INT124852

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Context Info
Confidence 0.50
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 3.95
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Tpt1) extracellular space (Tpt1) transcription factor binding (Tpt1)
cytoplasm (Tpt1)
Anatomy Link Frequency
fibroblast 4
endothelial cells 2
M cell 2
BxPC-3 2
lung 2
Tpt1 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 4 71.44 Quite High
cINOD 6 62.80 Quite High
cva 2 16.16 Low Low
agonist 11 5.00 Very Low Very Low Very Low
Inflammation 5 5.00 Very Low Very Low Very Low
pruritus 5 5.00 Very Low Very Low Very Low
palliative 3 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
metalloproteinase 3 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 103 99.96 Very High Very High Very High
Aging 50 99.44 Very High Very High Very High
Lung Cancer 3 99.24 Very High Very High Very High
Glioma 26 99.00 Very High Very High Very High
Cancer 294 98.64 Very High Very High Very High
Pancreatic Cancer 16 97.64 Very High Very High Very High
Adhesions 17 97.24 Very High Very High Very High
Death 31 90.00 High High
Disease 31 90.00 High High
Metastasis 13 80.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This suggested that although the p21+/- mice retained a wild-type allele, this allele was functionally modulated by hypermethylation, and that the inability of sulindac to inhibit tumor formation in Apc+/-, p21+/- mice is likely due to the inability to induce expression of the wild-type, but differentially methylated, p21 allele.
Positive_regulation (induce) of Gene_expression (expression) of p21 associated with cancer
1) Confidence 0.50 Published 2005 Journal Oncogene Section Abstract Doc Link 15688007 Disease Relevance 0.50 Pain Relevance 0.06
Irradiation induced the expression of P53 and P21 proteins in endothelial cells, but p53 or p21 deficiency and P21 silencing did not prevent radiation-induced inhibition of sprouting or proliferation.
Positive_regulation (induced) of Gene_expression (expression) of P21 in endothelial cells
2) Confidence 0.42 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2884035 Disease Relevance 0.41 Pain Relevance 0
Western blotting for P53, P21 and P16 proteins revealed a rapid enhancement of P53 protein followed by an increased in P21 levels, while P16 levels remained unchanged (Figure 7b).
Positive_regulation (increased) of Gene_expression (levels) of P21
3) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2884035 Disease Relevance 0.59 Pain Relevance 0
Yeo et al. [24] found that HU inhibits the growth of human diploid fibroblasts by inducing increasing p53 and p21 levels in human diploid fibroblast cells.
Positive_regulation (inducing) of Gene_expression (levels) of p21 in fibroblast
4) Confidence 0.17 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2898034 Disease Relevance 0 Pain Relevance 0
Yeo et al. [24] found that HU inhibits the growth of human diploid fibroblasts by inducing increasing p53 and p21 levels in human diploid fibroblast cells.
Positive_regulation (increasing) of Gene_expression (levels) of p21 in fibroblast
5) Confidence 0.17 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2898034 Disease Relevance 0 Pain Relevance 0
Levels of p21 were not affected in MDA-MB231 cells but were slightly increased (1.5-fold) in BT549 cells treated with 5 to 20 ?
Neg (not) Positive_regulation (increased) of Gene_expression (Levels) of p21
6) Confidence 0.12 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206732 Disease Relevance 0.24 Pain Relevance 0.04
Similar expression levels were detected for c-Myc, Klf4, Sox2, p53 and p21 genes among the pGFs, mGFs and TTFs, although the expression levels of klf4, p53 and p21 in GFs were slightly higher than in TTFs at passage 6 (Fig. 5C).
Positive_regulation (detected) of Gene_expression (expression) of p21
7) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939066 Disease Relevance 0 Pain Relevance 0
Similar expression levels were detected for c-Myc, Klf4, Sox2, p53 and p21 genes among the pGFs, mGFs and TTFs, although the expression levels of klf4, p53 and p21 in GFs were slightly higher than in TTFs at passage 6 (Fig. 5C).
Positive_regulation (levels) of Gene_expression (expression) of p21
8) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939066 Disease Relevance 0 Pain Relevance 0
Increased expression of p21 and regression of lung tumor growth in vivo with the administration of decorin has been reported [64].
Positive_regulation (Increased) of Gene_expression (expression) of p21 in lung associated with lung cancer
9) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.98 Pain Relevance 0
Depsipeptide has been shown to induce differentiation, cause G1 and G2/M cell cycle arrest and apoptosis, increase expression of p21 and cyclin E, decrease expression of cyclin D1 and c-myc, and cause hypophosphorylation of Rb (Sandor et al 2000; Picardo et al 2004; Piekarz et al 2004; Piekarz and Bates 2004).
Positive_regulation (increase) of Gene_expression (expression) of p21 in M cell associated with apoptosis
10) Confidence 0.07 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721288 Disease Relevance 0.52 Pain Relevance 0
Therefore we examined the anticancer activities of [6]-gingerol, and investigated its mechanism in two different pancreatic cancer cell lines, HPAC with wt p53 or BxPC-3 with mutant p53. [6]-Gingerol's antiproliferative effects are associated with changes in the expression or phosphorylation of Cyclin A, Cdks, p21 and Rb, and most commonly, causes cell cycle arrest at the G1 phase.
Positive_regulation (changes) of Gene_expression (expression) of p21 in BxPC-3 associated with pancreatic cancer
11) Confidence 0.03 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687755 Disease Relevance 0.71 Pain Relevance 0

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