INT12501

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Context Info
Confidence 0.58
First Reported 1981
Last Reported 2010
Negated 2
Speculated 8
Reported most in Abstract
Documents 166
Total Number 174
Disease Relevance 36.94
Pain Relevance 118.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Adarb1) mRNA processing (Adarb1) nucleolus (Adarb1)
RNA binding (Adarb1) nucleus (Adarb1) intracellular (Adarb1)
Anatomy Link Frequency
spinal 7
spinal cord 5
brain 5
intestine 3
synapses 3
Adarb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 647 100.00 Very High Very High Very High
antagonist 632 100.00 Very High Very High Very High
Pain 387 100.00 Very High Very High Very High
Glutamate 323 100.00 Very High Very High Very High
Spinal cord 305 100.00 Very High Very High Very High
agonist 297 100.00 Very High Very High Very High
Dopamine 258 100.00 Very High Very High Very High
gABA 165 100.00 Very High Very High Very High
Opioid 134 100.00 Very High Very High Very High
Glutamate receptor 125 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 356 100.00 Very High Very High Very High
Hyperalgesia 73 100.00 Very High Very High Very High
Fever 15 99.92 Very High Very High Very High
Nociception 227 99.78 Very High Very High Very High
Heart Rate Under Development 523 99.68 Very High Very High Very High
Nervous System Injury 10 99.68 Very High Very High Very High
Hypersensitivity 19 99.64 Very High Very High Very High
Urological Neuroanatomy 18 99.58 Very High Very High Very High
Diabetes Mellitus 10 99.54 Very High Very High Very High
Tics 6 99.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Taurine at 0.3 mM activated glycine receptors, whereas at 3 mM activated both glycine and gamma-aminobutyric acid A receptors.
Positive_regulation (activated) of receptors
1) Confidence 0.58 Published 2008 Journal Neuroreport Section Abstract Doc Link 18303577 Disease Relevance 0.08 Pain Relevance 0.37
Taurine at 0.3 mM activated glycine receptors, whereas at 3 mM activated both glycine and gamma-aminobutyric acid A receptors.
Positive_regulation (activated) of receptors
2) Confidence 0.58 Published 2008 Journal Neuroreport Section Abstract Doc Link 18303577 Disease Relevance 0.08 Pain Relevance 0.38
However in the amygdala and in the thalamus the number of kappa receptors was increased in old animals.
Positive_regulation (increased) of receptors in amygdala associated with thalamus and amygdala
3) Confidence 0.48 Published 1989 Journal Life Sci. Section Abstract Doc Link 2557515 Disease Relevance 0.15 Pain Relevance 0.62
Since activation of either supraspinal or spinal alpha(2) adrenergic receptors can induce antinociception, and since improgan showed affinity for these receptors in vitro, the effects of the alpha(2) antagonist yohimbine on improgan antinociception were presently studied in rats on the hot plate and tail flick tests.
Positive_regulation (activation) of receptors in tail associated with antinociception, antagonist and tail-flick
4) Confidence 0.46 Published 2001 Journal Brain Res. Section Abstract Doc Link 11743967 Disease Relevance 0 Pain Relevance 0.92
Thus, these experiments suggest that in addition to mu receptors a separate subpopulation of delta but not kappa or sigma receptors are involved with spinally mediated analgesia.
Positive_regulation (subpopulation) of receptors associated with analgesia
5) Confidence 0.43 Published 1982 Journal Brain Res. Section Abstract Doc Link 6127147 Disease Relevance 0.07 Pain Relevance 1.24
Taurine activates glycine and gamma-aminobutyric acid A receptors in rat substantia gelatinosa neurons.
Positive_regulation (activates) of receptors in substantia gelatinosa associated with substantia gelatinosa neuron
6) Confidence 0.39 Published 2008 Journal Neuroreport Section Title Doc Link 18303577 Disease Relevance 0.10 Pain Relevance 0.37
This hypothesis was tested here by determining whether nerve injury produces (a) a decrease in mu receptors in the lumbar spinal cord; (b) a decrease in the affinity of ligand-receptor interaction, (c) a decrease in the fraction of high-affinity state of the mu receptors and (d) a reduced ability of morphine to activate G-proteins via mu receptors.
Spec (whether) Positive_regulation (decrease) of receptors in spinal cord associated with nervous system injury, morphine and spinal cord
7) Confidence 0.39 Published 1998 Journal Brain Res. Section Abstract Doc Link 9622629 Disease Relevance 0.80 Pain Relevance 1.19
The results indicated that cutaneous pain of a chemical/inflammatory nature is highly sensitive to activation of kappa receptors of the spinal cord dorsal horn.
Positive_regulation (activation) of receptors in spinal cord dorsal horn associated with pain, inflammation, dorsal horn and spinal cord
8) Confidence 0.32 Published 1990 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2272367 Disease Relevance 0.43 Pain Relevance 1.13
The present data provide pharmacological evidence that agmatine blocks the hyperthermic effect of morphine by activating imidazoline receptors.
Positive_regulation (activating) of receptors associated with morphine
9) Confidence 0.31 Published 2007 Journal Brain Res. Section Abstract Doc Link 17376409 Disease Relevance 0.41 Pain Relevance 0.64
Morphine (4 mg/kg, s.c.) produced hyperthermia by activating mu opioid receptors.
Positive_regulation (activating) of receptors associated with mu opioid receptor, fever and morphine
10) Confidence 0.31 Published 2007 Journal Brain Res. Section Abstract Doc Link 17376409 Disease Relevance 0.44 Pain Relevance 0.63
Furthermore, naltrindole alone (or the association of this antagonist plus dermenkephalin) enhanced the outflow of substance P-like material (+ 170%) as expected from the blockade of a tonic inhibitory control due to the stimulation of delta receptors by endogenous opioids.
Positive_regulation (stimulation) of receptors in outflow associated with antagonist, endogenous opioid and substance p
11) Confidence 0.29 Published 1991 Journal Neuroscience Section Abstract Doc Link 1721687 Disease Relevance 0 Pain Relevance 0.94
The binding properties of the new agonist Tyr-D-Ser(OtBu)-Gly-Phe-Leu-Thr, DSTBULET, in rat brain tissue shows that insertion of a bulky t.butyl group into the sequence of DSLET leads to a conformationally-induced large increase in selectivity for delta opioid receptors (KI(delta)/KI(mu) = 0.012).
Positive_regulation (increase) of receptors in brain associated with agonist and delta opioid receptors
12) Confidence 0.27 Published 1986 Journal NIDA Res. Monogr. Section Abstract Doc Link 2828972 Disease Relevance 0 Pain Relevance 0.29
These results showed that activation of mu or delta receptors caused hyperalgesia, whereas activation of kappa receptors caused antinociception in the hot plate test in naked mole-rat.
Positive_regulation (activation) of receptors associated with antinociception and hyperalgesia
13) Confidence 0.23 Published 2006 Journal Brain Res. Bull. Section Abstract Doc Link 17113929 Disease Relevance 0.34 Pain Relevance 0.74
Stimulation of mu and delta opioid receptors induces hyperalgesia while stimulation of kappa receptors induces antinociception in the hot plate test in the naked mole-rat (Heterocephalus glaber).
Positive_regulation (stimulation) of receptors associated with antinociception, hyperalgesia, nociceptor and delta opioid receptors
14) Confidence 0.23 Published 2006 Journal Brain Res. Bull. Section Title Doc Link 17113929 Disease Relevance 0.30 Pain Relevance 0.93
Stimulation of mu and delta opioid receptors induces hyperalgesia while stimulation of kappa receptors induces antinociception in the hot plate test in the naked mole-rat (Heterocephalus glaber).
Positive_regulation (Stimulation) of receptors associated with antinociception, hyperalgesia, nociceptor and delta opioid receptors
15) Confidence 0.23 Published 2006 Journal Brain Res. Bull. Section Title Doc Link 17113929 Disease Relevance 0.29 Pain Relevance 0.92
In conclusion, morphine per se did not change CGRPLM release because this drug triggers opposite positive (through the stimulation of delta receptors) and negative (through the concomitant stimulation of both kappa and mu receptors) control mechanisms within the rat spinal cord.
Positive_regulation (stimulation) of receptors in spinal cord associated with spinal cord and morphine
16) Confidence 0.23 Published 1993 Journal Brain Res. Section Abstract Doc Link 8389648 Disease Relevance 0 Pain Relevance 0.64
Indeed, a significant decrease in the spinal release of CGRPLM release could be evoked by the combined addition of U 50488 H (10 microM) plus DAGO (10 microM) to the perfusing medium, indicating that the simultaneous stimulation of both kappa and mu receptors is required for this negative control to occur.
Positive_regulation (stimulation) of receptors in spinal
17) Confidence 0.23 Published 1993 Journal Brain Res. Section Abstract Doc Link 8389648 Disease Relevance 0 Pain Relevance 0.79
In the present study, the effect of treadmill running on c-Fos expression in the hippocampus and the involvement of opioid receptors were investigated via c-Fos immunohistochemistry.
Positive_regulation (involvement) of receptors in hippocampus associated with opioid receptor and hippocampus
18) Confidence 0.22 Published 2003 Journal Life Sci. Section Abstract Doc Link 14550853 Disease Relevance 0 Pain Relevance 0.40
Our results suggest the involvement of both the CNS and the ENS mu opioid receptors in mechanisms of the intestinal tolerance to and dependence upon morphine.
Positive_regulation (involvement) of receptors associated with addiction, tolerance, mu opioid receptor and morphine
19) Confidence 0.21 Published 2005 Journal Folia Med Cracov Section Abstract Doc Link 17037289 Disease Relevance 0.22 Pain Relevance 1.20
It is well known that activation of the mu- and kappa-opioid receptors results in hyperthermia and hypothermia, respectively, in Sprague-Dawley rats.
Positive_regulation (activation) of receptors associated with hypothermia, kappa opioid receptor and fever
20) Confidence 0.21 Published 2001 Journal Brain Res. Section Abstract Doc Link 11406123 Disease Relevance 0.41 Pain Relevance 0.87

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