INT125005

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Context Info
Confidence 0.42
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 5.79
Pain Relevance 4.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (SLPI) enzyme binding (SLPI)
Anatomy Link Frequency
leukocyte 2
Hippocampus 1
SLPI (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 54 100.00 Very High Very High Very High
Pain 311 99.76 Very High Very High Very High
Hippocampus 2 97.26 Very High Very High Very High
Inflammation 33 94.36 High High
spastic colon 1 91.64 High High
Lasting pain 68 90.56 High High
Crohn's disease 20 82.64 Quite High
metalloproteinase 58 75.68 Quite High
Fibrositis 20 66.92 Quite High
backache 8 65.40 Quite High
Disease Link Frequency Relevance Heat
Frailty 51 100.00 Very High Very High Very High
Pain 367 99.76 Very High Very High Very High
Mental Disorders 20 99.20 Very High Very High Very High
Osteoporosis 3 99.18 Very High Very High Very High
INFLAMMATION 34 94.36 High High
Functional Bowel Disorder 1 91.64 High High
Disease 39 82.00 Quite High
Anxiety 28 76.00 Quite High
Metaplasia 3 75.48 Quite High
Osteoarthritis 7 75.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Serum alkaline phosphatase (ALP) (bone formation marker) decreased from a median of 731.0 U/l (range 438-998 U/l) to 183 U/l (range 95-286 U/l) (p <0.001), implying a significant reduction in bone turnover and resorption and increase in bone mineralization.
Negative_regulation (decreased) of ALP
1) Confidence 0.42 Published 2010 Journal J. Pediatr. Endocrinol. Metab. Section Body Doc Link 20432809 Disease Relevance 0.07 Pain Relevance 0
ES between 0.50 and 0.79 were recorded for the pain NRS, SF-36 role physical, SF-36 bodily pain, SF-36 social functioning, SF-36 mental health, SF-36 mental component summary (MCS), MPI interference with pain, MPI life control, and MPI negative mood.
Negative_regulation (interference) of MPI associated with mental disorders and pain
2) Confidence 0.31 Published 2008 Journal BMC Med Res Methodol Section Body Doc Link PMC2386498 Disease Relevance 1.21 Pain Relevance 0.87
In the function and the physical role interference comparisons, only the comparison of MPI interference with SF-36 social functioning showed moderate correlations (up 0.50).
Negative_regulation (interference) of MPI
3) Confidence 0.31 Published 2008 Journal BMC Med Res Methodol Section Body Doc Link PMC2386498 Disease Relevance 0.88 Pain Relevance 0.81
The comparisons MPI interference with pain versus SF-36 role physical, 0.42 versus 0.03, and MPI activity versus SF-36 physical functioning, 0.22 versus 0.27, were not statistically tested since these domains showed a small overlap and correlation in the regression analysis whereas the other three (pain, interference, mood) largely overlapped – our data reproduced these overlap findings.
Negative_regulation (interference) of MPI associated with pain
4) Confidence 0.31 Published 2008 Journal BMC Med Res Methodol Section Body Doc Link PMC2386498 Disease Relevance 1.15 Pain Relevance 1.05
The SRMs between the MPI and the SF-36 were not significantly different within the domains (t-test): MPI pain severity versus SF-36 bodily pain, 0.41 versus 0.44; MPI interference with pain versus SF-36 social functioning, 0.42 versus 0.25; MPI negative mood versus SF-36 mental health, 0.22 versus 0.09.
Negative_regulation (interference) of MPI associated with mental disorders and pain
5) Confidence 0.31 Published 2008 Journal BMC Med Res Methodol Section Body Doc Link PMC2386498 Disease Relevance 1.23 Pain Relevance 1.11
-defensin, LL37 and secreted leukocyte protease inhibitor.
Negative_regulation (inhibitor) of leukocyte protease in leukocyte
6) Confidence 0.30 Published 2010 Journal International Journal of Inflammation Section Body Doc Link PMC2992817 Disease Relevance 0.68 Pain Relevance 0.32
We show similar upregulation of two further anti-angiogenic protease inhibitors in OA, TIMP-3 and SLPI, with comparable expression patterns to TIMP-1.
Negative_regulation (inhibitors) of SLPI associated with osteoarthritis
7) Confidence 0.26 Published 2010 Journal Osteoarthritis and Cartilage Section Body Doc Link PMC2877870 Disease Relevance 0.40 Pain Relevance 0.13
The same research group has reported pronase E-derived hydrolysate peptide of 1821 Da from a sea horse, Hippocampus kuda Bleeler.This peptide has been checked for its induction of differentiation of osteoblastic MG-63 and chondrocytic SW-1353 cells by measuring ALP activity, mineralization, and collagen synthesis.
Negative_regulation (measuring) of ALP in Hippocampus associated with osteoporosis and hippocampus
8) Confidence 0.04 Published 2010 Journal Biochemistry Research International Section Body Doc Link PMC3004377 Disease Relevance 0.17 Pain Relevance 0.15
RESULTS: The antrum had a median secretory leukocyte protease inhibitor of 0.93 and HBD1 of 0.42, compared with 0.13 (P = 0.001) and 0.08 units (P = 0.002) respectively in the gastric body.
Negative_regulation (inhibitor) of leukocyte protease in leukocyte
9) Confidence 0.03 Published 2005 Journal Dig Liver Dis Section Body Doc Link 15702860 Disease Relevance 0 Pain Relevance 0

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