INT124922

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Context Info
Confidence 0.35
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.07
Pain Relevance 2.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Slc1a2)
Anatomy Link Frequency
neuronal 2
spinal 2
Slc1a2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 28 100.00 Very High Very High Very High
Glutamate 6 100.00 Very High Very High Very High
intrathecal 2 100.00 Very High Very High Very High
dexamethasone 10 99.74 Very High Very High Very High
excitatory amino acid 5 97.84 Very High Very High Very High
Antinociceptive 3 93.60 High High
tolerance 5 85.56 High High
Analgesic 1 69.24 Quite High
tail-flick 1 56.12 Quite High
nociceptor 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Nociception 1 71.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here we show that the downregulation of spinal GTs (EAAC1 and GLT-1) induced by a 6-day intrathecal morphine (10 microg, twice daily) treatment regimen was prevented by co-administration of morphine with 2',5'-dideoxyadenosine (ddA, 1 microg, a broad adenylyl cyclase inhibitor) or H89 (10 microg, a selective protein kinase A inhibitor).
Negative_regulation (prevented) of Negative_regulation (downregulation) of GLT-1 in spinal associated with morphine and intrathecal
1) Confidence 0.35 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 15694265 Disease Relevance 0.07 Pain Relevance 0.77
DEX co-infusion prevented the downregulation of glial glutamate transporters (GLAST (Glu-Asp transporter) and GLT-1 (Glu transporter-1)), but not the neuronal GT EAAC1 (excitatory amino acid carrier).
Negative_regulation (prevented) of Negative_regulation (downregulation) of GLT-1 in neuronal associated with glutamate, dexamethasone and excitatory amino acid
2) Confidence 0.26 Published 2005 Journal Neuroscience Section Abstract Doc Link 15893883 Disease Relevance 0 Pain Relevance 2.02

General Comments

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