INT124851

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Context Info
Confidence 0.43
First Reported 2001
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 13
Total Number 14
Disease Relevance 2.92
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Tpt1) extracellular space (Tpt1) transcription factor binding (Tpt1)
cytoplasm (Tpt1)
Anatomy Link Frequency
myoblasts 2
brains 1
lungs 1
neural 1
T cells 1
Tpt1 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 1 97.16 Very High Very High Very High
cINOD 22 96.76 Very High Very High Very High
Potency 6 87.72 High High
midbrain 1 78.32 Quite High
Inflammation 38 50.00 Quite Low
cytokine 30 5.00 Very Low Very Low Very Low
Enkephalin 8 5.00 Very Low Very Low Very Low
Central nervous system 7 5.00 Very Low Very Low Very Low
Crohn's disease 4 5.00 Very Low Very Low Very Low
COX-2 inhibitor 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 226 99.58 Very High Very High Very High
Glioma 46 98.48 Very High Very High Very High
INFLAMMATION 35 96.04 Very High Very High Very High
Repression 19 92.92 High High
Brain Tumor 61 89.32 High High
Aging 36 88.72 High High
Colon Cancer 7 86.64 High High
Intestinal Cancer 2 86.32 High High
Aneuploidy 3 84.76 Quite High
Disease 37 79.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our previous work demonstrated that inactivation of a single p21 allele in Apc1638+/- mice was sufficient to accelerate Apc-initiated tumor formation, and that inactivation of only one p21 allele was also sufficient to abrogate duodenal tumor inhibition by sulindac, a nonsteroidal anti-inflammatory drug.
Negative_regulation (inactivation) of p21 associated with inflammation, cancer and cinod
1) Confidence 0.43 Published 2005 Journal Oncogene Section Abstract Doc Link 15688007 Disease Relevance 0.41 Pain Relevance 0.09
Our previous work demonstrated that inactivation of a single p21 allele in Apc1638+/- mice was sufficient to accelerate Apc-initiated tumor formation, and that inactivation of only one p21 allele was also sufficient to abrogate duodenal tumor inhibition by sulindac, a nonsteroidal anti-inflammatory drug.
Negative_regulation (inactivation) of p21 associated with inflammation, cancer and cinod
2) Confidence 0.43 Published 2005 Journal Oncogene Section Abstract Doc Link 15688007 Disease Relevance 0.50 Pain Relevance 0.10
Absence of p21 did not rescue radiation-induced inhibition of sprouting (15 Gy) compared to non-irradiated rings (Figure S3b).
Negative_regulation (Absence) of p21
3) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2884035 Disease Relevance 0.22 Pain Relevance 0
In addition to increased expression of Sox17 (data not shown), mRNAs for the cyclin-dependent kinase inhibitors p15, p21, and p57 were significantly decreased in lungs of CCSPrtTA/tetO-Sox17 mice relative to CCSPrtTA controls following 1 day of exposure to Dox (Fig. 5).
Negative_regulation (decreased) of p21 in lungs
4) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0 Pain Relevance 0
The p21 expression level decreased by 50% in TM10 cells upon SAHA treatment (Fig. 7A).
Negative_regulation (decreased) of p21
5) Confidence 0.16 Published 2001 Journal Breast Cancer Res Section Body Doc Link PMC13923 Disease Relevance 0 Pain Relevance 0
We identified a novel mechanism for SAHA in cell growth arrest through inhibition in DNA synthesis, concomitant with significant increases in the nuclear localization of pRb-2/p130 associated with E2F-4, decreases in key molecules in DNA synthesis (E2F-1, PCNA and p21), and increases in histone H3 and H4 protein and acetylation levels.
Negative_regulation (decreases) of p21
6) Confidence 0.16 Published 2001 Journal Breast Cancer Res Section Body Doc Link PMC13923 Disease Relevance 0.61 Pain Relevance 0.04
As shown in Figure 2B, inactivation of p53 resulted in a minor reduction of drug effects, whereas inactivation of p21 had no effect.
Negative_regulation (inactivation) of p21
7) Confidence 0.14 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1479836 Disease Relevance 0.55 Pain Relevance 0
Interestingly, loss of p21 increases the proliferative capacity of neural stem cells [114].
Negative_regulation (loss) of p21 in neural
8) Confidence 0.12 Published 2011 Journal Journal of Oncology Section Body Doc Link PMC3010739 Disease Relevance 0.55 Pain Relevance 0.05
Because examination of DM1 cells revealed that both cyclin D3 and cdk4 levels did not increase in DM1 differentiating cells, reduction in formation of the translational complex CUG-BP1-eIF2 provides a reasonable explanation for the reduction in p21 and Mef2A translation in DM1 myoblasts.
Negative_regulation (reduction) of p21 in myoblasts
9) Confidence 0.11 Published 2008 Journal Current Genomics Section Body Doc Link PMC2694559 Disease Relevance 0 Pain Relevance 0
We next examined the cellular distribution of CAPS2 isoform mRNAs in P7 and P21 mouse brains by in situ hybridization analyses.
Spec (examined) Negative_regulation (distribution) of P21 in brains
10) Confidence 0.08 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1853102 Disease Relevance 0 Pain Relevance 0.04
These changes of CUGBP1 phosphorylation in DM1 myogenesis lead to the increase of cyclin D1 in DM1 myoblasts and to the reduction p21 in DM1 myotubes [68] (Fig. 7).
Negative_regulation (reduction) of p21 in myoblasts
11) Confidence 0.06 Published 2010 Journal Current Genomics Section Body Doc Link PMC2874224 Disease Relevance 0.08 Pain Relevance 0
Interestingly, levels of key cell cycle inhibitors p21, p27, and p53 did not significantly differ in control and Gal-4 co-cultured activated T cells (not shown).
Negative_regulation (inhibitors) of p21 in T cells
12) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440804 Disease Relevance 0 Pain Relevance 0
We found that the trityl (Trt) group of His(Trt) is rapidly removed under the thermolytic conditions used to deprotect tert-butyl esters.
Negative_regulation (removed) of Trt
13) Confidence 0.02 Published 2004 Journal PLoS Biology Section Body Doc Link PMC434150 Disease Relevance 0 Pain Relevance 0
We found that the trityl (Trt) group of His(Trt) is rapidly removed under the thermolytic conditions used to deprotect tert-butyl esters.
Negative_regulation (removed) of Trt
14) Confidence 0.02 Published 2004 Journal PLoS Biology Section Body Doc Link PMC434150 Disease Relevance 0 Pain Relevance 0

General Comments

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