INT124974

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Context Info
Confidence 0.59
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 4.59
Pain Relevance 3.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Tnfrsf1b) cell death (Tnfrsf1b) nucleus (Tnfrsf1b)
Anatomy Link Frequency
neurons 2
HEL 1
Tnfrsf1b (Mus musculus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 44 99.76 Very High Very High Very High
Dorsal horn 32 99.64 Very High Very High Very High
Spinal cord 54 99.52 Very High Very High Very High
Hyperalgesia 6 99.24 Very High Very High Very High
Eae 11 97.36 Very High Very High Very High
Cancer pain 2 97.36 Very High Very High Very High
Thermal hyperalgesia 8 95.16 Very High Very High Very High
allodynia 6 94.16 High High
Arthritis 54 90.28 High High
Sciatic nerve 6 86.20 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 44 99.76 Very High Very High Very High
Wallerian Degeneration 2 99.68 Very High Very High Very High
Cancer 20 99.44 Very High Very High Very High
Hyperalgesia 14 99.24 Very High Very High Very High
Injury 11 97.36 Very High Very High Very High
Cancer Pain 2 97.36 Very High Very High Very High
Targeted Disruption 4 96.96 Very High Very High Very High
Neuropathic Pain 17 94.16 High High
Arthritis 90 90.28 High High
Pressure And Volume Under Development 10 84.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data indicate that endoneurial TNFR1 and TNFR2 proteins are differentially regulated during Wallerian degeneration.
Regulation (regulated) of TNFR2 associated with wallerian degeneration
1) Confidence 0.59 Published 2005 Journal Exp. Neurol. Section Abstract Doc Link 15698630 Disease Relevance 1.11 Pain Relevance 0.44
In contrast, TRPV1 receptor up-regulation in DRG neurons is dependent on TNFR2 receptors in tumor-bearing mice [4].
Regulation (dependent) of TNFR2 in neurons associated with dorsal root ganglion and cancer
2) Confidence 0.26 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2936303 Disease Relevance 1.44 Pain Relevance 1.10
A role for TNFR2 receptors in heat hyperalgesia has been implicated in a model of cancer pain where TRPV1 protein up-regulation in DRG neurons is attenuated in TNFR2 knock-out mice [4].
Regulation (role) of TNFR2 in neurons associated with targeted disruption, dorsal root ganglion, hyperalgesia and cancer pain
3) Confidence 0.26 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2936303 Disease Relevance 1.52 Pain Relevance 1.38
When control mTNFRII-Fc (lacking the scFv, and thus with a molecular weight ?
Regulation (control) of mTNFRII-Fc
4) Confidence 0.06 Published 2010 Journal Arthritis and Rheumatism Section Body Doc Link PMC2905615 Disease Relevance 0.26 Pain Relevance 0.04
g of 1-11E/mTNFRII-Fc or control HEL/mTNFRII-Fc, as described previously (26).
Regulation (control) of mTNFRII-Fc in HEL
5) Confidence 0.06 Published 2010 Journal Arthritis and Rheumatism Section Body Doc Link PMC2905615 Disease Relevance 0.26 Pain Relevance 0.05

General Comments

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