INT124956

Context Info Confidence 0.34 First Reported 2005 Last Reported 2010 Negated 1 Speculated 1 Reported most in Abstract Documents 5 Total Number 6 Disease Relevance 3.67 Pain Relevance 1.21

Anatomy Link Frequency PSP 2 IgG2a (Mus musculus)

Pain Link Frequency Relevance Heat methotrexate 5 98.44 dexamethasone 5 98.34 spondylitis 9 94.96 cytokine 77 88.96 spinal inflammation 2 88.48 Arthritis 1 77.28 cINOD 1 75.52 Inflammation 13 56.24 rheumatoid arthritis 1 53.84 isoflurane 6 5.00

Disease Link Frequency Relevance Heat Immunization 86 99.08 Low Back Pain 11 94.96 Alzheimer's Dementia 1 87.60 Sprains And Strains 91 84.72 Hypersensitivity 30 82.20 Disease 8 80.64 Asthma 7 79.84 INFLAMMATION 15 77.68 Arthritis 4 77.28 Disease Susceptibility 1 75.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

As previously reported (Noh et al., 2005), and reproduced in the present study, intraperitoneal injection of vitamin C markedly lowered the level of IgG1 isotype, without affecting the level of IgG2a.

Neg (without) Regulation (affecting) of IgG2a

1) Confidence 0.34 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998772 Disease Relevance 0 Pain Relevance 0.04

Treatments with IND, DEX, MTX and AUR inhibited both Th1 and Th2 immune responses, although the inhibitory effects of these drugs on the antigen-specific IgG2a and IFN-gamma production appeared to be greater than those on IgG1 and IL-10 production.

Regulation (effects) of IgG2a associated with methotrexate and dexamethasone

2) Confidence 0.27 Published 2005 Journal Int J Immunopathol Pharmacol Section Abstract Doc Link 15698518 Disease Relevance 0.55 Pain Relevance 0.58

We examined how polystyrene particles (PSP) affected the IgE and IgG2a responses against the model allergen ovalbumin (OVA), after subcutaneous injection into the footpad of BALB/cA, BALB/cJ, NIH and C3H/HeN mice, Further, ex vivo IL-4, IFN-?

Spec (examined) Regulation (responses) of IgG2a in PSP

3) Confidence 0.15 Published 2005 Journal BMC Immunol Section Abstract Doc Link PMC1182367 Disease Relevance 0.38 Pain Relevance 0.08

Similar to the responses in NIH mice, PSP had an adjuvant effect on both IgE and IgG2a responses in C3H/HeN mice, although the responses appeared weaker in C3H/HeN than in NIH and BALB/c mice.

Regulation (responses) of IgG2a in PSP

4) Confidence 0.15 Published 2005 Journal BMC Immunol Section Body Doc Link PMC1182367 Disease Relevance 0.33 Pain Relevance 0.06

Locus on chromosome 11 near the Stat3 and Stat5 genes controlled serum level of the Ig IgG2a isotype.

Regulation (controlled) of IgG2a

5) Confidence 0.15 Published 2005 Journal J. Immunol. Section Abstract Doc Link 16081819 Disease Relevance 1.26 Pain Relevance 0.45

IgG subtype profiling (Fig. 5) showed that i.n. immunization with subunit vaccine alone induced low IgG1, IgG2a, and IgG2b responses.

Regulation (responses) of IgG2a associated with immunization

6) Confidence 0.02 Published 2010 Journal AAPS J Section Body Doc Link PMC2844513 Disease Relevance 1.16 Pain Relevance 0

General Comments

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