INT124881

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.47
First Reported 2005
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 35
Total Number 37
Disease Relevance 7.71
Pain Relevance 6.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Trpv4) plasma membrane (Trpv4) cilium (Trpv4)
transmembrane transport (Trpv4)
Anatomy Link Frequency
urinary bladder 1
plasma 1
aorta 1
vesicles 1
ciliary 1
Trpv4 (Mus musculus)
Pain Link Frequency Relevance Heat
TRP channel 209 100.00 Very High Very High Very High
nociceptor 133 100.00 Very High Very High Very High
Hyperalgesia 84 100.00 Very High Very High Very High
Inflammatory mediators 36 99.90 Very High Very High Very High
Thermal hyperalgesia 25 98.68 Very High Very High Very High
Inflammation 131 97.96 Very High Very High Very High
Mechanosensation 12 97.84 Very High Very High Very High
Kinase C 22 93.44 High High
agonist 137 92.40 High High
Neuronal excitability 2 89.04 High High
Disease Link Frequency Relevance Heat
Hyperalgesia 113 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 70 99.80 Very High Very High Very High
INFLAMMATION 163 99.70 Very High Very High Very High
Injury 5 98.84 Very High Very High Very High
Channelopathies 22 97.32 Very High Very High Very High
Neuropathic Pain 66 93.48 High High
Nociception 50 93.44 High High
Pressure And Volume Under Development 46 91.48 High High
Stress 115 87.60 High High
Overactive Bladder 21 87.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings demonstrate that TRPP2 and TRPV4 physically and functionally interact, thereby raising the question of whether TRPP2 nonspecifically alters the activity of TRP channels in vitro.
TRPV4 Binding (interact) of associated with trp channel
1) Confidence 0.47 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2500130 Disease Relevance 0.16 Pain Relevance 0.08
To study whether TRPP2 and TRPV4 also interact functionally, we expressed both channels in Xenopus laevis oocytes for electrophysiological analysis.
TRPV4 Binding (interact) of in oocytes
2) Confidence 0.47 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2500130 Disease Relevance 0.20 Pain Relevance 0.06
So what purpose does this constitutive interaction of AT1aR and TRPV4, or any other 7TMR with an ion channel, serve?
TRPV4 Binding (interaction) of
3) Confidence 0.45 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2943294 Disease Relevance 0 Pain Relevance 0
As shown in Fig. 1, F and G, we detected a constitutive interaction between the AT1aR and TRPV4, and this interaction is not modulated by angiotensin stimulation during the time course examined in this experiment.
TRPV4 Binding (interaction) of
4) Confidence 0.45 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2943294 Disease Relevance 0 Pain Relevance 0
-arrestin 1 interacts with TRPV4 and fine-tunes the level of functional TRPV4 at the cell surface.
TRPV4 Binding (interacts) of
5) Confidence 0.45 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2943294 Disease Relevance 0 Pain Relevance 0.03
However, it is unknown whether TRPV4 or related transient receptor potential channels account for warmth perception under injury-free conditions.
TRPV4 Binding (account) of associated with trp channel, injury and increased venous pressure under development
6) Confidence 0.37 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15689568 Disease Relevance 0.45 Pain Relevance 0.25
Functional interaction between TRPP2 and TRPV4
TRPV4 Binding (interaction) of
7) Confidence 0.36 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2500130 Disease Relevance 0.14 Pain Relevance 0.06
Additional behavioral observations suggested that multiple mediators are necessary to achieve sufficient activation of the cAMP pathway to engage the TRPV4-dependent mechanism of hyperalgesia.
TRPV4-dependent Binding (engage) of associated with hyperalgesia
8) Confidence 0.36 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 16597741 Disease Relevance 1.50 Pain Relevance 1.16
TRPV4 as a target for bladder overactivity

Several papers published in the last 2-3 years suggest that transient receptor potential vanilloid 4 (TRPV4) channels are candidates as mechanosensors in the urinary bladder (including human) and indicate that modulation (inhibition) of these channels could represent a novel therapy for overactive bladder and storage dysfunction.

TRPV4 Binding (target) of in urinary bladder associated with overactive bladder
9) Confidence 0.36 Published 2010 Journal F1000 Biol Rep Section Title Doc Link PMC2948364 Disease Relevance 0.09 Pain Relevance 0.04
Using progressively complex model systems, we demonstrate that coupling between two TRP channels, TRPP2 and TRPV4, creates a polymodal sensory channel complex, both in vitro and in vivo.
TRPV4 Binding (coupling) of associated with trp channel
10) Confidence 0.35 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2500130 Disease Relevance 0.10 Pain Relevance 0.17
These observations led us to speculate that TRPP2 may interact with TRPV4 to mediate tissue-specific functions such as ciliary mechanosensation.
TRPV4 Binding (interact) of in ciliary associated with mechanosensation
11) Confidence 0.35 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2500130 Disease Relevance 0.12 Pain Relevance 0.10
To confirm these coimmunoprecipitation assays, we used fluorescence resonance energy transfer (FRET) to test whether the carboxy-terminal domains of TRPP2 and TRPV4 associate within living cells.
TRPV4 Binding (associate) of
12) Confidence 0.35 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2500130 Disease Relevance 0.05 Pain Relevance 0.08
In yet another approach to confirm internalization of TRPV4 and to investigate whether internalization of TRPV4 translates into a functional down-regulation, we measured 4-?
TRPV4 Spec (whether) Binding (internalization) of
13) Confidence 0.35 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2943294 Disease Relevance 0 Pain Relevance 0.04
As shown in Fig. 4, C and D, angiotensin stimulation promoted a significant interaction between TRPV4 and AIP4.
TRPV4 Binding (interaction) of
14) Confidence 0.35 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2943294 Disease Relevance 0 Pain Relevance 0
Although there exist some examples of heterodimer formation between ion channels and 7TMRs (44–47), our data not only provide the first evidence of direct cross-talk between AT1aR and TRPV4 but also report the first example of formation of a multiprotein complex involving ?
TRPV4 Binding (talk) of
15) Confidence 0.35 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2943294 Disease Relevance 0 Pain Relevance 0.05
We identified TRPV4 as a specific interaction partner of ?
TRPV4 Binding (interaction) of
16) Confidence 0.35 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2943294 Disease Relevance 0 Pain Relevance 0
AT1aR and TRPV4 form a constitutive complex in the plasma membrane, and angiotensin stimulation leads to recruitment of ?
TRPV4 Binding (complex) of in plasma
17) Confidence 0.35 Published 2010 Journal The Journal of Biological Chemistry Section Abstract Doc Link PMC2943294 Disease Relevance 0 Pain Relevance 0
Thus, we first checked whether angiotensin stimulation results in ubiquitination of TRPV4 and whether ?
TRPV4 Binding (ubiquitination) of
18) Confidence 0.35 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2943294 Disease Relevance 0 Pain Relevance 0
As shown in Fig. 1, A and B, angiotensin stimulation led to a robust but transient interaction between TRPV4 and ?
TRPV4 Binding (interaction) of
19) Confidence 0.35 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2943294 Disease Relevance 0 Pain Relevance 0
First, we stimulated rVSMCs with angiotensin for different times, immunoprecipitated TRPV4, and subsequently detected ?
TRPV4 Binding (immunoprecipitated) of
20) Confidence 0.35 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2943294 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox