INT124861

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Context Info
Confidence 0.09
First Reported 2005
Last Reported 2007
Negated 0
Speculated 0
Reported most in Title
Documents 2
Total Number 2
Disease Relevance 0.75
Pain Relevance 1.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Col5a1) cell adhesion (Col5a1) proteinaceous extracellular matrix (Col5a1)
structural molecule activity (Col5a1)
Col5a1 (Mus musculus)
Pain Link Frequency Relevance Heat
Abeta 8 98.84 Very High Very High Very High
Lamotrigine 8 98.28 Very High Very High Very High
antidepressant 3 97.74 Very High Very High Very High
cINOD 4 95.28 Very High Very High Very High
agonist 2 88.44 High High
Clonidine 1 86.44 High High
antagonist 2 78.24 Quite High
Inflammation 1 65.76 Quite High
depression 1 48.56 Quite Low
anticonvulsant 1 41.96 Quite Low
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 6 99.20 Very High Very High Very High
INFLAMMATION 2 94.56 High High
Disease 1 91.04 High High
Targeted Disruption 1 88.40 High High
Depression 1 48.56 Quite Low
Manic Depressive Disorder 1 45.64 Quite Low
Affective Disorder 1 44.48 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, the present study suggests that the antidepressant-like effect of lamotrigine in the forced swimming test is related to the noradrenergic system, likely due to an activation of alpha1- and alpha2-postsynaptic adrenoceptors.
Positive_regulation (activation) of alpha1 associated with antidepressant and lamotrigine
1) Confidence 0.09 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17433291 Disease Relevance 0 Pain Relevance 0.63
Ibuprofen suppresses interleukin-1beta induction of pro-amyloidogenic alpha1-antichymotrypsin to ameliorate beta-amyloid (Abeta) pathology in Alzheimer's models.
Positive_regulation (induction) of alpha1-antichymotrypsin associated with alzheimer's dementia and abeta
2) Confidence 0.02 Published 2005 Journal Neuropsychopharmacology Section Title Doc Link 15688088 Disease Relevance 0.75 Pain Relevance 0.64

General Comments

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