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Context Info
Confidence 0.34
First Reported 2005
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 3.67
Pain Relevance 1.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
IgG2a (Mus musculus)
Pain Link Frequency Relevance Heat
methotrexate 5 98.44 Very High Very High Very High
dexamethasone 5 98.34 Very High Very High Very High
spondylitis 9 94.96 High High
cytokine 77 88.96 High High
spinal inflammation 2 88.48 High High
Arthritis 1 77.28 Quite High
cINOD 1 75.52 Quite High
Inflammation 13 56.24 Quite High
rheumatoid arthritis 1 53.84 Quite High
isoflurane 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Immunization 86 99.08 Very High Very High Very High
Low Back Pain 11 94.96 High High
Alzheimer's Dementia 1 87.60 High High
Sprains And Strains 91 84.72 Quite High
Hypersensitivity 30 82.20 Quite High
Disease 8 80.64 Quite High
Asthma 7 79.84 Quite High
INFLAMMATION 15 77.68 Quite High
Arthritis 4 77.28 Quite High
Disease Susceptibility 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As previously reported (Noh et al., 2005), and reproduced in the present study, intraperitoneal injection of vitamin C markedly lowered the level of IgG1 isotype, without affecting the level of IgG2a.
Neg (without) Regulation (affecting) of IgG2a
1) Confidence 0.34 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998772 Disease Relevance 0 Pain Relevance 0.04
Treatments with IND, DEX, MTX and AUR inhibited both Th1 and Th2 immune responses, although the inhibitory effects of these drugs on the antigen-specific IgG2a and IFN-gamma production appeared to be greater than those on IgG1 and IL-10 production.
Regulation (effects) of IgG2a associated with methotrexate and dexamethasone
2) Confidence 0.27 Published 2005 Journal Int J Immunopathol Pharmacol Section Abstract Doc Link 15698518 Disease Relevance 0.55 Pain Relevance 0.58
We examined how polystyrene particles (PSP) affected the IgE and IgG2a responses against the model allergen ovalbumin (OVA), after subcutaneous injection into the footpad of BALB/cA, BALB/cJ, NIH and C3H/HeN mice, Further, ex vivo IL-4, IFN-?
Spec (examined) Regulation (responses) of IgG2a in PSP
3) Confidence 0.15 Published 2005 Journal BMC Immunol Section Abstract Doc Link PMC1182367 Disease Relevance 0.38 Pain Relevance 0.08
Similar to the responses in NIH mice, PSP had an adjuvant effect on both IgE and IgG2a responses in C3H/HeN mice, although the responses appeared weaker in C3H/HeN than in NIH and BALB/c mice.
Regulation (responses) of IgG2a in PSP
4) Confidence 0.15 Published 2005 Journal BMC Immunol Section Body Doc Link PMC1182367 Disease Relevance 0.33 Pain Relevance 0.06
Locus on chromosome 11 near the Stat3 and Stat5 genes controlled serum level of the Ig IgG2a isotype.
Regulation (controlled) of IgG2a
5) Confidence 0.15 Published 2005 Journal J. Immunol. Section Abstract Doc Link 16081819 Disease Relevance 1.26 Pain Relevance 0.45
IgG subtype profiling (Fig. 5) showed that i.n. immunization with subunit vaccine alone induced low IgG1, IgG2a, and IgG2b responses.
Regulation (responses) of IgG2a associated with immunization
6) Confidence 0.02 Published 2010 Journal AAPS J Section Body Doc Link PMC2844513 Disease Relevance 1.16 Pain Relevance 0

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