INT124921

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.56
First Reported 2005
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.67
Pain Relevance 3.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc1a1)
Anatomy Link Frequency
neuronal 2
spinal 2
Slc1a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 28 100.00 Very High Very High Very High
Glutamate 10 100.00 Very High Very High Very High
intrathecal 2 100.00 Very High Very High Very High
excitatory amino acid 5 99.92 Very High Very High Very High
dexamethasone 10 99.74 Very High Very High Very High
antagonist 1 99.16 Very High Very High Very High
Dorsal horn 4 96.32 Very High Very High Very High
Spinal cord 4 95.84 Very High Very High Very High
Antinociceptive 3 93.60 High High
tolerance 5 85.56 High High
Disease Link Frequency Relevance Heat
Nervous System Injury 8 91.76 High High
Nociception 1 71.52 Quite High
INFLAMMATION 1 46.48 Quite Low
Injury 1 44.56 Quite Low
Neuropathic Pain 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The downregulation of EAAC1 was significantly diminished after either the GR antagonist RU38486 (4 > 2 = 0.5 microg = vehicle) or a GR antisense oligonucleotide was administered intrathecally twice daily for postoperative day 1-6.
Negative_regulation (diminished) of Negative_regulation (downregulation) of EAAC1 associated with antagonist
1) Confidence 0.56 Published 2006 Journal Pain Section Abstract Doc Link 16360273 Disease Relevance 0.60 Pain Relevance 0.56
Here we show that the downregulation of spinal GTs (EAAC1 and GLT-1) induced by a 6-day intrathecal morphine (10 microg, twice daily) treatment regimen was prevented by co-administration of morphine with 2',5'-dideoxyadenosine (ddA, 1 microg, a broad adenylyl cyclase inhibitor) or H89 (10 microg, a selective protein kinase A inhibitor).
Negative_regulation (prevented) of Negative_regulation (downregulation) of EAAC1 in spinal associated with morphine and intrathecal
2) Confidence 0.36 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 15694265 Disease Relevance 0.07 Pain Relevance 0.77
DEX co-infusion prevented the downregulation of glial glutamate transporters (GLAST (Glu-Asp transporter) and GLT-1 (Glu transporter-1)), but not the neuronal GT EAAC1 (excitatory amino acid carrier).
Negative_regulation (prevented) of Negative_regulation (downregulation) of EAAC1 in neuronal associated with glutamate, dexamethasone and excitatory amino acid
3) Confidence 0.28 Published 2005 Journal Neuroscience Section Abstract Doc Link 15893883 Disease Relevance 0 Pain Relevance 2.04

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox