INT124953

Context Info Confidence 0.42 First Reported 2005 Last Reported 2008 Negated 1 Speculated 2 Reported most in Body Documents 6 Total Number 8 Disease Relevance 1.97 Pain Relevance 1.75

endosome (Egfr) cell morphogenesis (Egfr) intracellular (Egfr) enzyme binding (Egfr) cytoplasm (Egfr) signal transducer activity (Egfr)

Anatomy Link Frequency basal layer 2 Schwann cells 2 Egfr (Rattus norvegicus)

Pain Link Frequency Relevance Heat cINOD 24 99.14 Inflammation 115 62.52 cytokine 63 42.08 COX2 6 25.00 Pain 3 5.36 Inflammatory mediators 24 5.00 Sciatic nerve 17 5.00 chemokine 17 5.00 Inflammatory response 11 5.00 Spinal cord 10 5.00

Disease Link Frequency Relevance Heat Cholesteatoma 48 99.96 Leukemia 1 95.68 Injury 26 94.40 Cancer 4 93.00 Hyperplasia 4 90.72 Apoptosis 9 86.60 Reprotox - General 1 3 80.40 Metaplasia 4 69.16 Infection 14 63.92 INFLAMMATION 151 62.52

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The levels of c-erbB receptor expression by Schwann cells, and the degree to which axons regenerated into the distal stumps both decreased with an increased period of denervation.

Negative_regulation (decreased) of Gene_expression (expression) of erbB in Schwann cells

1) Confidence 0.42 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2556676 Disease Relevance 0.26 Pain Relevance 0

Immunohistochemical and Western blot analysis were done to determine COX-2, epidermal growth factor receptor (EGFR), Akt, androgen receptor, and cyclin D1 expression.

Spec (determine) Negative_regulation (determine) of Gene_expression (expression) of epidermal growth factor receptor

2) Confidence 0.40 Published 2007 Journal Clin. Cancer Res. Section Body Doc Link 17908994 Disease Relevance 0.08 Pain Relevance 0

Immunohistochemical and Western blot analysis were done to determine COX-2, epidermal growth factor receptor (EGFR), Akt, androgen receptor, and cyclin D1 expression.

Spec (determine) Negative_regulation (determine) of Gene_expression (expression) of EGFR

3) Confidence 0.40 Published 2007 Journal Clin. Cancer Res. Section Body Doc Link 17908994 Disease Relevance 0.08 Pain Relevance 0

A strong inhibition of total and phosphorylated form of EGFR (Tyr(992) and Tyr(845)) and Akt (Ser(473)) was significant in rats given with these agents in combination.

Negative_regulation (inhibition) of Gene_expression (form) of EGFR

4) Confidence 0.40 Published 2007 Journal Clin. Cancer Res. Section Body Doc Link 17908994 Disease Relevance 0.05 Pain Relevance 0

Patients on either NSAID or COX-2 therapy had an increased p53 and decreased EGFR expression.

Negative_regulation (decreased) of Gene_expression (expression) of EGFR associated with cinod

5) Confidence 0.22 Published 2005 Journal Int J Immunopathol Pharmacol Section Abstract Doc Link 15698513 Disease Relevance 0.22 Pain Relevance 0.59

PPI therapy reversed not only the increased cell proliferation and p53 expression, but also the suppressed EGFR expression when administered as co-therapy.

Negative_regulation (reversed) of Gene_expression (expression) of EGFR

6) Confidence 0.22 Published 2005 Journal Int J Immunopathol Pharmacol Section Abstract Doc Link 15698513 Disease Relevance 0.22 Pain Relevance 0.59

PPI therapy reversed not only the increased cell proliferation and p53 expression, but also the suppressed EGFR expression when administered as co-therapy.

Negative_regulation (suppressed) of Gene_expression (expression) of EGFR

7) Confidence 0.22 Published 2005 Journal Int J Immunopathol Pharmacol Section Abstract Doc Link 15698513 Disease Relevance 0.21 Pain Relevance 0.57

In cholesteatoma, EGFR expression is not limited to the basal layer, as it is in normal squamous epithelia.

Neg (not) Negative_regulation (limited) of Gene_expression (expression) of EGFR in basal layer associated with cholesteatoma

8) Confidence 0.06 Published 2008 Journal Clinical and Experimental Otorhinolaryngology Section Body Doc Link PMC2671742 Disease Relevance 0.85 Pain Relevance 0

General Comments

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