INT125027

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Context Info
Confidence 0.50
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 15
Disease Relevance 7.73
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasmic membrane-bounded vesicle (Kdr) plasma membrane (Kdr) nucleus (Kdr)
cytoplasm (Kdr)
Anatomy Link Frequency
endothelial cells 2
retina 2
blood 1
pituitary 1
Kdr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Intracerebroventricular 1 92.72 High High
aspirin 2 86.36 High High
ischemia 20 85.84 High High
fibrosis 45 55.08 Quite High
nMDA receptor 9 50.00 Quite Low
cINOD 1 45.24 Quite Low
imagery 26 5.00 Very Low Very Low Very Low
anesthesia 16 5.00 Very Low Very Low Very Low
isoflurane 11 5.00 Very Low Very Low Very Low
cytokine 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 10 99.84 Very High Very High Very High
Hypoxia 166 99.58 Very High Very High Very High
Cancer 161 99.52 Very High Very High Very High
Stress 165 99.32 Very High Very High Very High
Diabetes Mellitus 337 99.24 Very High Very High Very High
Fibrosis 48 98.32 Very High Very High Very High
Pituitary Cancer 32 97.56 Very High Very High Very High
Myocardial Infarction 207 97.24 Very High Very High Very High
Ventricular Remodeling 30 96.92 Very High Very High Very High
Apoptosis 59 89.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activation of VEGFR-2 has been shown to be involved in the formation of complexes with various cytoplasmic proteins including adherence junction proteins [37,38].
Positive_regulation (Activation) of VEGFR-2
1) Confidence 0.50 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC519024 Disease Relevance 0.46 Pain Relevance 0
The Flk-1 positive area was increased after treatment with E2, but there was no significant difference in the intensity of the Flk-1 staining in the pituitary cells between the E2 group and the E2+G6-31 group (Fig. 5H and 5I).
Positive_regulation (increased) of Flk-1 in pituitary
2) Confidence 0.38 Published 2010 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2875861 Disease Relevance 0.06 Pain Relevance 0
It is evident that VEGFR-1, VEGFR-2 and neuropilin-1 levels increase following shear stress conditions.


Positive_regulation (increase) of VEGFR-2 associated with stress
3) Confidence 0.36 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC519024 Disease Relevance 0.47 Pain Relevance 0
Quantification of the above receptors showed a significant increase in VEGFR-1, VEGFR-2 and neuropilin-1 mRNA following shear stress.


Positive_regulation (increase) of VEGFR-2 associated with stress
4) Confidence 0.33 Published 2004 Journal Comp Hepatol Section Abstract Doc Link PMC519024 Disease Relevance 0.49 Pain Relevance 0
Immunohistochemistry showed that Flk-1 (VEGFR-2) was diffusely distributed in the anterior pituitary cells and vascular endothelial cells, and its staining was observed faintly in the control group (Fig. 5G).
Positive_regulation (distributed) of Flk-1 in endothelial cells
5) Confidence 0.26 Published 2010 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2875861 Disease Relevance 0 Pain Relevance 0
Increased expression levels of VEGF and Flk-1 have been reported in the peripheral blood of patients with pituitary tumors [30].
Positive_regulation (Increased) of Flk-1 in blood associated with pituitary cancer
6) Confidence 0.26 Published 2010 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2875861 Disease Relevance 0.57 Pain Relevance 0
Immunohistochemistry showed that Flk-1 (VEGFR-2) was diffusely distributed in the anterior pituitary cells and vascular endothelial cells, and its staining was observed faintly in the control group (Fig. 5G).
Positive_regulation (distributed) of VEGFR-2 in endothelial cells
7) Confidence 0.26 Published 2010 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2875861 Disease Relevance 0 Pain Relevance 0
The documented salicylate serum VEGF modulation is interesting also for presence of the flk-1 receptor in mammary tumour cells of our model.
Positive_regulation (presence) of flk-1 receptor associated with cancer
8) Confidence 0.19 Published 2005 Journal Int. J. Oncol. Section Abstract Doc Link 15703826 Disease Relevance 0.51 Pain Relevance 0.04
In contrast to the elevated levels of VEGF and FLK-1, FLT-1 expression was reduced by 37.5% in diabetic retinas (16.94 ± 0.76 vs. 27.09 ± 0.56 positive cells/mm, P < 0.0001) (Fig. 2C).
Positive_regulation (elevated) of FLK-1 in retinas associated with diabetes mellitus
9) Confidence 0.18 Published 2008 Journal Diabetes Section Body Doc Link PMC2836241 Disease Relevance 0.88 Pain Relevance 0
The therapy significantly reduced the ventricular remodeling as evidenced by the significant reduction in the collagenous fibrotic tissue and improvement in the myocardial functions in conjunction with significant increase in the levels of VEGF and its receptor Flk-1, Ang-1 and its receptor Tie-2, p-MK2, and antiapoptotic survivin.
Positive_regulation (increase) of Flk-1 associated with fibrosis and ventricular remodeling
10) Confidence 0.16 Published 2010 Journal Diabetes Section Body Doc Link PMC2797944 Disease Relevance 1.15 Pain Relevance 0.03
We also provide evidence demonstrating that shear stress imposed on LECs in vitro is accompanied by a significant increases in VEGFR-1, VEGFR-2 and neuropilin-1 mRNA levels.
Positive_regulation (increases) of VEGFR-2 associated with stress
11) Confidence 0.15 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC519024 Disease Relevance 0.42 Pain Relevance 0
Our results confirmed and extended previous observations that genes associated with hypoxia (specifically VEGF, Flk-1, and EPO) are indeed elevated following hypoxia in the retina.
Positive_regulation (elevated) of Flk-1 in retina associated with hypoxia
12) Confidence 0.12 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2635851 Disease Relevance 1.15 Pain Relevance 0.03
Recently, we have shown that ischemic preconditioning induces VEGF expression followed by Flk-1 activation, thereby activating an angiogenic signaling cascade by the activation of p38MAPK and MK2 leading to the activation of NF?
Positive_regulation (activation) of Flk-1
13) Confidence 0.11 Published 2010 Journal Diabetes Section Body Doc Link PMC2797944 Disease Relevance 0.35 Pain Relevance 0
Similarly, we observed a significant increase in the expression of VEGF (1.9-fold) and Flk-1 (5.3-fold) in the diabetic animals that received the therapy (DVAMI), 4 days after the combination gene transfer compared with the Ad.LacZ-treated diabetic MI (DLZMI) group (Fig. 4C and D).


Positive_regulation (increase) of Flk-1 associated with diabetes mellitus and myocardial infarction
14) Confidence 0.11 Published 2010 Journal Diabetes Section Body Doc Link PMC2797944 Disease Relevance 0.96 Pain Relevance 0
VEGF is one of the signaling molecules that binds to its receptors on cell membrane, VEGFR1 and VEGFR2, initiating signaling pathways through Akt activation.
Positive_regulation (activation) of VEGFR2
15) Confidence 0.01 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3020671 Disease Relevance 0.27 Pain Relevance 0.13

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