INT124960

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Context Info
Confidence 0.52
First Reported 2005
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 9
Total Number 11
Disease Relevance 8.39
Pain Relevance 5.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Scn11a) plasma membrane (Scn11a) transmembrane transport (Scn11a)
Anatomy Link Frequency
sciatic nerve 1
nerve 1
neurons 1
Scn11a (Mus musculus)
Pain Link Frequency Relevance Heat
Sciatic nerve 16 100.00 Very High Very High Very High
calcitonin gene related peptide 11 100.00 Very High Very High Very High
Neuropeptide 12 99.40 Very High Very High Very High
Pain 531 99.22 Very High Very High Very High
dorsal root ganglion 148 99.04 Very High Very High Very High
antagonist 3 98.72 Very High Very High Very High
trigeminal ganglion 75 98.46 Very High Very High Very High
Eae 210 97.16 Very High Very High Very High
Spontaneous pain 48 96.32 Very High Very High Very High
analgesia 1 95.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nervous System Injury 152 99.56 Very High Very High Very High
Pain 571 99.22 Very High Very High Very High
Ganglion Cysts 257 99.04 Very High Very High Very High
Sprains And Strains 1024 98.68 Very High Very High Very High
Neuroma 48 97.28 Very High Very High Very High
Appetite Loss 2 96.36 Very High Very High Very High
Fever 1 95.36 Very High Very High Very High
Targeted Disruption 52 93.48 High High
Neuropathic Pain 496 88.84 High High
INFLAMMATION 19 79.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Regulation of the Na+ channel ?
Regulation (Regulation) of Na
1) Confidence 0.52 Published 2009 Journal Mol Pain Section Body Doc Link PMC2649910 Disease Relevance 0.72 Pain Relevance 0.42
On the basis of these results one of the up-regulated genes (Gal, which codes for the neuropeptide galanin) and one of the down-regulated genes (Scn11a) were chosen as marker genes for "step 2" TaqMan analysis.
Regulation (regulated) of Scn11a associated with neuropeptide
2) Confidence 0.44 Published 2009 Journal Mol Pain Section Body Doc Link PMC2649910 Disease Relevance 0.37 Pain Relevance 0.19
Outlier values for Gal and Scn11a were also found in two AKR mice (one operated, one sham) and in one operated CBA mouse.
Regulation (values) of Scn11a
3) Confidence 0.44 Published 2009 Journal Mol Pain Section Body Doc Link PMC2649910 Disease Relevance 0.53 Pain Relevance 0.09
That is, the less the degree of down-regulation of Scn11a, the greater the degree of pain behavior.
Regulation (regulation) of Scn11a associated with pain
4) Confidence 0.44 Published 2009 Journal Mol Pain Section Body Doc Link PMC2649910 Disease Relevance 1.33 Pain Relevance 0.46
Seven of the eight are known to be significantly regulated in L5DRGs in rats following sciatic nerve transection (Gal, Pacap, Cchl2a, Sprr1a, C-Jun, Trpv1 and Scn11a) while one is not regulated (Mmpcp1; [2]).
Regulation (regulated) of Scn11a in sciatic nerve associated with sciatic nerve
5) Confidence 0.26 Published 2009 Journal Mol Pain Section Body Doc Link PMC2649910 Disease Relevance 0.42 Pain Relevance 0.27
Correlational analysis of genes already known to be related to pain provided evidence that in the case of Scn11a and Trpm8, differential regulation following nerve injury plays a role in phenotypic variability across strains.
Regulation (regulation) of Scn11a in nerve associated with pain, nervous system injury and sprains and strains
6) Confidence 0.26 Published 2009 Journal Mol Pain Section Body Doc Link PMC2649910 Disease Relevance 1.24 Pain Relevance 0.70
Correlational analysis based on in situ hybridization provided evidence that differential regulation of Scn11a and Trpm8 contributes to across-strain variability in pain phenotype.
Regulation (regulation) of Scn11a associated with pain and sprains and strains
7) Confidence 0.26 Published 2009 Journal Mol Pain Section Abstract Doc Link PMC2649910 Disease Relevance 1.13 Pain Relevance 0.75
Effect of NAN-190, a selective 5-HT(1A) receptor antagonist, on methamphetamine-induced locomotor activity, anorexia, analgesia, and hyperthermia was investigated in male mice.
Spec (investigated) Regulation (Effect) of NAN-190 associated with appetite loss, eae, antagonist, fever and analgesia
8) Confidence 0.23 Published 2005 Journal Regul. Toxicol. Pharmacol. Section Abstract Doc Link 15698535 Disease Relevance 0.25 Pain Relevance 0.31
Among these, regulation of the Na+ channel ?
Regulation (regulation) of Na
9) Confidence 0.23 Published 2009 Journal Mol Pain Section Abstract Doc Link PMC2649910 Disease Relevance 1.35 Pain Relevance 0.87
The TG of Brn3a-/- newborn mice exhibit marked reduction in Trpm8, Mrga1, Mrgd and Scn11a, while CGRP and SP are minimally affected.
Regulation (affected) of Scn11a associated with calcitonin gene related peptide and trigeminal ganglion
10) Confidence 0.09 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.46 Pain Relevance 0.93
To further examine the modulation of TTX-R Na(+) current by PGE(2), we recorded two components of TTX-R Na(+) current in isolation from small (<25 microm in diameter) DRG neurons using wild-type and Na(V)1.8 knock-out mice.
Spec (examine) Regulation (modulation) of Na in neurons associated with targeted disruption and dorsal root ganglion
11) Confidence 0.03 Published 2007 Journal J. Pharmacol. Sci. Section Abstract Doc Link 17220592 Disease Relevance 0.59 Pain Relevance 0.50

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