INT124940

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Context Info
Confidence 0.36
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 2.29
Pain Relevance 0.90

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plasma membrane (MTNR1A) signal transducer activity (MTNR1A)
Anatomy Link Frequency
forebrain 3
MT2 2
lymphocytes 1
suprachiasmatic nucleus 1
MTNR1A (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 52 99.50 Very High Very High Very High
Dismenorea 1 89.60 High High
headache 6 85.52 High High
opiate 4 69.48 Quite High
dopamine receptor 3 61.52 Quite High
antidepressant 9 47.76 Quite Low
tricyclic antidepressant 3 46.48 Quite Low
gABA 7 43.56 Quite Low
Endep 1 43.20 Quite Low
Nortriptyline 1 40.96 Quite Low
Disease Link Frequency Relevance Heat
Death 1 97.56 Very High Very High Very High
Infection 66 97.12 Very High Very High Very High
Cancer 9 96.68 Very High Very High Very High
Sleep Disorders 32 94.88 High High
Sleep Initiation And Maintenance Disorders 124 91.92 High High
Macromastia 1 90.56 High High
Dysmenorrhea 1 89.60 High High
Hypoactive Sexual Desire Disorder 1 88.72 High High
Headache 6 85.52 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 5 76.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ramelteon showed very high affinity for human MT1 (Mel1a) and MT2 (Mel1b) receptors (expressed in Chinese hamster ovary [CHO] cells), and chick forebrain melatonin receptors (consisting of Mel1a and Mel1c receptors) with Ki values of 14.0, 112, and 23.1 pM, respectively, making the affinities of ramelteon for these receptors 3-16 times higher than those of melatonin.
MT1 Binding (affinity) of in forebrain
1) Confidence 0.36 Published 2005 Journal Neuropharmacology Section Abstract Doc Link 15695169 Disease Relevance 0.09 Pain Relevance 0.08
Ramelteon showed very high affinity for human MT1 (Mel1a) and MT2 (Mel1b) receptors (expressed in Chinese hamster ovary [CHO] cells), and chick forebrain melatonin receptors (consisting of Mel1a and Mel1c receptors) with Ki values of 14.0, 112, and 23.1 pM, respectively, making the affinities of ramelteon for these receptors 3-16 times higher than those of melatonin.
Mel1a Binding (affinity) of in forebrain
2) Confidence 0.36 Published 2005 Journal Neuropharmacology Section Abstract Doc Link 15695169 Disease Relevance 0.09 Pain Relevance 0.17
Ramelteon showed very high affinity for human MT1 (Mel1a) and MT2 (Mel1b) receptors (expressed in Chinese hamster ovary [CHO] cells), and chick forebrain melatonin receptors (consisting of Mel1a and Mel1c receptors) with Ki values of 14.0, 112, and 23.1 pM, respectively, making the affinities of ramelteon for these receptors 3-16 times higher than those of melatonin.
Mel1a Binding (affinity) of in forebrain
3) Confidence 0.36 Published 2005 Journal Neuropharmacology Section Abstract Doc Link 15695169 Disease Relevance 0.09 Pain Relevance 0.11
This agonist developed by Eli Lilly also diplays a high affinity towards MT1 und MT2 receptors (Ki = 81 pM for MT1 bzw. 42 pM for MT2).
MT1 Binding (affinity) of in MT2 associated with agonist
4) Confidence 0.21 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2699659 Disease Relevance 0 Pain Relevance 0.05
This agonist developed by Eli Lilly also diplays a high affinity towards MT1 und MT2 receptors (Ki = 81 pM for MT1 bzw. 42 pM for MT2).
MT1 Binding (affinity) of in MT2 associated with agonist
5) Confidence 0.18 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2699659 Disease Relevance 0 Pain Relevance 0.05
Melatonin also counteracted the inhibitory effect of prostaglandin E2 on IL-2 production in human lymphocytes via its MT1 membrane receptor [125].
MT1 Binding (receptor) of in lymphocytes
6) Confidence 0.09 Published 2005 Journal Immun Ageing Section Body Doc Link PMC1325257 Disease Relevance 0.28 Pain Relevance 0.11
0.04 for MT1; RR?
MT1 Binding (0.04) of
7) Confidence 0.06 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2821909 Disease Relevance 0.44 Pain Relevance 0
A melatonin agonist, it acts by selectively binding to the melatonin receptors (MT1, MT2) in the suprachiasmatic nucleus (SCN).
MT1 Binding (binding) of in suprachiasmatic nucleus associated with agonist
8) Confidence 0.04 Published 2010 Journal Annals of Indian Academy of Neurology Section Body Doc Link PMC2924526 Disease Relevance 1.29 Pain Relevance 0.32

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