INT124996

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Context Info
Confidence 0.23
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 7
Disease Relevance 1.54
Pain Relevance 1.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Gpx3) oxidoreductase activity (Gpx3) extracellular region (Gpx3)
Anatomy Link Frequency
spines 1
striatum 1
extracellular matrix 1
synapse 1
microglia 1
Gpx3 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 7 100.00 Very High Very High Very High
Dopamine 5 99.56 Very High Very High Very High
Serotonin 3 98.96 Very High Very High Very High
Hippocampus 8 98.24 Very High Very High Very High
Nucleus accumbens 4 97.08 Very High Very High Very High
behavioral therapy 1 91.08 High High
Opioid 1 89.40 High High
imagery 81 82.88 Quite High
Glutamate receptor 1 67.52 Quite High
antagonist 1 66.76 Quite High
Disease Link Frequency Relevance Heat
Sprains And Strains 4 99.56 Very High Very High Very High
Neurological Disease 1 97.28 Very High Very High Very High
Hyperhomocysteinemia 2 95.96 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 1 93.16 High High
Fracture Healing 64 92.92 High High
Neuroblastoma 8 80.36 Quite High
Targeted Disruption 5 72.48 Quite High
Brain Injury 10 66.48 Quite High
Alzheimer's Dementia 8 50.72 Quite High
Disease 27 38.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, using the "in vivo" microdialysis technique in these strains, we investigated the effect of morphine administration on the extracellular levels of dopamine (DA), serotonin (5-HT), and their metabolites in the nucleus accumbens and dorsal striatum--areas thought to be involved in morphine-induced locomotor hyperactivity.
Spec (investigated) Regulation (effect) of extracellular in striatum associated with nucleus accumbens, dopamine, attention deficit hyperactivity disorder, sprains and strains, serotonin and morphine
1) Confidence 0.23 Published 2005 Journal Synapse Section Abstract Doc Link 15700287 Disease Relevance 0.37 Pain Relevance 1.08
The genes were grouped by the authors into a number of functional classes, which overlap to a large extent with the classes identified in the present investigation, including extracellular matrix proteins, ribosomal proteins, resorption/remodeling, transcriptional regulation and signal transduction.
Regulation (regulation) of extracellular in extracellular matrix
2) Confidence 0.07 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1578570 Disease Relevance 0.42 Pain Relevance 0
Taken together, our findings from immunocytochemical EM and SSEM with 3-D reconstructions indicate that microglia are uniquely positioned to play several physiological roles at synapses: through cell–cell communication with perisynaptic astrocytic processes, dendritic spines, and axon terminals simultaneously, as well as through the regulation of the extracellular environment intervening between them.


Regulation (regulation) of extracellular in microglia
3) Confidence 0.01 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2970556 Disease Relevance 0.07 Pain Relevance 0.04
Here we show that different modalities of microglial behavior are subtly altered by sensory experience, including regulation of extracellular spaces, apposition and phagocytosis of synaptic elements, dynamic interaction with subsets of dendritic spines, and motility of microglial processes.
Regulation (regulation) of extracellular in spines
4) Confidence 0.01 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2970556 Disease Relevance 0 Pain Relevance 0
In addition to revealing the three-dimensional (3-D) geometry of cell–cell contacts between microglia and all synapse-associated elements (dendritic spines, axon terminals, perisynaptic astrocytic processes, and synaptic clefts), our observations uncovered new modes of microglia–synapse interaction under non-pathological conditions, particularly the regulation of the perisynaptic extracellular space and the phagocytosis of synaptic elements.
Regulation (regulation) of extracellular in synapse
5) Confidence 0.01 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2970556 Disease Relevance 0 Pain Relevance 0
Regulation of extracellular signal-regulated kinase by homocysteine in hippocampus.
Regulation (Regulation) of extracellular in hippocampus associated with hippocampus
6) Confidence 0.00 Published 2005 Journal Neuroscience Section Title Doc Link 15916860 Disease Relevance 0.27 Pain Relevance 0.22
The effect of latrepirdine on extracellular levels of A?
Regulation (effect) of extracellular
7) Confidence 0.00 Published 2009 Journal Mol Neurodegener Section Body Doc Link PMC2806870 Disease Relevance 0.42 Pain Relevance 0

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