13 99.50 Very High Very High Very High
Epstein-barr Virus 3 99.40 Very High Very High Very High
Lung Cancer 13 99.24 Very High Very High Very High
Intestinal Cancer 3 99.06 Very High Very High Very High
Osteochondroma 40 98.92 Very High Very High Very High
Glioma 97 98.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To dissect the role of p21 in sulindac inhibition of intestinal tumor development in Apc1638+/- mice, we quantified p21 expression from Apc+/-, p21+/+, +/- or -/- mice fed sulindac.
Gene_expression (expression) of p21 associated with intestinal cancer
1) Confidence 0.77 Published 2005 Journal Oncogene Section Abstract Doc Link 15688007 Disease Relevance 0.54 Pain Relevance 0.10
This suggested that although the p21+/- mice retained a wild-type allele, this allele was functionally modulated by hypermethylation, and that the inability of sulindac to inhibit tumor formation in Apc+/-, p21+/- mice is likely due to the inability to induce expression of the wild-type, but differentially methylated, p21 allele.
Gene_expression (expression) of p21 associated with cancer
2) Confidence 0.77 Published 2005 Journal Oncogene Section Abstract Doc Link 15688007 Disease Relevance 0.50 Pain Relevance 0.06
To unravel the molecular mechanisms possibly involved in mediating these radiation effects, we initially focused on the P53-P21 pathway for two reasons: first, this pathway is activated in irradiated endothelial cells, as a consequence of DNA double strand breaks and activation of DNA damage-sensing complexes [34] and, second, P21 expression causes cell cycle arrest and premature senescence, including in endothelial cells [35], [36].
Gene_expression (expression) of P21 in endothelial cells associated with aging
3) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2884035 Disease Relevance 0.72 Pain Relevance 0
To test this hypothesis, we silenced P21 expression in HUVEC through lentivirus-mediated delivery of P21shRNA (Figure 7c).
Gene_expression (expression) of P21
4) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2884035 Disease Relevance 0.36 Pain Relevance 0
Irradiation induced the expression of P53 and P21 proteins in endothelial cells, but p53 or p21 deficiency and P21 silencing did not prevent radiation-induced inhibition of sprouting or proliferation.
Gene_expression (expression) of P21 in endothelial cells
5) Confidence 0.56 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2884035 Disease Relevance 0.40 Pain Relevance 0
Irradiation induced the expression of P53 and P21 proteins in endothelial cells, but p53 or p21 deficiency and P21 silencing did not prevent radiation-induced inhibition of sprouting or proliferation.
Gene_expression (deficiency) of p21 in endothelial cells
6) Confidence 0.56 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2884035 Disease Relevance 0.39 Pain Relevance 0
Two pathways are known to induce cell cycle arrest and senescence: the P16-Rb and P53-P21 pathways.
Gene_expression (pathways) of P21 associated with aging
7) Confidence 0.56 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2884035 Disease Relevance 0.87 Pain Relevance 0
Western blotting for P53, P21 and P16 proteins revealed a rapid enhancement of P53 protein followed by an increased in P21 levels, while P16 levels remained unchanged (Figure 7b).
Gene_expression (levels) of P21
8) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2884035 Disease Relevance 0.59 Pain Relevance 0
In the present study, Sox17 decreased the expression of p15, p21, and p57 in adult mouse lungs, and inhibited TGF-?
Gene_expression (expression) of p21 in lungs
9) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0.24 Pain Relevance 0
Whereas expression of p57 was also decreased on lungs from CCSPrtTA/tetO-Sox17 mice maintained on Dox for 3 days, expression of p15 and p21 was similar to controls.
Gene_expression (expression) of p21 in lungs
10) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0 Pain Relevance 0
Since expression of p15 and p21 was decreased in lungs of adult mice following Sox17 expression in respiratory epithelial cells, we sought to determine if Sox17 influences TGF-?
Gene_expression (expression) of p21 in epithelial cells
11) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0 Pain Relevance 0
In untransfected MCF-7 cells, TNFalpha induces the expression of p21 (Figure 3 panel A) and stimulates the proteolytic activation of Bax, an upstream regulatory protein that initiates mitochondrial membrane permeability transition and is surrogate marker for cell death.
Gene_expression (expression) of p21 in MCF-7 associated with death
12) Confidence 0.31 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2856549 Disease Relevance 0.40 Pain Relevance 0
The p21 expression level decreased by 50% in TM10 cells upon SAHA treatment (Fig. 7A).
Gene_expression (expression) of p21
13) Confidence 0.30 Published 2001 Journal Breast Cancer Res Section Body Doc Link PMC13923 Disease Relevance 0 Pain Relevance 0
g/ml were p21/Cip (Pharmingen Inc, San Diego, CA, USA), pRb (IF8), p107 (SD9), p130 (C-20), E2F-1 (C-20), E2F-4(C-20) and PCNA (C-20) (Santa Cruz Biotechnology Inc, Santa Cruz, CA, USA).
Gene_expression (/) of p21
14) Confidence 0.26 Published 2001 Journal Breast Cancer Res Section Body Doc Link PMC13923 Disease Relevance 0.07 Pain Relevance 0
Secondly, although TM10 cells (p53 wt) have lost 64% of their nuclear p21 during SAHA treatment, the remaining 36% of the nuclear p21 plus the continued synthesis of p21 by p53 activity [55,56,57] during the recovery period would maintain TM10 cells in the inhibited state for several days without SAHA.
Gene_expression (synthesis) of p21
15) Confidence 0.26 Published 2001 Journal Breast Cancer Res Section Body Doc Link PMC13923 Disease Relevance 0.11 Pain Relevance 0
Secondly, although TM10 cells (p53 wt) have lost 64% of their nuclear p21 during SAHA treatment, the remaining 36% of the nuclear p21 plus the continued synthesis of p21 by p53 activity [55,56,57] during the recovery period would maintain TM10 cells in the inhibited state for several days without SAHA.
Gene_expression (synthesis) of p21
16) Confidence 0.26 Published 2001 Journal Breast Cancer Res Section Body Doc Link PMC13923 Disease Relevance 0.06 Pain Relevance 0
Perinuclear localization of p21 was detected in only few TM2H cells (p53 null) when both cell lines were immunostained for p21, whereas p21 was localized in both cytoplasmic and nuclear compartments in TM10 cells (p53 wt) (data not shown).
Gene_expression (immunostained) of p21
17) Confidence 0.26 Published 2001 Journal Breast Cancer Res Section Body Doc Link PMC13923 Disease Relevance 0 Pain Relevance 0
Yeo et al. [24] found that HU inhibits the growth of human diploid fibroblasts by inducing increasing p53 and p21 levels in human diploid fibroblast cells.
Gene_expression (levels) of p21 in fibroblast
18) Confidence 0.23 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2898034 Disease Relevance 0 Pain Relevance 0
Similar expression levels were detected for c-Myc, Klf4, Sox2, p53 and p21 genes among the pGFs, mGFs and TTFs, although the expression levels of klf4, p53 and p21 in GFs were slightly higher than in TTFs at passage 6 (Fig. 5C).
Gene_expression (expression) of p21
19) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939066 Disease Relevance 0 Pain Relevance 0
Similar expression levels were detected for c-Myc, Klf4, Sox2, p53 and p21 genes among the pGFs, mGFs and TTFs, although the expression levels of klf4, p53 and p21 in GFs were slightly higher than in TTFs at passage 6 (Fig. 5C).
Gene_expression (expression) of p21
20) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939066 Disease Relevance 0 Pain Relevance 0

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