INT124892

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Context Info
Confidence 0.15
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.93
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ppia) nucleus (Ppia)
Anatomy Link Frequency
pore 1
Ppia (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 6 99.20 Very High Very High Very High
Potency 1 98.30 Very High Very High Very High
Kinase C 40 90.76 High High
IPN 1 69.72 Quite High
addiction 1 41.68 Quite Low
Hippocampus 6 8.96 Low Low
potassium channel 76 5.00 Very Low Very Low Very Low
ischemia 11 5.00 Very Low Very Low Very Low
adenocard 4 5.00 Very Low Very Low Very Low
action potential duration 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myocardial Infarction 38 100.00 Very High Very High Very High
Parkinson's Disease 116 81.92 Quite High
Targeted Disruption 8 78.24 Quite High
Death 5 75.52 Quite High
Apoptosis 18 75.08 Quite High
Inflammatory Pain 1 69.72 Quite High
Rupture 2 67.32 Quite High
Nociception 1 67.16 Quite High
Pressure And Volume Under Development 4 64.16 Quite High
Tumor Necrosis Factor Receptor-associated Periodic Syndrome 1 26.96 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
GeNorm identified CypA and Pgk1 as the most stable pairwise combination of reference genes for the experimental groups four days after ACA treatment (M value for combination of best two genes 0.145), CypA and Gapdh for the groups 7 days after the insult (M value for combination of best two genes 0.097) and CypA and Pgk1 for the 21 day time point (M value for combination of best two genes 0.141).
Negative_regulation (pairwise) of CypA associated with myocardial infarction
1) Confidence 0.15 Published 2008 Journal BMC Mol Biol Section Body Doc Link PMC2430208 Disease Relevance 0.15 Pain Relevance 0
Further studies revealed that the potency of different CsA analogues to inhibit pore opening correlates with their ability to inhibit the peptidyl-prolyl cis-trans isomerase activity within the matrix [49,50] that was subsequently identified as CyP-D [51,52].
Negative_regulation (inhibit) of peptidyl-prolyl cis-trans isomerase in pore associated with potency
2) Confidence 0.06 Published 2007 Journal Biochimica et Biophysica Acta Section Body Doc Link PMC2212780 Disease Relevance 0.64 Pain Relevance 0.05
We found that intracellular application of the cyclosporin A.cyclophilin A complex (CsA.CyP), a specific inhibitor of calcineurin, significantly decreased desensitization of capsaicin- or proton-activated TRPV1-WT currents.
Negative_regulation (decreased) of CyP associated with qutenza
3) Confidence 0.02 Published 2005 Journal J. Biol. Chem. Section Abstract Doc Link 15691846 Disease Relevance 0.14 Pain Relevance 0.47

General Comments

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