INT124938

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Context Info
Confidence 0.15
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 15
Disease Relevance 3.63
Pain Relevance 1.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (MTNR1B) signal transducer activity (MTNR1B)
Anatomy Link Frequency
lymphocyte 2
MT2 1
bone marrow 1
NK cell 1
immune system 1
MTNR1B (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 260 100.00 Very High Very High Very High
Enkephalin 26 99.08 Very High Very High Very High
antagonist 13 98.92 Very High Very High Very High
Central nervous system 4 97.32 Very High Very High Very High
Inflammation 52 97.08 Very High Very High Very High
antidepressant 34 96.36 Very High Very High Very High
depression 46 91.40 High High
agonist 22 90.88 High High
opiate 14 90.44 High High
Serotonin 19 70.84 Quite High
Disease Link Frequency Relevance Heat
Aging 442 100.00 Very High Very High Very High
Disease 72 99.48 Very High Very High Very High
INFLAMMATION 52 97.08 Very High Very High Very High
Sleep Disorders 11 93.28 High High
Depression 54 91.40 High High
Apoptosis 39 89.56 High High
Immunodeficiency 39 85.40 High High
Stress 39 83.96 Quite High
Cognitive Disorder 13 83.68 Quite High
Bordatella Infection 13 80.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ramelteon showed very high affinity for human MT1 (Mel1a) and MT2 (Mel1b) receptors (expressed in Chinese hamster ovary [CHO] cells), and chick forebrain melatonin receptors (consisting of Mel1a and Mel1c receptors) with Ki values of 14.0, 112, and 23.1 pM, respectively, making the affinities of ramelteon for these receptors 3-16 times higher than those of melatonin.
Gene_expression (expressed) of Mel1b in forebrain
1) Confidence 0.15 Published 2005 Journal Neuropharmacology Section Abstract Doc Link 15695169 Disease Relevance 0.09 Pain Relevance 0.16
Melatonin secretion underlies strict circadian rhythms1 and is regulated via the cAMP signal transduction cascade.2 A variety of animal studies and clinical trials in depressed patients suggest that agomelatine, a synthetic melatonergic MT1 and MT2 receptor agonist4 with 5-HT2C receptor antagonistic properties5 within the CNS, has activating and antidepressant effects.6
Gene_expression (synthetic) of MT2 receptor in MT2 associated with antidepressant and central nervous system
2) Confidence 0.07 Published 2010 Journal Core evidence Section Body Doc Link PMC2899775 Disease Relevance 0.24 Pain Relevance 0.50
Melatonin and T lymphocyte function
Gene_expression (function) of Melatonin in T lymphocyte
3) Confidence 0.04 Published 2005 Journal Immun Ageing Section Body Doc Link PMC1325257 Disease Relevance 0.51 Pain Relevance 0
Melatonin is synthesized by human lymphocytes and this finding adds further support to the hypothesis that melatonin plays a role in the regulation of human the immune system [75].


Gene_expression (synthesized) of Melatonin in lymphocytes
4) Confidence 0.04 Published 2005 Journal Immun Ageing Section Body Doc Link PMC1325257 Disease Relevance 0.21 Pain Relevance 0
Melatonin and cytokine production
Gene_expression (production) of Melatonin associated with cytokine
5) Confidence 0.04 Published 2005 Journal Immun Ageing Section Body Doc Link PMC1325257 Disease Relevance 0.07 Pain Relevance 0.24
Mice kept under constant light, or receiving injections of betaadrenergic blockers (propranolol) to inhibit melatonin synthesis, exhibited an inability to mount a primary antibody response to sheep red blood cells (SRBC), a decreased cellularity in thymus and spleen and a depressed autologous mixed lymphocyte reaction; all these were reversed by melatonin administration at the late afternoon [81].
Gene_expression (synthesis) of melatonin in lymphocyte
6) Confidence 0.03 Published 2005 Journal Immun Ageing Section Body Doc Link PMC1325257 Disease Relevance 0.07 Pain Relevance 0
The decline in the production of a number of hormones associated with aging such as growth hormone (GH), estrogen and dehydroepiandrosterone, as well as of the pineal substance melatonin, have been proposed to play a significant role in contributing to immunosenesecence [5].
Gene_expression (production) of melatonin associated with aging
7) Confidence 0.03 Published 2005 Journal Immun Ageing Section Body Doc Link PMC1325257 Disease Relevance 0.83 Pain Relevance 0.04
This suggests that melatonin promotes the production of met-enkephalin through L-type Ca2+ channel.
Gene_expression (promotes) of melatonin associated with enkephalin
8) Confidence 0.03 Published 2005 Journal Immun Ageing Section Body Doc Link PMC1325257 Disease Relevance 0.21 Pain Relevance 0.29
The increased NK cell number brought about by melatonin administration was attributed partly to the increased production of cytokines by melatonin-stimulated T helper cells.
Gene_expression (production) of melatonin in NK cell associated with cytokine
9) Confidence 0.03 Published 2005 Journal Immun Ageing Section Body Doc Link PMC1325257 Disease Relevance 0.14 Pain Relevance 0.21
In 1986, Maestroni et al. first showed that inhibition of melatonin synthesis causes inhibition of cellular and humoral responses in mice [81].
Gene_expression (synthesis) of melatonin
10) Confidence 0.03 Published 2005 Journal Immun Ageing Section Body Doc Link PMC1325257 Disease Relevance 0.08 Pain Relevance 0
Neutrophils are more responsive than monocytes to AFMK suggesting that melatonin biosynthesis and metabolism participate in the chemical communication among leukocytes.
Gene_expression (biosynthesis) of melatonin in Neutrophils
11) Confidence 0.03 Published 2005 Journal Immun Ageing Section Body Doc Link PMC1325257 Disease Relevance 0.26 Pain Relevance 0.09
There is a possibility that melatonin could act as an autocoid in bone marrow as shown by the demonstration of melatonin synthesis in bone marrow cells of mice and humans [122].
Gene_expression (synthesis) of melatonin in bone marrow
12) Confidence 0.03 Published 2005 Journal Immun Ageing Section Body Doc Link PMC1325257 Disease Relevance 0 Pain Relevance 0.13
Mechanism of action of melatonin in immune responses
Gene_expression (Mechanism) of melatonin
13) Confidence 0.03 Published 2005 Journal Immun Ageing Section Body Doc Link PMC1325257 Disease Relevance 0.40 Pain Relevance 0.03
Great variations in the amplitude of nocturnal melatonin secretions are found among individuals suggesting that some individuals produce significantly less melatonin during lifetime than others; this may have an impact in terms of aging [7,68].
Gene_expression (produce) of melatonin associated with aging
14) Confidence 0.03 Published 2005 Journal Immun Ageing Section Body Doc Link PMC1325257 Disease Relevance 0.31 Pain Relevance 0.04
The diurnal and seasonal changes in the immune system have been shown to correlate with melatonin synthesis and secretion [74].
Gene_expression (synthesis) of melatonin in immune system
15) Confidence 0.03 Published 2005 Journal Immun Ageing Section Body Doc Link PMC1325257 Disease Relevance 0.21 Pain Relevance 0

General Comments

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