INT12502

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Context Info
Confidence 0.53
First Reported 1981
Last Reported 2010
Negated 13
Speculated 4
Reported most in Abstract
Documents 50
Total Number 54
Disease Relevance 7.58
Pain Relevance 30.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Adarb1) mRNA processing (Adarb1) nucleolus (Adarb1)
RNA binding (Adarb1) nucleus (Adarb1) intracellular (Adarb1)
Anatomy Link Frequency
brain 12
lateral 2
dorsal root ganglion 2
plasma 1
peroneal nerves 1
Adarb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 113 100.00 Very High Very High Very High
antagonist 95 100.00 Very High Very High Very High
Dopamine 78 100.00 Very High Very High Very High
opiate 59 100.00 Very High Very High Very High
cocaine 56 100.00 Very High Very High Very High
agonist 54 100.00 Very High Very High Very High
Spinal cord 45 100.00 Very High Very High Very High
opioid receptor 37 100.00 Very High Very High Very High
Opioid 35 100.00 Very High Very High Very High
Cholecystokinin 32 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 9 100.00 Very High Very High Very High
Hyperalgesia 16 99.84 Very High Very High Very High
Nervous System Injury 41 99.70 Very High Very High Very High
Neuroblastoma 2 99.68 Very High Very High Very High
Nociception 36 99.16 Very High Very High Very High
Glioma 2 99.04 Very High Very High Very High
Pain 31 97.92 Very High Very High Very High
Depression 7 93.88 High High
Hypersensitivity 5 93.88 High High
INFLAMMATION 21 92.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings indicate that rat cortical sigma receptors are differentially regulated by pentazocine and haloperidol.
Regulation (regulated) of receptors associated with fortral
1) Confidence 0.53 Published 1991 Journal J. Neural Transm. Gen. Sect. Section Abstract Doc Link 1850284 Disease Relevance 0 Pain Relevance 0.26
Using K+ phosphate buffer with 25 nM spiperone, [3H]YM-09151-2 binding showed a high affinity for sigma receptors but no affinity for D2 dopamine or 5-HT1A receptors in rat brain.
Neg (no) Regulation (affinity) of receptors in brain associated with dopamine
2) Confidence 0.38 Published 1996 Journal Neuroreport Section Abstract Doc Link 8804051 Disease Relevance 0 Pain Relevance 0.12
There was no change in delta or kappa receptors in the accumbens, a finding which indicates that the loss of mu opioid receptors was specific.
Neg (no) Regulation (change) of receptors associated with mu opioid receptor
3) Confidence 0.23 Published 1989 Journal Brain Res. Section Abstract Doc Link 2558779 Disease Relevance 0 Pain Relevance 0.44
Rat cortical sigma receptors differentially regulated by pentazocine and haloperidol.
Regulation (regulated) of receptors associated with fortral
4) Confidence 0.23 Published 1991 Journal J. Neural Transm. Gen. Sect. Section Title Doc Link 1850284 Disease Relevance 0 Pain Relevance 0.37
The enantiomer of (-)-1, (1R,2R)-trans-2-isothiocyanato-N-methyl-N-[2- (1-pyrrolidinyl)cyclohexyl]benzeneacetamide [(+)-1], failed to affect kappa receptors labeled by [3H]-U69,593 under the same conditions as for (-)-1. (1S,2S)-trans-3-Isothiocyanato-N-methyl-N-[2- (1-pyrrolidinyl)cyclohexyl]benzeneacetamide [(-)-2] inhibited to 49.6 +/- 5.1% of the control, in a wash-resistant manner, kappa receptors labeled by [3H]-U69,593.
Neg (failed) Regulation (affect) of receptors
5) Confidence 0.22 Published 1990 Journal J. Med. Chem. Section Abstract Doc Link 2157008 Disease Relevance 0 Pain Relevance 0.04
The effects of a potent and specific antagonist of 5-HT3 receptors, ICS 205-930, on the dopamine (DA)-releasing properties of morphine (1.0 mg/kg s.c.), nicotine (0.6 mg/kg s.c.), ethanol (1.0 g/kg i.p.) and amphetamine (0.25 and 1.0 mg/kg s.c.) were studied in rats.
Regulation (effects) of receptors associated with dopamine, nicotine, antagonist and morphine
6) Confidence 0.18 Published 1989 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2767122 Disease Relevance 0 Pain Relevance 0.69
Most investigators have studied the involvement of N-methyl-D-aspartate (NMDA) EAA receptors in hyperalgesia and nociception; less is known about the importance of non-NMDA EAA receptors in animal models of persistent pain.
Regulation (involvement) of receptors associated with pain, nociception, hyperalgesia and lasting pain
7) Confidence 0.09 Published 1998 Journal Pain Section Abstract Doc Link 9520236 Disease Relevance 1.04 Pain Relevance 1.15
Chronic opiate agonist treatment (24 h) of the cultured cells with either 10 microM U50488 (a selective kappa agonist), or 1 microM etorphine (a nonselective opiate agonist), did not change the number of kappa receptors and their binding affinity to [3H]diprenorphine.
Neg (not) Regulation (change) of receptors associated with agonist, opiate and immobilon
8) Confidence 0.09 Published 1990 Journal Brain Res. Section Abstract Doc Link 2165432 Disease Relevance 0.21 Pain Relevance 1.30
Previous and present results indicate opposite roles for alpha(2)-adrenergic receptors in the control of sodium and water intake according to their distribution in the rat brain.
Regulation (roles) of receptors in brain
9) Confidence 0.09 Published 2004 Journal Neuroscience Section Abstract Doc Link 15489025 Disease Relevance 0 Pain Relevance 0.04
Endogenous CART peptide regulates mu opioid and serotonin 5-HT(2A) receptors.
Regulation (regulates) of receptors associated with serotonin and opioid
10) Confidence 0.08 Published 2003 Journal Peptides Section Title Doc Link 12732339 Disease Relevance 0 Pain Relevance 0.49
CONCLUSIONS: Midazolam had much larger effects on extrasynaptic GABA type A receptors than the synaptic receptors, suggesting a role of the enhancement of GABAergic extrasynaptic currents in the midazolam-induced analgesia.
Regulation (effects) of receptors
11) Confidence 0.08 Published 2010 Journal Anesthesiology Section Body Doc Link 20613474 Disease Relevance 0 Pain Relevance 0
Decreases in paired-pulse facilitation could not be attributed to the reported effects of Pb2+ on N-methyl-D-aspartate (NMDA) receptors as MK-801 (1.0 mg/kg, s.c.) administration produced an opposing pattern of effects on paired-pulse measures.
Regulation (effects) of receptors
12) Confidence 0.08 Published 1996 Journal Brain Res. Section Abstract Doc Link 8930317 Disease Relevance 0.09 Pain Relevance 0.34
Cholinergic neurons which possess mu and delta receptors and/or which are regulated by neurons possessing these receptors, do not appear to have kappa receptors.
Regulation (regulated) of receptors in Cholinergic neurons
13) Confidence 0.05 Published 1981 Journal Neurosci. Lett. Section Abstract Doc Link 6262686 Disease Relevance 0 Pain Relevance 0.36
We have investigated the expression and regulation of kappa opiate receptors in rat spinal cord-dorsal root ganglion primary cocultures.
Spec (investigated) Regulation (regulation) of receptors in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion, opiate and spinal cord
14) Confidence 0.05 Published 1990 Journal Brain Res. Section Abstract Doc Link 2165432 Disease Relevance 0.17 Pain Relevance 0.66
Characterization of kappa opiate receptors in rat spinal cord-dorsal root ganglion cocultures and their regulation by chronic opiate treatment.
Regulation (regulation) of receptors in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion, opiate, immobilon and spinal cord
15) Confidence 0.05 Published 1990 Journal Brain Res. Section Title Doc Link 2165432 Disease Relevance 0.19 Pain Relevance 1.14
At a concentration as high as 300 microM (which is sufficient to block by 100% and 70% the activity of alpha7 and alpha4beta2 nAChRs, respectively), naltrexone had no effect on kainate and AMPA receptors, blocked by no more than 20% the activity of NMDA and glycine receptors, and reduced by 35% the activity of GABA(A) receptors.
Neg (no) Regulation (effect) of receptors associated with gaba
16) Confidence 0.05 Published 2000 Journal Neuropharmacology Section Abstract Doc Link 11044744 Disease Relevance 0.15 Pain Relevance 0.41
At a concentration as high as 300 microM (which is sufficient to block by 100% and 70% the activity of alpha7 and alpha4beta2 nAChRs, respectively), naltrexone had no effect on kainate and AMPA receptors, blocked by no more than 20% the activity of NMDA and glycine receptors, and reduced by 35% the activity of GABA(A) receptors.
Neg (no) Regulation (effect) of receptors associated with gaba
17) Confidence 0.05 Published 2000 Journal Neuropharmacology Section Abstract Doc Link 11044744 Disease Relevance 0.15 Pain Relevance 0.42
Naloxone treatment resulted in a strong up-regulation of neostriatal and pallidal mu opioid receptors that was not affected by the concurrent administration of haloperidol.
Neg (not) Regulation (affected) of receptors associated with mu opioid receptor and narcan
18) Confidence 0.04 Published 1999 Journal Neuroscience Section Abstract Doc Link 10426535 Disease Relevance 0 Pain Relevance 1.24
The amplitude of the variations of mu opioid receptor density and of preproenkephalin and preprodynorphin messenger RNA levels suggests that the regulation of neostriatal and pallidal micro opioid receptors is more susceptible to a direct opioid antagonism, while the biosynthesis of opioid peptides in the neostriatum is more dependent on the dopaminergic transmission.
Regulation (regulation) of receptors associated with mu opioid receptor, opioid receptor and opioid
19) Confidence 0.04 Published 1999 Journal Neuroscience Section Abstract Doc Link 10426535 Disease Relevance 0 Pain Relevance 1.07
Nevertheless, some of the effects of these three peptides endured well beyond their presence, and for BE included changes in the number of opiate receptors.
Regulation (changes) of receptors associated with opiate
20) Confidence 0.03 Published 1985 Journal Psychoneuroendocrinology Section Abstract Doc Link 2868478 Disease Relevance 0.12 Pain Relevance 0.42

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