INT124904

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Context Info
Confidence 0.01
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.50
Pain Relevance 0.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Adarb1) intracellular (Adarb1) response to stress (Tacr1)
cytoplasm (Tacr1) signal transducer activity (Tacr1) mRNA processing (Adarb1)
Anatomy Link Frequency
spinal cord 1
Tacr1 (Rattus norvegicus)
Adarb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 7 100.00 Very High Very High Very High
Spinal cord 6 99.40 Very High Very High Very High
Pain 7 75.00 Quite High
intrathecal 2 60.16 Quite High
antagonist 2 58.16 Quite High
Catecholamine 1 41.04 Quite Low
qutenza 4 37.28 Quite Low
Dorsal horn 2 25.00 Low Low
antidepressant 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Stress 2 97.60 Very High Very High Very High
Overactive Bladder 3 97.24 Very High Very High Very High
Nociception 3 95.92 Very High Very High Very High
Pain 5 75.00 Quite High
Anxiety Disorder 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Substance P (SP) binding to neurokinin 1 receptors (NK1R) in the spinal cord reportedly plays an important role in the micturition reflex as well as in nociceptive responses.
Substance P Binding (binding) of receptors in spinal cord associated with nociception, overactive bladder, spinal cord and substance p
1) Confidence 0.01 Published 2005 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 15692058 Disease Relevance 0.26 Pain Relevance 0.31
Evidence from pharmacological studies has implicated substance P (SP), a natural ligand of tachykinin NK(1) receptors which can also interact with NK(2) receptors, in the generation of pressor and tachycardic responses to stress.
substance P Binding (interact) of receptors associated with stress and substance p
2) Confidence 0.01 Published 2010 Journal J. Neuroendocrinol. Section Abstract Doc Link 20210847 Disease Relevance 0.24 Pain Relevance 0.31

General Comments

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