INT124862

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Context Info
Confidence 0.17
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 2.05
Pain Relevance 2.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Col5a1) cell adhesion (Col5a1) proteinaceous extracellular matrix (Col5a1)
structural molecule activity (Col5a1)
Anatomy Link Frequency
central nervous system 1
interneurons 1
Col5a1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 22 100.00 Very High Very High Very High
Abeta 8 100.00 Very High Very High Very High
gABA 5 99.92 Very High Very High Very High
Neurotransmitter 1 99.76 Very High Very High Very High
noradrenaline 5 99.02 Very High Very High Very High
Chronic pancreatitis 37 98.96 Very High Very High Very High
Analgesic 4 98.92 Very High Very High Very High
Central nervous system 2 98.64 Very High Very High Very High
Clonidine 3 96.80 Very High Very High Very High
fibrosis 9 94.72 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 22 100.00 Very High Very High Very High
Pancreatitis 54 98.96 Very High Very High Very High
Malignant Neoplastic Disease 2 97.84 Very High Very High Very High
Disease 34 97.44 Very High Very High Very High
Fibrosis 8 94.72 High High
Pancreatic Cancer 3 93.40 High High
Alzheimer's Dementia 6 87.04 High High
Nociception 1 85.68 High High
Primary Sclerosing Cholangitis 30 79.60 Quite High
Targeted Disruption 1 79.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This study investigated the analgesic effects of OCSIC and the possible alterations in the expression of gamma-aminobutyric acid type A alpha1 (GABA(A)alpha1) receptors in the central nervous system caused by the compound.
Gene_expression (expression) of alpha1 in central nervous system associated with gaba, analgesic and central nervous system
1) Confidence 0.17 Published 2010 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19818751 Disease Relevance 0.16 Pain Relevance 0.49
These results suggest that NA enhances inhibitory neurotransmitter release by alpha1-adrenoceptors, which are expressed in presynaptic terminals and somatodendritic domains, whereas NA suppresses the excitability of interneurons by alpha2-adrenoceptors, which are expressed in presynaptic somatodendritic domains.
Gene_expression (expressed) of alpha1 in interneurons associated with neurotransmitter and noradrenaline
2) Confidence 0.11 Published 2006 Journal J. Neurophysiol. Section Abstract Doc Link 16251261 Disease Relevance 0 Pain Relevance 0.73
Moreover, the increased expression of collagen V–a collagen type that has been shown to accumulate in malignant disease [40]–and the more diffuse distribution of Tenascin C–an ECM protein that is overexpressed in pancreatic cancer [41]–and of ?
Gene_expression (expression) of collagen V associated with malignant neoplastic disease, pancreatic cancer and disease
3) Confidence 0.11 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440515 Disease Relevance 1.15 Pain Relevance 0.41
To determine whether ibuprofen inhibits pro-amyloidogenic factors, APPsw (Tg2576) mice were treated with ibuprofen for 6 months, and expression levels of the Abeta and inflammation-related molecules alpha1 antichymotrypsin (ACT), apoE, BACE1, and peroxisome proliferator-activated receptor gamma) (PPARgamma) were measured.
Gene_expression (expression) of alpha1 antichymotrypsin associated with inflammation and abeta
4) Confidence 0.02 Published 2005 Journal Neuropsychopharmacology Section Abstract Doc Link 15688088 Disease Relevance 0.74 Pain Relevance 0.70

General Comments

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