INT124920

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Context Info
Confidence 0.58
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.06
Pain Relevance 4.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Slc1a2)
Anatomy Link Frequency
spinal 2
astrocytes 2
spinal cord dorsal horn 2
Slc1a2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 19 100.00 Very High Very High Very High
Antinociceptive 9 100.00 Very High Very High Very High
tolerance 8 100.00 Very High Very High Very High
Morphine 39 99.86 Very High Very High Very High
intrathecal 2 99.52 Very High Very High Very High
Spinal cord 4 99.04 Very High Very High Very High
Endep 16 98.58 Very High Very High Very High
Dorsal horn 3 98.56 Very High Very High Very High
Central nervous system 1 98.16 Very High Very High Very High
agonist 4 96.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 1 64.40 Quite High
INFLAMMATION 1 25.00 Low Low
Overdose 1 5.00 Very Low Very Low Very Low
Dislocations 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results showed that amitriptyline alone did not produce an antinociceptive effect, while morphine alone induced antinociceptive tolerance and down-regulation of spinal glutamate transporters (GLAST, GLT-1, and EAAC1) in the rat spinal cord dorsal horn.
Positive_regulation (induced) of Negative_regulation (down-regulation) of GLT-1 in spinal cord dorsal horn associated with glutamate, dorsal horn, tolerance, antinociceptive, endep, spinal cord and morphine
1) Confidence 0.58 Published 2006 Journal Pain Section Abstract Doc Link 16697108 Disease Relevance 0 Pain Relevance 1.72
In morphine-tolerant rats, acute treatment with PKA inhibitor H89 and PKC inhibitor Gö6805 attenuated morphine tolerance and the morphine-induced CSF glutamate and aspartate elevation, and induced trafficking of GLAST and GLT-1 from cytosol onto the cell surface.
Positive_regulation (induced) of Negative_regulation (trafficking) of GLT-1 associated with glutamate, tolerance and morphine
2) Confidence 0.33 Published 2007 Journal Pain Section Abstract Doc Link 17346885 Disease Relevance 0 Pain Relevance 2.02
Here we show that the downregulation of spinal GTs (EAAC1 and GLT-1) induced by a 6-day intrathecal morphine (10 microg, twice daily) treatment regimen was prevented by co-administration of morphine with 2',5'-dideoxyadenosine (ddA, 1 microg, a broad adenylyl cyclase inhibitor) or H89 (10 microg, a selective protein kinase A inhibitor).
Positive_regulation (induced) of Negative_regulation (downregulation) of GLT-1 in spinal associated with morphine and intrathecal
3) Confidence 0.28 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 15694265 Disease Relevance 0.06 Pain Relevance 0.74
Inhibition of the astrocytic GLT-1 was seen to increase the number of astrocytes responding to synaptic input, and exogenous application of the mGluR5 agonist CHPG caused astrocytic [Ca2+]i elevations in synaptically unresponsive astrocytes.
Positive_regulation (increase) of Negative_regulation (Inhibition) of GLT-1 in astrocytes associated with agonist
4) Confidence 0.05 Published 2010 Journal The European Journal of Neuroscience Section Body Doc Link PMC2909395 Disease Relevance 0 Pain Relevance 0.22

General Comments

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