INT124874

Context Info Confidence 0.08 First Reported 2005 Last Reported 2007 Negated 1 Speculated 0 Reported most in Abstract Documents 2 Total Number 2 Disease Relevance 0.75 Pain Relevance 1.20

cytoplasm (Gnat3, Calca) aging (Calca) intracellular (Calca) GTPase activity (Gnat3) signal transducer activity (Gnat3) signal transduction (Gnat3)

Gnat3 (Mus musculus) Calca (Rattus norvegicus)

Pain Link Frequency Relevance Heat Calcitonin gene-related peptide 7 100.00 qutenza 7 97.52 headache 3 94.80 fifth nerve 4 93.48 Migraine 2 87.48 antagonist 1 85.76 neuropeptide release 1 84.04

Disease Link Frequency Relevance Heat Increased Venous Pressure Under Development 5 99.98 Headache 5 94.80

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

GTN (2 and 50 microg/kg/min) or NONOate infusion (25 nmol/kg/min) did not cause any CGRP release during and shortly after infusion, whereas administration of capsaicin resulted in strongly increased CGRP levels.

GTN Neg (not) Positive_regulation (cause) of Localization (release) of CGRP associated with qutenza

1) Confidence 0.08 Published 2005 Journal Cephalalgia Section Abstract Doc Link 15689199 Disease Relevance 0.15 Pain Relevance 0.60

The effects of the BK(Ca) channel selective inhibitor iberiotoxin on dural and pial vasodilation induced by CGRP, GTN and endogenously released CGRP by transcranial electrical stimulation (TES) were examined.

GTN Positive_regulation (induced) of Localization (released) of CGRP associated with increased venous pressure under development and calcitonin gene-related peptide

2) Confidence 0.07 Published 2007 Journal Cephalalgia Section Abstract Doc Link 17714519 Disease Relevance 0.61 Pain Relevance 0.61

General Comments

This test has worked.