INT124975

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Context Info
Confidence 0.41
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 3.57
Pain Relevance 0.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Tnfrsf22) plasma membrane (Tnfrsf22) cellular_component (Tnfrsf22)
Anatomy Link Frequency
sciatic nerves 1
Tnfrsf22 (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 108 98.84 Very High Very High Very High
Neuropathic pain 1 98.48 Very High Very High Very High
Eae 5 97.04 Very High Very High Very High
Sciatic nerve 2 95.32 Very High Very High Very High
cytokine 62 93.16 High High
Inflammation 72 92.80 High High
Etanercept 2 77.80 Quite High
Inflammatory response 19 68.32 Quite High
cINOD 5 64.76 Quite High
Glutamate 6 57.72 Quite High
Disease Link Frequency Relevance Heat
Hypothermia 55 99.60 Very High Very High Very High
Arthritis 112 98.84 Very High Very High Very High
Neuropathic Pain 1 98.48 Very High Very High Very High
Brain Injury 5 97.28 Very High Very High Very High
Injury 22 96.20 Very High Very High Very High
Necrosis 8 93.76 High High
Cancer 5 93.40 High High
INFLAMMATION 102 92.80 High High
Targeted Disruption 13 92.72 High High
Hyperplasia 4 82.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here, we investigated local protein levels of the two known TNF receptors, TNF receptor 1 and 2 (TNFR1, TNFR2), on days 0, 1, 3, 7, 14, and 28 after unilateral crush or chronic constriction injury (CCI) of mouse sciatic nerves using enzyme-linked immunoassay.
Spec (investigated) Gene_expression (levels) of TNF receptor 1 and 2 in sciatic nerves associated with eae, injury and sciatic nerve
1) Confidence 0.41 Published 2005 Journal Exp. Neurol. Section Abstract Doc Link 15698630 Disease Relevance 1.10 Pain Relevance 0.48
It would be interesting to know if hypothermia also decreases the expression of TNF receptor 2.
Gene_expression (expression) of TNF receptor 2 associated with hypothermia
2) Confidence 0.11 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2988764 Disease Relevance 1.52 Pain Relevance 0.15
Other studies using electrotransfer or intramuscular injection of a plasmid with a doxycycline-regulated promoter to control expression of a dimeric soluble TNF receptor II molecule saw a therapeutic effect on CIA only when doxycycline was administered [73, 74].
Gene_expression (expression) of TNF receptor II molecule associated with arthritis
3) Confidence 0.03 Published 2008 Journal Mod Rheumatol Section Body Doc Link PMC2275302 Disease Relevance 0.94 Pain Relevance 0.34

General Comments

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