INT124860

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Context Info
Confidence 0.78
First Reported 2005
Last Reported 2011
Negated 4
Speculated 6
Reported most in Body
Documents 330
Total Number 340
Disease Relevance 157.11
Pain Relevance 31.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Bace1) peptidase activity (Bace1) Golgi apparatus (Bace1)
endoplasmic reticulum (Bace1) enzyme binding (Bace1)
Anatomy Link Frequency
brain 32
cleavage 24
astrocytes 13
neurons 10
hippocampus 8
Bace1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 3615 100.00 Very High Very High Very High
sodium channel 796 100.00 Very High Very High Very High
Nav1.2 358 100.00 Very High Very High Very High
Abeta 12 100.00 Very High Very High Very High
Hippocampus 1634 99.82 Very High Very High Very High
cytokine 1255 99.60 Very High Very High Very High
agonist 484 99.58 Very High Very High Very High
Nav1.1 462 99.22 Very High Very High Very High
glial activation 289 98.64 Very High Very High Very High
Pain 7 98.50 Very High Very High Very High
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 7162 100.00 Very High Very High Very High
INFLAMMATION 4530 100.00 Very High Very High Very High
Injury 1240 100.00 Very High Very High Very High
Urological Neuroanatomy 473 99.98 Very High Very High Very High
Disease 23359 99.92 Very High Very High Very High
Targeted Disruption 9737 99.84 Very High Very High Very High
Stress 6843 99.82 Very High Very High Very High
Neurodegenerative Disease 600 99.76 Very High Very High Very High
Parkinson's Disease 328 99.76 Very High Very High Very High
Apoptosis 2646 99.74 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
deletion lowered BACE1 expression by ?
Gene_expression (expression) of BACE1
1) Confidence 0.78 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2944882 Disease Relevance 0.41 Pain Relevance 0
Although heterozygous knockout also reduced BACE1 expression by ?
Gene_expression (expression) of BACE1 associated with targeted disruption
2) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944882 Disease Relevance 0.23 Pain Relevance 0
genotype significantly reduced BACE1 expression (by ?
Gene_expression (expression) of BACE1
3) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944882 Disease Relevance 0.07 Pain Relevance 0
levels consistent with their normal levels of BACE1 that matched the gene copy number.
Gene_expression (levels) of BACE1
4) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944882 Disease Relevance 0.19 Pain Relevance 0
There is robust expression of BACE1 in the brain during early postnatal development [25,54], during which time, proteolysis of BACE1 substrates may play a role in synapse formation and patterning.
Gene_expression (expression) of BACE1 in brain
5) Confidence 0.78 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2933677 Disease Relevance 0.29 Pain Relevance 0.25
Importantly, we found that BACE1 expression was elevated specifically in the hippocampus of stressed female 5XFAD mice in accordance with increased levels of A?
Gene_expression (expression) of BACE1 in hippocampus associated with hippocampus
6) Confidence 0.77 Published 2010 Journal Mol Brain Section Body Doc Link PMC2988063 Disease Relevance 1.01 Pain Relevance 0.08
Collectively, 5-day exposure to restraint stress induced a marked increase of C99 levels, which was accompanied by significant elevations in both BACE1 and APP expression, specifically in the hippocampus of female 5XFAD mice consistent with the significantly increased A?
Gene_expression (expression) of BACE1 in hippocampus associated with stress and hippocampus
7) Confidence 0.77 Published 2010 Journal Mol Brain Section Body Doc Link PMC2988063 Disease Relevance 0.58 Pain Relevance 0.17
Immunoblot analysis of hippocampal homogenates from male (Figure 3A) and female (Figure 3B) mice demonstrated that 5-day exposure to restraint stress did not change BACE1 levels in male 5XFAD mice (Figure 3C), whereas it increased BACE1 expression in female 5XFAD mice (Figure 3D).
Gene_expression (expression) of BACE1 associated with stress
8) Confidence 0.77 Published 2010 Journal Mol Brain Section Body Doc Link PMC2988063 Disease Relevance 0.66 Pain Relevance 0.14
BACE1 is transported to axons by a kinesin-1-dependent pathway [116] and the highest levels of BACE1 expression are observed when myelination occurs during the early postnatal stages [115].
Gene_expression (expression) of BACE1
9) Confidence 0.77 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.06 Pain Relevance 0.31
BACE1 is initially synthesized in the endoplasmic reticulum (ER) as an immature precursor protein (proBACE1) with a molecular mass of ~60kDa [39, 89-91].
Gene_expression (synthesized) of BACE1 in reticulum
10) Confidence 0.77 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.41 Pain Relevance 0
Moreover, increased BACE1 expression facilitated an enhancement of ?
Gene_expression (expression) of BACE1
11) Confidence 0.77 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.30 Pain Relevance 0
Initial data indicated that the lack of BACE1 expression did not appear to adversely affect embryonic development, nor did it significantly affect the morphology, physiology, biochemistry, and gross behavior of post-natal or adult knockout mice [50, 51].
Gene_expression (expression) of BACE1 associated with targeted disruption
12) Confidence 0.77 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.16 Pain Relevance 0
Indeed, the BACE1 promoter is highly conserved between rodents and humans [176, 177] indicating that regulatory mechanisms of BACE1 expression are shared between these species and that rodents represent useful models in which to study mechanisms and to test therapeutics aimed at reducing BACE1 expression.
Gene_expression (expression) of BACE1
13) Confidence 0.77 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.08 Pain Relevance 0
The activation of specific intracellular signaling molecules appears to be involved in the regulation of BACE1 expression in the brain.
Gene_expression (expression) of BACE1 in brain
14) Confidence 0.77 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.34 Pain Relevance 0
This hypothesis was supported by recent data that demonstrated that during human BACE1 gene expression, ribosomes skipped some uAUGs by leaky scanning and translated an upstream ORF initiated at the fourth uAUG.
Gene_expression (expression) of BACE1 gene associated with contagious ecthyma
15) Confidence 0.77 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.36 Pain Relevance 0
Taken as a whole, the evidence suggests that astrocytes may express significant levels of BACE1 and contribute to A?
Gene_expression (levels) of BACE1 in astrocytes
16) Confidence 0.77 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 1.23 Pain Relevance 0.41
Taken as a whole, the evidence suggests that astrocytes may express significant levels of BACE1 and contribute to A?
Gene_expression (express) of BACE1 in astrocytes
17) Confidence 0.77 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 1.24 Pain Relevance 0.41
In addition to inflammation other conditions may cause BACE1 expression to increase in the brain, including oxidative stress, TBI, hypoxia and ischemia.


Gene_expression (expression) of BACE1 in brain associated with stress, inflammation, hypoxia, ischemia and brain injury
18) Confidence 0.77 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 1.17 Pain Relevance 0.40
However, unlike BACE1, which is enriched in neuronal populations [19], human adult and fetal whole brain express very low or undetectable levels of BACE2 mRNA [28, 74].
Gene_expression (express) of BACE1 in brain
19) Confidence 0.77 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.15 Pain Relevance 0.08
The authors reported that BACE1 expression is regulated by age-dependent post-transcriptional regulatory mechanism in Tg2576 mice.
Gene_expression (expression) of BACE1
20) Confidence 0.77 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.37 Pain Relevance 0

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