INT124976

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Context Info
Confidence 0.67
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 16
Disease Relevance 14.92
Pain Relevance 5.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Tnfrsf1b) cell death (Tnfrsf1b) nucleus (Tnfrsf1b)
Anatomy Link Frequency
neuronal 1
nociceptor 1
Tnfrsf1b (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 14 100.00 Very High Very High Very High
Eae 15 99.92 Very High Very High Very High
nociceptor 5 99.28 Very High Very High Very High
rheumatoid arthritis 187 99.00 Very High Very High Very High
Hyperalgesia 6 98.98 Very High Very High Very High
Inflammation 216 98.44 Very High Very High Very High
chemokine 44 97.24 Very High Very High Very High
cytokine 174 96.64 Very High Very High Very High
Multiple sclerosis 171 96.36 Very High Very High Very High
Sciatic nerve 6 92.04 High High
Disease Link Frequency Relevance Heat
Systemic Lupus Erythematosus 130 100.00 Very High Very High Very High
Death 60 100.00 Very High Very High Very High
Cancer 56 100.00 Very High Very High Very High
Necrosis 45 100.00 Very High Very High Very High
Injury 53 99.92 Very High Very High Very High
Toxicity 6 99.76 Very High Very High Very High
Rheumatoid Arthritis 189 99.00 Very High Very High Very High
Hyperalgesia 6 98.98 Very High Very High Very High
Weight Gain 21 98.72 Very High Very High Very High
Apoptosis 123 98.46 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Unlike TNFR1, TNFR2 was markedly upregulated already on day 1 after crush or CCI.
Positive_regulation (upregulated) of TNFR2 associated with eae
1) Confidence 0.67 Published 2005 Journal Exp. Neurol. Section Abstract Doc Link 15698630 Disease Relevance 1.09 Pain Relevance 0.48
TNFR2 increased by 7-fold on days 3 and 7, and remained elevated at a lower level until day 28 after both CCI and crush injury.
Positive_regulation (elevated) of TNFR2 associated with eae and injury
2) Confidence 0.45 Published 2005 Journal Exp. Neurol. Section Abstract Doc Link 15698630 Disease Relevance 1.17 Pain Relevance 0.47
TNFR2 increased by 7-fold on days 3 and 7, and remained elevated at a lower level until day 28 after both CCI and crush injury.
Positive_regulation (increased) of TNFR2 associated with eae and injury
3) Confidence 0.45 Published 2005 Journal Exp. Neurol. Section Abstract Doc Link 15698630 Disease Relevance 1.17 Pain Relevance 0.47
We propose endogenous TNFalpha as a key player in cancer-related heat hyperalgesia and nociceptor sensitization that generates TRPV1 upregulation and sensitization via TNFR2.
Positive_regulation (upregulation) of TNFR2 in nociceptor associated with hyperalgesia, cancer and nociceptor
4) Confidence 0.44 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18463260 Disease Relevance 1.62 Pain Relevance 0.95
Serum levels of sTNFRII were elevated up to 12 years prior to RA symptoms and were positively associated with incident RA.
Positive_regulation (elevated) of sTNFRII associated with rheumatoid arthritis
5) Confidence 0.37 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2768824 Disease Relevance 1.65 Pain Relevance 0.60
TNFR2 does not contain a DD, and thus, unlike signaling through TNFR1, TNFR2 activation does not directly lead to caspase activation.
Positive_regulation (activation) of TNFR2
6) Confidence 0.35 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2577641 Disease Relevance 0.16 Pain Relevance 0.11
Given the growing evidence that TNFR2 may antagonize TNFR1 signaling, a second strategy, which may bestow beneficial effects and allow protection of neuronal populations highly sensitive to solTNF/TNFR1-mediated toxicity, may be to increase TNFR2 expression levels through gene therapy.
Positive_regulation (increase) of TNFR2 in neuronal associated with toxicity
7) Confidence 0.35 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2577641 Disease Relevance 0.35 Pain Relevance 0.25
Overall, TNFR2 activation is believed to initiate primarily pro-inflammatory and pro-survival signaling.


Positive_regulation (activation) of TNFR2 associated with inflammation
8) Confidence 0.33 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2577641 Disease Relevance 0.17 Pain Relevance 0.08
[43] and an increase in serum TNFRs, of which TNFR2 may play a protective role for myelin [44].
Positive_regulation (increase) of TNFR2
9) Confidence 0.29 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1112612 Disease Relevance 0.86 Pain Relevance 0.52
stimulation may be involved not only in the apoptotic signal pathway mediated by TNFR1, but may also play a regenerative role via activation of TNFR2 [46].
Positive_regulation (activation) of TNFR2 associated with apoptosis
10) Confidence 0.29 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1112612 Disease Relevance 0.46 Pain Relevance 0.14
Among the genes upregulated in SLE were TNF/death receptor genes such as TNFRII, and the death receptor ligand TNF-related apoptosis-inducing ligand (TRAIL) (TNFSF10).
Positive_regulation (upregulated) of TNFRII associated with apoptosis, systemic lupus erythematosus and death
11) Confidence 0.28 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2768824 Disease Relevance 1.93 Pain Relevance 0.35
We use the model to analyze the effects of anti-TNF therapy by simulating anti-TNF antibody and TNFR2Fc.
Positive_regulation (simulating) of TNFR2Fc
12) Confidence 0.23 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC2041971 Disease Relevance 0.76 Pain Relevance 0.06
The pharmacodynamic differences between these two agents include increased dissociation rate of TNF from TNFR2Fc compared with antibody [47].
Positive_regulation (increased) of TNFR2Fc
13) Confidence 0.23 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC2041971 Disease Relevance 0.54 Pain Relevance 0.11
A combination of anti-E/L-selectin resulted in elevations in IL-6, IL-8, and Tumour Necrosis Factor Receptor-1 (TNFR-1) when used in a septic model of heat killed E. coli followed by live E. coli [18].
Positive_regulation (elevations) of TNFR-1 associated with necrosis and cancer
14) Confidence 0.02 Published 2005 Journal Crit Care Section Body Doc Link PMC1414036 Disease Relevance 1.17 Pain Relevance 0.13
Elevated IL-6, CRP, TNFR-p55 and TNFR-p75 were associated with decreased survival (Yeh et al 2000b, 2001, 2004).
Positive_regulation (Elevated) of TNFR-p75
15) Confidence 0.02 Published 2006 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676640 Disease Relevance 0.76 Pain Relevance 0.20
As for the mechanism of its action, soluble tumor necrosis factor receptor 1 (sTNFR), sTNFR2 and interleukin 1 receptor antagonist were elevated soon after cytapheresis and those levels 2 h after the cytapheresis procedure were higher than before the procedure in some cases.
Positive_regulation (elevated) of sTNFR2 associated with necrosis, cancer and antagonist
16) Confidence 0.00 Published 2006 Journal Ther Apher Dial Section Abstract Doc Link 17096695 Disease Relevance 1.07 Pain Relevance 0.21

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