INT124955

Context Info Confidence 0.27 First Reported 2005 Last Reported 2005 Negated 1 Speculated 0 Reported most in Abstract Documents 3 Total Number 3 Disease Relevance 1.38 Pain Relevance 1.20

IgG2a (Mus musculus)

Pain Link Frequency Relevance Heat methotrexate 10 98.44 dexamethasone 10 98.34 Arthritis 2 89.60 cytokine 37 83.44 cINOD 2 75.52 Inflammation 8 68.56 rheumatoid arthritis 2 66.16 anesthesia 1 41.24

Disease Link Frequency Relevance Heat Sprains And Strains 42 98.28 Arthritis 8 89.60 INFLAMMATION 12 77.68 Rheumatoid Arthritis 2 66.16 Hypersensitivity 15 50.00 Anaphylaxis 6 5.00 Disease 4 5.00 Asthma 3 5.00 Immunization 2 5.00 Diabetes Mellitus 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

D-PA failed to influence anti-OVA IgG, IgG2a and IgG1 production as well as IFN-gamma and IL-10 secretion.

Neg (failed) Regulation (influence) of Gene_expression (production) of IgG2a

1) Confidence 0.27 Published 2005 Journal Int J Immunopathol Pharmacol Section Abstract Doc Link 15698518 Disease Relevance 0.58 Pain Relevance 0.58

Treatments with IND, DEX, MTX and AUR inhibited both Th1 and Th2 immune responses, although the inhibitory effects of these drugs on the antigen-specific IgG2a and IFN-gamma production appeared to be greater than those on IgG1 and IL-10 production.

Regulation (effects) of Gene_expression (production) of IgG2a associated with methotrexate and dexamethasone

2) Confidence 0.27 Published 2005 Journal Int J Immunopathol Pharmacol Section Abstract Doc Link 15698518 Disease Relevance 0.56 Pain Relevance 0.58

ELISA for detection of IgE, IgG1 and IgG2a anti-OVA antibodies

Regulation (ELISA) of Gene_expression (detection) of IgG2a

3) Confidence 0.25 Published 2005 Journal BMC Immunol Section Body Doc Link PMC1182367 Disease Relevance 0.24 Pain Relevance 0.04

General Comments

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